DRSC/TRiP Functional Genomics Resources

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Protein Alignment Aatf and AATF

DIOPT Version :9

Sequence 1:NP_609066.1 Gene:Aatf / 33943 FlyBaseID:FBgn0031851 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_036270.1 Gene:AATF / 26574 HGNCID:19235 Length:560 Species:Homo sapiens


Alignment Length:571 Identity:183/571 - (32%)
Similarity:277/571 - (48%) Gaps:118/571 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVD-FEEEEYDLPDARSTDF------RKRNVK 66
            ||.:|.::.:|| :|..|::..::|.:.||..|::| |:|.|    |... ||      ||....
Human     4 PQPLALQLEQLL-NPRPSEADPEADPEEATAARVIDRFDEGE----DGEG-DFLVVGSIRKLASA 62

  Fly    67 LLSEQSDRYKGKISSRKELDDDE-----DKDDEQEVSYEE--SDEDDENLTNFKQKLNAGGAEDS 124
            .|.:...||.||.:|||..::|.     ....::|:|.||  .|||.|.|          |.|:.
Human    63 SLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGL----------GLEEY 117

  Fly   125 EEET--AAGHSESGEESEEIES-------------NLTDFKKKFEAGDFKYDDDEEEDDDS--EE 172
            :|:.  ||...|.|:..|..:|             :::||:|..:..|.....:||||::|  ||
Human   118 DEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEE 182

  Fly   173 EDHSQESEG--DDDDSEDDEAEDDAIKPSDVM--SKTNHQAEIQKGLAVQNQLRIWERLLELRIN 233
            .|.:::|:|  ::|.:.|..:|||.:    ||  |......|::||.||:||:.:|::|||.||.
Human   183 GDDAEDSQGESEEDRAGDRNSEDDGV----VMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIK 243

  Fly   234 TQKFTSKANQLPAPETLTKLASE-SDELQSVLNEAQERSSKLLQQLLSLQSALHQQY-------- 289
            .||.....||||.|:.......: ..|..|.|..:.:....||:.|:.||..|..||        
Human   244 LQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVD 308

  Fly   290 ------------SEMKKSVKRKQPTEDSGPAVKK-----FGSVLQSNFQQMIGYRNEVLLKWDDR 337
                        ||..:.|:.|:......||.:|     :.|.:...|.....|||..|.||.|:
Human   309 GTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDK 373

  Fly   338 TKL----LTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQT----------PKNSQAEQQE 388
            |||    |..|.|...:|      |:.:|...|.::|.|:.::||          |:.:.....|
Human   374 TKLASGKLGKGFGAFERS------ILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPE 432

  Fly   389 NTPVQ-----------RLK----HIYDDSDFYHQQLRELIEYKASTSSNMSEIT--KQFVELQKL 436
            :.|.:           .||    .|:||.|||||.||||||.|.|:.....::.  :|::.:|||
Human   433 SLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKL 497

  Fly   437 RQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLF 487
            |.|:.||||.:||||||||:.|.:||::||||.:.:...|.:::|||:|||
Human   498 RSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLF 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AatfNP_609066.1 AATF-Che1 211..337 CDD:290078 45/151 (30%)
TRAUB 405..487 CDD:285388 41/83 (49%)
AATFNP_036270.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..208 41/141 (29%)
AATF-Che1 221..373 CDD:290078 45/151 (30%)
POLR2J binding 273..315 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..333 4/23 (17%)
RB1 binding 316..372 15/55 (27%)
RB1 and SP1 binding 373..472 30/104 (29%)
TRAUB 464..548 CDD:285388 41/83 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 84 1.000 Domainoid score I8303
eggNOG 1 0.900 - - E1_KOG2773
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 211 1.000 Inparanoid score I3664
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54578
OrthoDB 1 1.010 - - D428754at33208
OrthoFinder 1 1.000 - - FOG0005185
OrthoInspector 1 1.000 - - oto89119
orthoMCL 1 0.900 - - OOG6_102684
Panther 1 1.100 - - LDO PTHR15565
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R139
SonicParanoid 1 1.000 - - X4800
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.910

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