DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL3B and ARPC4-TTLL3

DIOPT Version :9

Sequence 1:	NP_609068.2	Gene:	TTLL3B / 33946	FlyBaseID:	FBgn0031853	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001185722.1	Gene:	ARPC4-TTLL3 / 100526693	HGNCID:	38830	Length:	625	Species:	Homo sapiens

Alignment Length:	554	Identity:	174/554 - (31%)
Similarity:	268/554 - (48%)	Gaps:	116/554 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 RRIFTVYGNYHTVRRALMRRGWLEK----------LPASRHAKLQSMSEDALLEHARRGNDYEAV 193
            ::|||:.|.|..:|..|.||||:||          ||..:.....:|.:....|......|
Human   112 KKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDED---- 172

  Fly   194 VISKMINHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLDF----------STKVGLVGCAEQE 248
                                    .|.:|       ||..||          .|...:||.....
Human   173 ------------------------EEFQP-------SQLFDFDDLLKFDDLDGTHALMVGLCLNL 206

  Fly   249 R---WYREDGVCGMS-YPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVREHQPAELISENGTI 309
            |   |:  |.|...| :||.|.||..  :::.|||.|.|..:        :|..|. |:|..
Human   207 RNLPWF--DEVDANSFFPRCYCLGAE--DDKKAFIGDKQPKK--------QEKNPV-LVSPE--- 255

  Fly   310 FSTTLDFALGKVKKMVRHAEHYSLDDARIKPP---TPAEIVENQTFMVQSTDVLKSNAKFKVSEK 371
               .:|.||...::.:.:..|..: |..::.|   ||    |..:..:|.            ..:
Human   256 ---FVDEALCACEEYLSNLAHMDI-DKDLEAPLYLTP----EGWSLFLQR------------YYQ 300

  Fly   372 VMAEYARLAGL---------YLDQIESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQ 427
            |:.|.|.|..|         .|.|::::.|....:|.||:||:|||.:|||.||:....|:::|:
Human   301 VVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLEEMLK 365

  Fly   428 WTSNN----QNKKYIVQKYIERPLLIYRTKFDIRQYMLLTITD-TKVSIWTYRDCYLRFSSQEFT 487
            ..:.|    ::.|::|||||||||||:.||||:||:.|  :|| ..:::|.|||.|:|||:|.|:
Human   366 LVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFL--VTDWNPLTVWFYRDSYIRFSTQPFS 428

  Fly   488 MDDLRESIHLTNNSVQKRYKNKTNRDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSK-TYNGFKQN 551
            :.:|..|:||.|||:||..:|..:|...||.:||||..:|:.:|:.||||: :||. ...|.|..
Human   429 LKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPN-AWSTIIVPGMKDA 492

  Fly   552 LVAVVMASLDETELLQNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIR 616
            ::..:..|.|..:..:.:|||||.||:..|.:.|.|||||::|.::|||.:|||:|..|..|.:|
Human   493 VIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLR 557

  Fly   617 VVVDLPKNPTAATGLFELAFEVNYSINKGADGKP 650
            ||:|...:....||.|||.::...:.:..:..:|
Human   558 VVIDRMLDRNCDTGAFELIYKQPVTTSPASTPRP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:281171	119/318 (37%)
ARPC4-TTLL3	NP_001185722.1	ARPC4	1..>110	CDD:283507
ARPC4-TTLL3	NP_001185722.1	TTL	274..566	CDD:281171	118/311 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.860