DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment homer and HOMER1

DIOPT Version :9

Sequence 1:	NP_001036341.2	Gene:	homer / 33944	FlyBaseID:	FBgn0025777	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_004263.1	Gene:	HOMER1 / 9456	HGNCID:	17512	Length:	354	Species:	Homo sapiens

Alignment Length:	416	Identity:	158/416 - (37%)
Similarity:	220/416 - (52%)	Gaps:	90/416 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGEQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNM 65
            |||||||:.:||||.|||.||:.|:..|..||.||:||||:||:|||||::|:||:|||||||||
Human     1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNM 65

  Fly    66 TFTQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSAN 130
            |||:||||||||:|.||||||||||:||..|:||.|||||.|||.:.|.:.:.....:|.|.|..
Human    66 TFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQE 130

  Fly   131 TSPISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQP 195
            :      |.|.:|:..|        |.:::.|:.:            .|.||..   ::.|..:|
Human   131 S------AGGDLQSPLT--------PESINGTDDE------------RTPDVTQ---NSEPRAEP 166

  Fly   196 TSGVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCANAKKWEIELATLKN 260
            |...                                       :..:.|.|.:|.||.||||||.
Human   167 TQNA---------------------------------------LPFSHSSAISKHWEAELATLKG 192

  Fly   261 NNIRLTSALQESTANVDEWKRQLHTYKEENIRL-KRDMEQLCVGGGVVAAAGGGATEDELRREV- 323
            ||.:||:||.||||||.:||:||..|:||..|| ||..|..||.....|.   ...:.||.:.:
Human   193 NNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAV---HTHKTELNQTIQ 254

  Fly   324 ---ATLKARTEQLQKELMQQEL----ELKSANISLREK------SNDQTLAKLSEVNGVFAKHLS 375
               .|||.:.|::::  ::||:    ||:....||.:|      .|.....:||::.....|..:
Human   255 ELEETLKLKEEEIER--LKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQN 317

  Fly   376 ELYGVQKDMESLIQI--AKCTXDTEL 399
            |....:.::::|::|  .|....|||
Human   318 EQEAFRNNLKTLLEILDGKIFELTEL 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	78/107 (73%)
HOMER1	NP_004263.1	EVH1_Homer_Vesl	3..111	CDD:269917	78/107 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..173		15/126 (12%)
		SMC_N	<157..>352	CDD:330553	65/234 (28%)
		Required for tetramerization. /evidence=ECO:0000250\|UniProtKB:Q9Z214	290..354		12/54 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3963
eggNOG	1	0.900	-	-		E1_28ISB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3280
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251658at2759
OrthoFinder	1	1.000	-	-		FOG0004784
OrthoInspector	1	1.000	-	-		otm42043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7014
SonicParanoid	1	1.000	-	-		X1808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960