DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AkhR and gnrhr2/nmi

DIOPT Version :9

Sequence 1:	NP_995639.1	Gene:	AkhR / 33942	FlyBaseID:	FBgn0025595	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001107548.1	Gene:	gnrhr2/nmi / 100135416	-ID:	-	Length:	373	Species:	Xenopus tropicalis

Alignment Length:	380	Identity:	127/380 - (33%)
Similarity:	209/380 - (55%)	Gaps:	42/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VNDTNGTIHLTKDMVFNDGH-------------RLSITVYSILFVISTIGNSTVLYLLTKRRLRG 70
            ||.|..|:.::::.....|:             ::.:.|....|:|::..|..||..::.:|.:.
Frog     8 VNQTESTLVISENNASASGNPDPWTEPTFTLAAKVRVGVTCCFFLIASFSNVAVLCSISGKRCKS 72

  Fly    71 PLRIDIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISL 135
            .||  ::::.|::|||:||.|:||::.:|...|||.:.:|.|::::|.::|.:|.::.|:|.|||
Frog    73 HLR--VLILSLSVADLLVTFLVMPLDALWNVMVQWYAGELSCKVLNFGKLFAMYSAALVLVVISL 135

  Fly   136 DRYFAILKPLK--RSYNRGRIMLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDF 198
            ||::|||.||.  .:..|.||||..||:.|::.:.||.|||.|...|.| .:.||....||...:
Frog   136 DRHWAILYPLSFTSAGQRNRIMLWTAWITSLLLASPQLFLFRLRTAPGV-NFTQCATHGSFTQHW 199

  Fly   199 DEKLYQAASMCSMYAFPLIMFIYCYGAIYLEIYRKSQRVLKDVIAERFRRSNDDVLSRAKKRTLK 263
            .|..|...:.|:::..||::.|.||..|..||.::.:.  |:.:|    ||.:|::|:|:.:|||
Frog   200 QETAYNMFTFCTLFVTPLVVMIVCYTRILWEIGKQMKH--KNELA----RSKNDLISKARLKTLK 258

  Fly   264 MTITIVIVFIICWTPYYTISMWYWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRM 328
            ||:.||:.|::||||||.:.:|||.......:....|..:||:|...::|.:|||||||
Frog   259 MTLVIVVSFMVCWTPYYLLGLWYWFQPEMINQTPEYLNHSLFLFGLLHTCTDPLVYGLY------ 317

  Fly   329 NNNNPSVNN------RHTS--LSNRLDSSNQLMQKQLTNNSLLNGRGQVMAAAVS 375
               .||...      |..|  ||.|..:|.||...:|....|.:..|. |:.||:
Frog   318 ---TPSFKEDLRSWIRRVSSLLSRRAKNSKQLAGSELNIKDLTSMEGP-MSTAVT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AkhR	NP_995639.1	7tm_1	55..319	CDD:278431	98/265 (37%)
gnrhr2/nmi	NP_001107548.1	7tmA_GnRHR_vertebrate	41..325	CDD:320505	108/301 (36%)
		TM helix 1	42..68	CDD:320505	6/25 (24%)
		TM helix 2	74..101	CDD:320505	12/28 (43%)
		TM helix 3	112..142	CDD:320505	12/29 (41%)
		TM helix 4	153..174	CDD:320505	10/20 (50%)
		TM helix 5	201..230	CDD:320505	9/28 (32%)
		TM helix 6	251..281	CDD:320505	15/29 (52%)
		TM helix 7	293..318	CDD:320505	12/33 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2980
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80348
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	1	1.000	-	-		FOG0003145
OrthoInspector	1	1.000	-	-		otm47960
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070