Protein Alignment homer and HOMER2

DIOPT Version :9

• Sequence 1: NP_001036341.2
• Gene: homer / 33944
• FlyBaseID: FBgn0025777
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_006720838.1
• Gene: HOMER2 / 9455
• HGNCID: 17513
• Length: 364
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 166/393 - (42%)
• Similarity: 213/393 - (54%)
• Gaps: 102/393 - (25%)

  Fly     3 EQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNMTF 67
            ||||||.:||||.|||.||:.|:.||.:||.||:|||.:||.||||||:|.|.:|||||||||||
Human    13 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTF 77

  Fly    68 TQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSANTS 132
            |:||||||||:|.|||||:||||:||.:||||.|||||||||.    |.|.........||:|.|
Human    78 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAA----KIAKDKTQEKIETSSNHS 138

  Fly   133 PISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQPTS 197
            ..|||                 |.|  |:|...:.|         .|.|.||.
Human   139 QESGR-----------------ETP--SSTQASSVN---------GTDDEKAS------------ 163

  Fly   198 GVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCANAKKWEIELATLKNNN 262
                               |.||     |...||.||::||:||.||.||.|||||||.||:.:|
Human   164 -------------------HAGP-----ANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESN 204

  Fly   263 IRLTSALQESTANVDEWKRQLHTYKEENIRLKR---DMEQLCVGGGVVAAAGGGATEDELRREV- 323
            .|||:|||||.|:|::||||....::||.||:.   ::|:.|               .|:.||.
Human   205 ARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQC---------------SEINREKE 254

  Fly   324 --ATLKARTEQLQKELMQQELELKSANISLREKSN--DQTLAKLSEVNGVFAKHLSELYGVQKDM 384
              ..||.|.|:|:.||.::|.|||    .||::|.  .|.:::...|:       .:|...::|.
Human   255 KNTQLKRRIEELEAELREKETELK----DLRKQSEIIPQLMSECEYVS-------EKLEAAERDN 308

  Fly   385 ESL 387
            ::|
Human   309 QNL 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	80/107 (75%)
HOMER2	XP_006720838.1	EVH1_Homer_Vesl	13..121	CDD:269917	80/111 (72%)
		SMC_N	<103..343	CDD:330553	100/303 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160349
Domainoid	1	1.000	163	1.000	Domainoid score	I3963
eggNOG	1	0.900	-	-		E1_28ISB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3560
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3280
Isobase	1	0.950	-	0	Normalized mean entropy	S3324
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251658at2759
OrthoFinder	1	1.000	-	-		FOG0004784
OrthoInspector	1	1.000	-	-		otm42043
orthoMCL	1	0.900	-	-		OOG6_106337
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7014
SonicParanoid	1	1.000	-	-		X1808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.640