DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment homer and SPBC800.10c

DIOPT Version :9

Sequence 1:	NP_001036341.2	Gene:	homer / 33944	FlyBaseID:	FBgn0025777	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_595112.1	Gene:	SPBC800.10c / 2540824	PomBaseID:	SPBC800.10c	Length:	1116	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	133/583 - (22%)
Similarity:	214/583 - (36%)	Gaps:	181/583 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 W--SDVRANTVYGLG-FASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSANTS-PISGR 137
            |  ||..:|....:| |.....|.|.....:|:.:...::|.|     :|.|....:.| |
pombe   301 WDLSDTNSNGKLNIGEFCISLYLIKLKLSGKELPKVLPSSMLS-----SVAPLMQKSKSVP---- 356

  Fly   138 AVGSMQNDNTAIDPHTVEPPNMSNTN---TQNANPDSPSHKLLNTSD---VKADIGSATPSPQPT 196
                     |:|.  :|.|.|:|:.|   |...||..||.....|.|   :.|...|.|.:||.|
pombe   357 ---------TSIP--SVVPANISSPNPNPTLAPNPTGPSRVTSGTEDLLSLDATPFSPTLAPQHT 410

  Fly   197 SGVT---GGGGVTISSGGSIV---------GMHTGPGA---------------GAT--------- 225
            |...   ....||.|:...:|         |..|.|.|               |.|
pombe   411 SSNATKHSAPPVTKSAPFPVVSPLQLNHTPGFPTSPAAKPNSPTSTFFPQSSFGQTIAKNTMDKP 475

  Fly   226 ------AEQQLK------YENERLKMALAQSCANAKKWEIELATLKNNNIRLTSALQESTANVDE 278
                  ...||.      ...|:||:|     |...|.|.:|:.:|.:|..|..:.::..||:.:
pombe   476 SAVRTSVPSQLAAPIPQVASAEQLKLA-----AEVPKLESQLSQVKKSNDDLQKSSRDVAANLSD 535

  Fly   279 WKRQL----HTYKEENIRLKR---DMEQLCVGGGVVAAAGGGATEDELRREVATLKARTEQLQK- 335
            .|.::    ..|.||..:.|:   |:|.            ..|..:::.||.:.|:|....|||
pombe   536 VKAKVSEIRKAYDEELAKAKQISLDIET------------NKAQTEQVNREYSILEATLNALQKQ 588

  Fly   336 -----ELMQQ---ELE-----LKSANISLRE-KS----NDQTLAKL---------------SEVN 367
                 |:::|   |.|     ::|:|.|::: ||    .:||||:|               .|..
pombe   589 NKQKGEVLEQVVAESEAAKNMVESSNASIQQLKSEVADKEQTLAQLHLQLDEMTQRLVSLDEESK 653

  Fly   368 GVFAKHLSELYGVQKDMESLIQIAKCTXD------------TELA----FMRKVSVQEQTTMINT 416
            .|..:.|...|.:.   .|..|:|..| :            .||:    .::.|::.|:......
pombe   654 AVSQRKLDLEYKIN---NSKTQLATATEEYHEHSKQLEAEKQELSKLEDGLKSVNLTEEAPKPEV 715

  Fly   417 TTT----SSTTTGSTTSKRYLSNFPTAEAESTLSNVTSIHTQLQSSLYETQNMPQLKALDK--HS 475
            .:|    |.|:.|.||.|      ||  ...|.|:|.:.|... .:::.|...|.|.:.:.  |:
pombe   716 DSTPRFPSFTSNGITTDK------PT--LPDTTSSVPTQHNSF-DAMHNTLRSPSLNSNNSSAHA 771

  Fly   476 ALLQE--LHQRQ----AAPRRNSASAEAAAA--GSGGAKTATILVSKSKTKTGL---PLLLKN 527
            :.:..  .|..:    ::|..|...:|.|:|  ....:||.::.|:.|.....|   |:.|.|
pombe   772 STVSRNPFHNLKISGASSPVSNFWESEFASAVFPRSISKTTSLSVNNSSVNPSLDSEPVQLSN 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	9/36 (25%)
SPBC800.10c	NP_595112.1	EH	13..79	CDD:238009
		EH	138..203	CDD:238009
		EH	252..345	CDD:197477	11/48 (23%)
		EH	263..329	CDD:238009	8/27 (30%)
		KASH_CCD	493..701	CDD:291334	52/227 (23%)
		BAR	499..704	CDD:299863	51/224 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000