DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment homer and Homer3

DIOPT Version :9

Sequence 1:	NP_001036341.2	Gene:	homer / 33944	FlyBaseID:	FBgn0025777	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_036009953.1	Gene:	Homer3 / 26558	MGIID:	1347359	Length:	368	Species:	Mus musculus

Alignment Length:	334	Identity:	105/334 - (31%)
Similarity:	153/334 - (45%)	Gaps:	93/334 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TKAVINSTITPNMTFTQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAM-KS 116
            ::|:||||:|||||||:||||||||:|.|||||||||||||.:||:|.|||||||||.:.|. ||
Mouse    58 SQAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQQLTQFAEKFQEVKEAARLAREKS 122

  Fly   117 ANGSNAVTPTTSANTSPISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSD 181
            .:|                    |...:...|:..|.|.|..:.:||       .|..:.|..|.
Mouse   123 QDG--------------------GEFTSTGLALASHQVPPSPLVSTN-------GPGEEKLFRSQ 160

  Fly   182 VKADIGSATPSPQPTSGVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCA 246
             .||      :|.||                                    |.||||..|::...
Mouse   161 -SAD------TPGPT------------------------------------ERERLKKMLSEGSV 182

  Fly   247 NAKKWEIELATLKNNNIRLTSALQESTANVDEWKRQLHTYKEENIRLKRDMEQL-------CVGG 304
            ...:||.|...|:::|.||..||:|:.|...:|::||...:.|...|::.:.:|       .|..
Mouse   183 GEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLEVQRAEAELLRQRVAELEAQVAVEPVRA 247

  Fly   305 GVVAAAGGGATEDELR-----REVATLKART-------EQLQKELMQQELEL---KSANISLREK 354
            |...|......:.|.|     :|:.|||.::       :..::|..||::::   .||::..|..
Mouse   248 GEKEATSQSVEQLEARVQTKDQEIQTLKNQSTGTREAPDTAEREETQQQVQVGCRTSADLETRNA 312

  Fly   355 SNDQTLAKL 363
            ..:|.|..:
Mouse   313 ELEQQLRSM 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	46/57 (81%)
Homer3	XP_036009953.1	PH-like	<58..116	CDD:418428	46/57 (81%)
Homer3	XP_036009953.1	Smc	<153..>349	CDD:224117	47/212 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1251658at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44098
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.030