Protein Alignment AkhR and gnrhr2

DIOPT Version :10

• Sequence 1: NP_995639.1
• Gene: AkhR / 33942
• FlyBaseID: FBgn0025595
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001138451.1
• Gene: gnrhr2 / 100270671
• ZFINID: ZDB-GENE-090128-3
• Length: 412
• Species: Danio rerio
• Alignment Length: 375
• Identity: 131/375 - (34%)
• Similarity: 205/375 - (54%)
• Gaps: 30/375 - (8%)

  Fly    17 SNV-NDTNGTIHLTKDMVFNDGHRLSITVYSILFVISTIGNSTVLYLL-TKRRLRGPLRIDIMLM 79
            ||: .|....:||.:   |....::.:|:..:|..:|...|..|||.. ..:|.|..:|  :::.
Zfish    25 SNIAGDLPHPLHLPR---FTAASQVRVTLTLVLCALSACCNLAVLYSANNNQRKRSHVR--LIIT 84

  Fly    80 HLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAILKP 144
            :||.|||:||.::||.:.||..|:||.:.||.||.:.|.::..:|..::|.|.|||||..|||.|
Zfish    85 NLAAADLLVTFVVMPTDAVWNITLQWRAGDLACRTLMFLKLVAMYSCAFVTVVISLDRQAAILNP 149

  Fly   145 L--KRSYNRGRIMLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDFDEKLYQAAS 207
            |  .::..|.:::|..||..|||.||||.|:||:.|..:...:.||..:.||.|.:.|..|...:
Zfish   150 LSINKAMRRNKVLLGVAWTMSVVLSIPQVFVFHVVEIDSPKQFVQCTTYGSFSSRWQETFYNMFT 214

  Fly   208 MCSMYAFPLIMFIYCYGAIYLEIYRK--SQRVLKDVIAERFRRSNDDVLSRAKKRTLKMTITIVI 270
            ...::..||.:.|.||..|..||.:|  ..|:|.:.:  :.|||.::: .:|:.||||||:.||:
Zfish   215 FTFLFLLPLFIMISCYTRILFEISKKMTEDRLLSNKV--QLRRSKNNI-PKARMRTLKMTVVIVL 276

  Fly   271 VFIICWTPYYTISMWYWLDKHSAG---KINPLLRKALFIFASTNSCMNPLVYGLYNI---RGRMN 329
            .|::||||||.:.:|||..  .||   .::..|...||||...|:|::|::|||:.:   || |.
Zfish   277 SFMVCWTPYYMLGLWYWFS--PAGLEETVSQSLSHILFIFGLLNACLDPIIYGLFTVPLCRG-MR 338

  Fly   330 NNNPSVNNRHTSLSNRLDSSNQLMQKQLTNNSLLNGRGQVMAAAVSATTK 379
            :.....|.....|.|   ::|.||....|:.|.|.    :...||..|::
Zfish   339 HRQREQNIVAFELEN---TNNSLMTSIRTSTSPLT----LKRLAVQQTSR 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AkhR	NP_995639.1	7tmA_AKHR	39..328	CDD:320504	112/299 (37%)
		TM helix 1	40..66	CDD:320504	7/26 (27%)
		TM helix 2	74..101	CDD:320504	11/26 (42%)
		TM helix 3	112..142	CDD:320504	12/29 (41%)
		TM helix 4	151..172	CDD:320504	11/20 (55%)
		TM helix 5	200..229	CDD:320504	8/28 (29%)
		TM helix 6	256..286	CDD:320504	16/29 (55%)
		TM helix 7	298..323	CDD:320504	11/24 (46%)
gnrhr2	NP_001138451.1	7tmA_GnRHR_vertebrate	45..336	CDD:320505	110/297 (37%)
		TM helix 1	46..72	CDD:320505	7/25 (28%)
		TM helix 2	79..106	CDD:320505	12/28 (43%)
		TM helix 3	117..147	CDD:320505	12/29 (41%)
		TM helix 4	158..179	CDD:320505	11/20 (55%)
		TM helix 5	207..236	CDD:320505	8/28 (29%)
		TM helix 6	262..292	CDD:320505	16/29 (55%)
		TM helix 7	305..330	CDD:320505	11/24 (46%)