DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL3B and XB5950141

DIOPT Version :9

Sequence 1:	NP_609068.2	Gene:	TTLL3B / 33946	FlyBaseID:	FBgn0031853	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	XP_012816101.1	Gene:	XB5950141 / 100158544	XenbaseID:	XB-GENE-5950142	Length:	901	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	218/794 - (27%)
Similarity:	351/794 - (44%)	Gaps:	179/794 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SNNFSPDSIGNLLARVRASTPLPRTVTSSPTAPEAQKRQMRNVYR-------------------- 129
            :.|..|||  |....:|            ||| |.||..:....|
Frog    33 AQNTPPDS--NSKKNIR------------PTA-EKQKHDVSTTERHARKMAHHTAVNPDRLKHAK 82

  Fly   130 TRVIDAYRNRRIFTVYGNYHTVRRALMRRGWLE-KLPASRHA--KLQSMSEDALLEHARRGN--- 188
            ..|..|.:.::||.::|.|..:|..|..|||:| |.|.|..|  |.:..|::.:.:....|:
Frog    83 ALVEKAIKQKKIFAIHGPYPVIRSCLRSRGWVEKKFPKSGKAKQKKEKASDEDMEDDDGDGSSND 147

  Fly   189 ---------------DYEAVVISKMI-NHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLD--- 234
                           |....::|::: |..|.|| |..|.....|       ..:::.|.|:
Frog   148 DDDGENSDEEENGDPDGTCDLMSRLLRNEDPNFF-WTTKRDAVDC-------RFLKKDQMLNHYA 204

  Fly   235 ----FSTKVGLVGCAEQERWYREDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVR 295
                |:|||||........|: :|......:||.||||..  :|:.:|.||:..|.|||:|..|.
Frog   205 KAGSFTTKVGLCLNLRNLHWF-DDADPDSFFPRCYRLGAE--DEKQSFKEDFWHTAARSILKRVA 266

  Fly   296 EHQ----PA----------ELISENGTIFSTTLD----------------------FALGKVKKM 324
            ..:    ||          |..:.||   :..||                      .||...::.
Frog   267 NRRDICSPAATGGAKASHREPGANNG---AQLLDSSPVAKRGSRKRAESVPVQIILTALEACERY 328

  Fly   325 VRHAEHYSLDDARIKPPTPAEIVENQTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQIES 389
            :...||..:|......|...: .:.:.|:.....|:...|..:.||..:.:.:.:    |.::|:
Frog   329 LNSLEHNDIDMETEATPAMTD-TQWEEFLHGYYQVIHDGATIEHSEYYVDQCSEV----LHKLEA 388

  Fly   390 LRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNN----QNKKYIVQKYIERPLLIY 450
            :.|....:|.||:||:|||.:|||.||:....|::||:....:    ::.|::|||||||||||:
Frog   389 VNPQLDIEGGRNIWIVKPGAKSRGRGIICMDRLEEILKLVDCDPMIVKDGKWVVQKYIERPLLIF 453

  Fly   451 RTKFDIRQYMLLTITD-TKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSVQKRYKNKTNRDS 514
            .||||:||:.|  :|| ..::||.|::||:|||||.|::::|..||||.|||:||.|:|..:|..
Frog   454 GTKFDVRQWFL--VTDWNPLTIWFYKECYVRFSSQPFSLENLDTSIHLCNNSIQKHYENSQSRHP 516

  Fly   515 RLPKNNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELLQNAFELYGCDFML 579
            .:|.:||||..|.:.:|..:|||....:....|.|..::..:.::.|..|..:::|||||.|||.
Frog   517 LVPTDNMWSSRQLQVHLHKLGAPHAWEAVIVPGMKAAIIHAMQSAQDIVEYRKSSFELYGADFMF 581

  Fly   580 DEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLFELAFE------- 637
            .|:::|.|||||::|.::.||.:|:|:|..|.:|.:|:|:|...:.....|.|||.::
Frog   582 GENFHPWLIEINASPTMAASTTVTSRLCAEVQEDTLRIVLDRKLDRNCDIGAFELIYKQCAVDIP 646

  Fly   638 ----VNYSINKGADGKPLEL-----NG----------KQMTLFENMPRMRNSP------------ 671
                :|..:......||.:|     ||          |:.....|.....::|
Frog   647 QYLGINLLVEGSMVKKPRQLQQPNPNGAFNFSIVQSNKRSVSLLNAKTSGSNPGVGSQDSVKVAV 711

  Fly   672 RTRLLRKILNN-------------VKTSTTKKVEKVVEAPAKN-VKNPTAKITKKKKLSAS-AGS 721
            .||....::.|             .||:...|..|..|...:| |.....::..|:.|..| .|:
Frog   712 PTRTAPAVMGNDFWTSRTHGTIGRAKTTAAGKENKAAEGGQRNSVMVELVRLPSKRALEQSKEGT 776

  Fly   722 STAASAQPSTQNLT 735
            :......|:.::.|
Frog   777 NPRQRLFPAPKSCT 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:281171	113/305 (37%)
XB5950141	XP_012816101.1	TTL	359..620	CDD:281171	106/266 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000675
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45870
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010