Protein Alignment TTLL3B and TTLL8

DIOPT Version :10

• Sequence 1: NP_609068.2
• Gene: TTLL3B / 33946
• FlyBaseID: FBgn0031853
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: XP_024307940.1
• Gene: TTLL8 / 164714
• HGNCID: 34000
• Length: 776
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 205/712 - (28%)
• Similarity: 316/712 - (44%)
• Gaps: 170/712 - (23%)

  Fly   135 AYRNRRIFTVYGNYHTVRRALMRRGWLEK----LPA--------------SRHAKLQSMSEDALL 181
            |.:.::||::||:|..||.||.|:||:||    ||.              ...||::...|.||
Human    51 AIKEKKIFSIYGHYPVVRAALRRKGWVEKKFHFLPKVIPDVEDEGARVNDDTCAKVKENQEMAL- 114

  Fly   182 EHARRGNDYEAVVISKMINHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLD-------FSTKV 239
              .:..|.::  |:|:::.:...:.:|..|  ||:..     .:.:...|.|:       |:||:
Human   115 --EKTDNIHD--VMSRLVKNEMPYLLWTIK--RDIID-----YHSLTYDQMLNHYAKTASFTTKI 168

  Fly   240 GLVGCAEQERWY---REDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVREHQ--- 298
            ||........||   ..|..    :||.|.|...:  |:..|:||:::|.|.|:|.:|..||
Human   169 GLCVNMRSLPWYVPANPDSF----FPRCYSLCTES--EQQEFLEDFRRTMASSILKWVVSHQSCS 227

  Fly   299 ------PAELISENGT------------------IFSTTLDFALGKVKKMVRHAEHYSLDDARIK 339
                  |.:...|.|:                  :....:|.|....:..:...||..:|
Human   228 RSSRSKPRDQREEAGSSDLSSRQDAENAEAKLRGLPGQLVDIACKVCQAYLGQLEHEDID----- 287

  Fly   340 PPTPAEIVEN-----------QTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQIESLRPD 393
              |.|:.||:           |.:.:...|...||::         .|.......|::|.|:.|.
Human   288 --TSADAVEDLTEAEWEDLTQQYYSLVHGDAFISNSR---------NYFSQCQALLNRITSVNPQ 341

  Fly   394 YRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSN----NQNKKYIVQKYIERPLLIYRTKF 454
            ...||.||:||:||..:|||..||....:::||:..:.    :::.|::||||||.||||..|||
Human   342 TDIDGLRNIWIIKPAAKSRGRDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIETPLLICDTKF 406

  Fly   455 DIRQYMLLTITD-TKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSVQKRYKNKTNRDSRLPK 518
            ||||:.|  :|| ..::||.|::.|||||:|.|::|.|..:|||.||:|||..||...|...||.
Human   407 DIRQWFL--VTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCNNAVQKYLKNDVGRSPLLPA 469

  Fly   519 NNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELLQNAFELYGCDFMLDEHY 583
            :|||:..:|:.||:..|......|..|...|:.:...:..:.|..|..:|:|||||.||:|...:
Human   470 HNMWTSTRFQEYLQRQGRGAVWGSVIYPSMKKAIAHAMKVAQDHVEPRKNSFELYGADFVLGRDF 534

  Fly   584 NPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLFELAFE----------- 637
            .|.||||||:|.:.|||.:||::|..|.:|.|:|.||    .:...|.|||.:.
Human   535 RPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVAVD----RSCDIGNFELLWRQPVVEPPPFSG 595

  Fly   638 -----VNYSINKG----------------ADGKPLELNGKQMTLFENMPRMRNSPRTRLLRKILN 681
                 ...|:.:.                .|.:||:..|...     ||.....|.:..|::.|.
Human   596 SDLCVAGVSVRRARRQVLPVCNLKASASLLDAQPLKARGPSA-----MPDPAQGPPSPALQRDLG 655

  Fly   682 NVKTSTTKKVEKVVEAPAKNVKNPTAKITKKKKLSASAGSSTAASAQPSTQNLTTKLILNPA 743
                   .|.||.:         |.|.:...:..:.|.|     :|||:......|:.| ||
Human   656 -------LKEEKGL---------PLALLAPLRGAAESGG-----AAQPTRTKAAGKVEL-PA 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:397308	118/316 (37%)
TTLL8	XP_024307940.1	TTL	<348..574	CDD:397308	100/231 (43%)