DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL3B and Ttll3

DIOPT Version :9

Sequence 1:	NP_609068.2	Gene:	TTLL3B / 33946	FlyBaseID:	FBgn0031853	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_598684.4	Gene:	Ttll3 / 101100	MGIID:	2141418	Length:	927	Species:	Mus musculus

Alignment Length:	818	Identity:	214/818 - (26%)
Similarity:	367/818 - (44%)	Gaps:	183/818 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SSMGSNNFS-------PDSIGNL-------LARVRASTPLP-------------RTVTSSPTAPE 118
            ||:.:.:.|       |.::|.:       |.......|||             |.:|..|.
Mouse    86 SSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPN--- 147

  Fly   119 AQKRQMRNVYRTRVIDAYRNRRIFTVYGNYHTVRRALMRRGWLEK---------LPASR------ 168
             ...::||. :..|..|.:.::||.::|.|..:|..|.:|||:||         |||.:
Mouse   148 -HMGRLRNA-KIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSS 210

  Fly   169 ------------------HAKLQSMSEDALLEHARRGNDYEAV--VISKMINHFPAFFIWQGKGQ 213
                              ..:.|.:..|..||.    :|.:.:  ::|:|:.:...:.||..:
Mouse   211 MLGDSDATEDEDEEENEMFRESQLLDLDGFLEF----DDLDGIHALMSRMVRNETPYLIWTTR-- 269

  Fly   214 RDL--CAEVRPFRNRVRRSQFLD-------FSTKVGLVGCAEQERWYREDGVCGMSYPRFYRLGG 269
            ||:  |       ..:.:.|.::       |:|||||........|: ::......:||.||||.
Mouse   270 RDVLDC-------RFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWF-DEADADSFFPRCYRLGA 326

  Fly   270 NNLEERMAFIEDYQQTQARSLL--------------LYVREH------QPAELISENGTIFSTTL 314
            .  :::.|||||:..|.||::|              :..||.      ||.:...:..|:.|..:
Mouse   327 E--DDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFV 389

  Fly   315 DFALGKVKKMVRHAEHYSLDDARIKPPTPAEIVEN--QTFMVQSTDVLKSNAKFKVSEKVMAEYA 377
            |.||...::.:....|..:|.   .|.:|..:..:  ..|:.:...::...|:.:..|   .:..
Mouse   390 DEALSACQEHLSSIAHKDIDK---DPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLE---VQVQ 448

  Fly   378 RLAGLYLDQIESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNN----QNKKYI 438
            |...: |.|::::.|....:|.||:||:|||.:|||.||:..:.||::|:....|    ::.|:|
Mouse   449 RCEDI-LQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWI 512

  Fly   439 VQKYIERPLLIYRTKFDIRQYMLLTITD-TKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSV 502
            |||||||||||:.||||:||:.|  :|| ..:::|.|||.|:|||:|.|::.:|..|:||.|||:
Mouse   513 VQKYIERPLLIFGTKFDLRQWFL--VTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSI 575

  Fly   503 QKRYKNKTNRDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSKT-YNGFKQNLVAVVMASLDETELL 566
            |:..:...:|...||.:||||..:|:.:|:.:.||. :||.. ..|.|..::..:..|.|..:..
Mouse   576 QRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPK-AWSSVIVPGMKAAVIHALQTSQDNVQCR 639

  Fly   567 QNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGL 631
            :.:|||||.||:..|.:.|.|||||::|.::|||.:|||:|..|..|.:|||:|...:.:..||.
Mouse   640 KASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGA 704

  Fly   632 FELAFE-----------VNYSINKGADGKPLELNGKQMTLFENMPRM-----------RNSPRTR 674
            |||.::           :...:......||:.:..::..:..::|.:           ..||..|
Mouse   705 FELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHR 769

  Fly   675 LLRKILNNVKTSTTKKVEKVVEA-------------------------PAKNVKNPTAKITKKK- 713
            ...:  .|.:..:.:..||...|                         |:..|..|..::.:.:
Mouse   770 SASR--KNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQH 832

  Fly   714 -KLSASAGSSTAASAQPSTQNLTTKLILNPATRENLAL 750
             :|..|...||...|..:..  |.|::::.....:|.|
Mouse   833 DQLVGSKALSTTGKALMTLP--TAKVLMSFPPHPDLKL 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:281171	113/308 (37%)
Ttll3	NP_598684.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..113		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..227		3/32 (9%)
		TTL	423..698	CDD:281171	109/281 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..799		8/65 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..927
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10747
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000675
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45870
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.870