DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment homer and homer3

DIOPT Version :9

Sequence 1:	NP_001036341.2	Gene:	homer / 33944	FlyBaseID:	FBgn0025777	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001164991.1	Gene:	homer3 / 779484	XenbaseID:	XB-GENE-962123	Length:	357	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	151/436 - (34%)
Similarity:	209/436 - (47%)	Gaps:	139/436 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNMTF 67
            |||||:.:||||.|||.||:.|:.||..||.||:|||::||:||||||.||||:|||||||||||
Frog     8 EQPIFSTRAHVFQIDPITKKNWLPASKHAVTVSYFYDATRNVYRIISVGGTKAIINSTITPNMTF 72

  Fly    68 TQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSANTS 132
            |:||||||||:|.|||||||||||||..|::|.||||||:||.:.|.:.:.....:|
Frog    73 TKTSQKFGQWADSRANTVYGLGFASEQNLSQFAEKFQEVREAARLARERSQDKTDLT-------- 129

  Fly   133 PISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQPTS 197
                                   .|.::.|:.|                       ..|||
Frog   130 -----------------------NPALNITSQQ-----------------------VLPSP---- 144

  Fly   198 GVTGGGGVTISSGGSIVGMHTGPG-----AGATAEQQLKYENERLKMALAQSCANAKKWEIELAT 257
                    .||:        .|||     ...:||.:|..|.||:|..|::......:||.|..:
Frog   145 --------IISA--------NGPGDDKLFRSQSAEMELSTERERVKKMLSEGSVCEVQWEAEFFS 193

  Fly   258 LKNNNIRLTSALQESTANVDEWKRQLHTYKEE---------------------------NIRLKR 295
            |::||.:|.:||:||.|||::||:||..|:||                           .:|||
Frog   194 LQDNNNKLVAALRESNANVEKWKKQLAAYQEEAETLRQRVAELESQTLKETNEEPGDELALRLK- 257

  Fly   296 DMEQLCVGGGVVAAAGGGATED--------------ELRREVATLKARTEQLQKELMQQELELKS 346
            |:|.|.            .|::              ||..|...|..|.::|::...:.|.||:.
Frog   258 DLETLL------------KTKEEEILLLKEQRPDLMELESERDKLLQRLQELEERNQEMEKELER 310

  Fly   347 ANISLREKSND-----QTLAKLSEVNGVFAKHLSEL-YGVQKDMES 386
            :..|||:..::     :.::|..|...|....|:|| .|:.|.:||
Frog   311 SEQSLRDSQSERDRVREEISKAGEDLDVKICQLNELRIGLSKLLES 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	80/107 (75%)
homer3	NP_001164991.1	EVH1_Homer_Vesl	8..116	CDD:269917	80/107 (75%)
homer3	NP_001164991.1	SMC_N	<153..>347	CDD:330553	53/206 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3348
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251658at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49273
Panther	1	1.100	-	-	LDO	PTHR10918
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160