Protein Alignment homer and HOMER3

DIOPT Version :9

• Sequence 1: NP_001036341.2
• Gene: homer / 33944
• FlyBaseID: FBgn0025777
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001139194.1
• Gene: HOMER3 / 9454
• HGNCID: 17514
• Length: 361
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 152/425 - (35%)
• Similarity: 212/425 - (49%)
• Gaps: 107/425 - (25%)

  Fly     3 EQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNMTF 67
            |||||:.:||||.|||.|||.||.|...|:.||:|||::||:|||||:.|.||:||||:||||||
Human     6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTF 70

  Fly    68 TQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAM-KSANGSNAVTPTTSANT 131
            |:||||||||:|.|||||||||||||..||:|.|||||||||.:.|. ||.:|...        |
Human    71 TKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGEL--------T 127

  Fly   132 SPISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQPT 196
            ||..|.|            .|.|.|..:.:.|       .|..:.|..|. .||      :|.||
Human   128 SPALGLA------------SHQVPPSPLVSAN-------GPGEEKLFRSQ-SAD------APGPT 166

  Fly   197 SGVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCANAKKWEIELATLKNN 261
                                                |.||||..|::......:||.|...|:::
Human   167 ------------------------------------ERERLKKMLSEGSVGEVQWEAEFFALQDS 195

  Fly   262 NIRLTSALQESTANVDEWKRQLHTYKEENIRLKRDMEQL-------CVGGGVVAAAGGGATEDEL 319
            |.:|..||:|:.|...:|::||...:.|..||::.:.:|       ....|.....|.|.:.::|
Human   196 NNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQL 260

  Fly   320 R-------REVATLKART-------EQLQKELMQ---QELELKSANI---------SLREKSNDQ 358
            .       :|:.|||::|       |..::|..|   |:||.::|.:         ||.|...::
Human   261 EALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAER 325

  Fly   359 TLAKLSEVNGVFAKHLS-ELYGVQKDMESLIQIAK 392
            ..|: :|| |..|:.|. .|:.:.:..|.|.::|:
Human   326 ERAR-AEV-GRAAQLLDVSLFELSELREGLARLAE 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	79/107 (74%)
HOMER3	NP_001139194.1	Required for interaction with NFATC2. /evidence=ECO:0000269|PubMed:18218901	1..80		51/73 (70%)
		EVH1_Homer_Vesl	6..114	CDD:269917	79/107 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..169		22/124 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3963
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3280
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251658at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.030