DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AkhR and gnrr-2

DIOPT Version :9

Sequence 1:	NP_995639.1	Gene:	AkhR / 33942	FlyBaseID:	FBgn0025595	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001256583.1	Gene:	gnrr-2 / 182647	WormBaseID:	WBGene00007614	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	96/380 - (25%)
Similarity:	165/380 - (43%)	Gaps:	95/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DLSNWSNVNDTNGTIHLTKDMVFNDGHRLSITVYSILFVIS-TIGNSTVLYLLTKRRLRGPLRID 75
            ::||    .:|.|  |:..|..       .:.:|.|..:|. .:..||::|:|.:.|   ..:..
Worm    18 EISN----QETLG--HVPSDYA-------QMLLYGIFALIGLPVNISTLIYMLKRYR---HAKSF 66

  Fly    76 IMLMH--LAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRY 138
            ::|:|  |.|:|::|..|.:|..|.|..|::|.....:|:.|.|...|...:||.:||||:|.|.
Worm    67 LLLLHINLNISDILVLGLYVPGLIGWLVTLEWRGGAYLCKFMRFVDAFVFAISSNIMVCIALYRL 131

  Fly   139 FAILKPL-KRSYNRGRI--MLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCV-----IFNSFR 195
            .|:..|| ..:....|:  ||..||..:||..:||..:::..:...:|   |||     |.|. |
Worm   132 SALRYPLWVNAVGHSRVPRMLILAWALAVVTMLPQMLVWNEVQFSNIT---QCVTVWTEIINK-R 192

  Fly   196 SDFDE------KLYQAASMCSMYAFPLIMFIYCYGAIYLEIYR--------KSQRVLKDVIA--- 243
            ....|      |||...:...::..||::.:.||..|..:||:        .|...|.::.:
Worm   193 EKLSESELRNMKLYSIQNATIIFYIPLMILVACYVLILKDIYKTLNTDTECSSAAYLSEMSSSKT 257

  Fly   244 -------------------------ERFRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTIS 283
                                     |:||        |||.|:|::|:.:::.:.:.|.||..:|
Worm   258 GGKAALHKKDQESFVTLTTRTVRGQEKFR--------RAKVRSLRITLLLILTYAVTWLPYNLLS 314

  Fly   284 MW---YWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYG-------LYNIRGRM 328
            .|   :| |.:.....:..:..:|.:.   ||.:||.:||       |:..|.|:
Worm   315 WWMVLHW-DSYRENLDSNYILNSLVVL---NSVINPFIYGRCQGIRFLFKCRERL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AkhR	NP_995639.1	7tm_1	55..319	CDD:278431	82/318 (26%)
gnrr-2	NP_001256583.1	7tm_GPCRs	38..352	CDD:391938	87/332 (26%)
		TM helix 1	38..59	CDD:341315	7/20 (35%)
		TM helix 2	67..94	CDD:341315	10/26 (38%)
		TM helix 3	105..135	CDD:341315	13/29 (45%)
		TM helix 4	147..168	CDD:341315	9/20 (45%)
		TM helix 5	193..232	CDD:341315	9/38 (24%)
		TM helix 6	287..316	CDD:341315	10/28 (36%)
		TM helix 7	328..352	CDD:341315	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28850
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930