DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AkhR and Gnrhr

DIOPT Version :9

Sequence 1:	NP_995639.1	Gene:	AkhR / 33942	FlyBaseID:	FBgn0025595	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_112300.2	Gene:	Gnrhr / 81668	RGDID:	70513	Length:	327	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	104/338 - (30%)
Similarity:	186/338 - (55%)	Gaps:	30/338 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AKVAEENDHRDLSNWSNVNDTNGTIHLTKDMV--FNDGHRLSITVYSILFVISTIGNSTVLYLL- 63
            |.:.::.:|        .:..|.:|.||:..:  .....::.:||...||::||..|::.|..|
  Rat     5 ASLEQDQNH--------CSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQ 61

  Fly    64 --TKRRLRGP--LRIDIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLY 124
              |::|.:|.  .|:.::|.||.:|:|:.||::||::.:|..||||.:.:.:|:::|:.::|.:|
  Rat    62 RWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMY 126

  Fly   125 LSSYVMVCISLDRYFAILKPL--KRSYNRGRIMLACAWLGSVVCSIPQAFLFHL-----EEHPAV 182
            ..:::||.|||||..|:.:||  :......|.|.:.||:.|:|.:.||.::|.:     ...|||
  Rat   127 APAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAV 191

  Fly   183 TGYFQCVIFNSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAIYLEIYRKSQRVL-KDVIAERF 246
              :.|||...||...:.|..|...:...::..||::.:.|...|...:    .||| :|....:.
  Rat   192 --FSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFAL----TRVLHQDPRKLQL 250

  Fly   247 RRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWLDKHSAGKINPLLRKALFIFASTN 311
            .:|.::: .||:.||||||:.....|:|||||||.:.:|||.|.....:::..:....|:||..|
  Rat   251 NQSKNNI-PRARLRTLKMTVAFATSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLN 314

  Fly   312 SCMNPLVYGLYNI 324
            .|.:||:||.:::
  Rat   315 PCFDPLIYGYFSL 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AkhR	NP_995639.1	7tm_1	55..319	CDD:278431	90/276 (33%)
Gnrhr	NP_112300.2	7tm_1	76..322	CDD:278431	83/252 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347655
Domainoid	1	1.000	164	1.000	Domainoid score	I3854
eggNOG	1	0.900	-	-		E33208_3BFSB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3901
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	1	1.000	-	-		FOG0003145
OrthoInspector	1	1.000	-	-		oto96236
orthoMCL	1	0.900	-	-		OOG6_105158
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760