Protein Alignment AkhR and gnrhr2

DIOPT Version :10

• Sequence 1: NP_995639.1
• Gene: AkhR / 33942
• FlyBaseID: FBgn0025595
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001107547.1
• Gene: gnrhr2 / 100135415
• XenbaseID: XB-GENE-5867415
• Length: 410
• Species: Xenopus tropicalis
• Alignment Length: 350
• Identity: 117/350 - (33%)
• Similarity: 191/350 - (54%)
• Gaps: 21/350 - (6%)

  Fly    34 FNDGHRLSITVYSILFVISTIGNSTVLYLLTKRRLRGPLRIDIMLMHLAIADLMVTLLLMPMEIV 98
            |:...:..:.:..::|.:|...|..|::..|....:....:.|::::|..|||:||.::||::.:
 Frog    47 FSPAAKARVIITFVIFALSAFCNLAVVWASTNTSRKKRSHVRILILNLTTADLLVTFIVMPLDAI 111

  Fly    99 WAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAILKPL--KRSYNRGRIMLACAWL 161
            |..||||.:.||.||::.|.::..:|..::|.|.||:||..|||.||  ..:..|.:|||:.|||
 Frog   112 WNITVQWQAGDLACRILMFLKLLSMYSCAFVTVVISIDRQSAILNPLGISEAKKRNKIMLSVAWL 176

  Fly   162 GSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAI 226
            .|::.|:||.||||.........:.||....||:..:.|.:|...|...::..||::.|.||..|
 Frog   177 MSILLSLPQLFLFHTVTITEPQNFTQCTTRGSFQEHWQETVYNMVSFVCLFLLPLLIMISCYSRI 241

  Fly   227 YLEIYRKSQRVLKDVIAER---FRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWL 288
            .:||   |:|:.|..::.:   .|||.::: .:|:.|||||:|.||..|||||||||.:.:|||.
 Frog   242 LIEI---SRRMSKGALSSKEVYLRRSKNNI-PKARMRTLKMSIVIVSSFIICWTPYYLLGLWYWF 302

  Fly   289 -DKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRMNNNNPSVNNRHTSLSNRLDSSNQL 352
             .:....:::..|...||||...|:|::|:.|||:.|..|...:......|    ::.||:|:.:
 Frog   303 YPEAMEERVSQSLTHILFIFGLVNACLDPITYGLFTIHFRKGLHRYCRGGR----ASDLDTSSSV 363

  Fly   353 -------MQKQLTNNSLLNGRGQVM 370
                   |........:||...|||
 Frog   364 TGSFRCSMSSFRAKKIVLNQELQVM 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AkhR	NP_995639.1	7tmA_AKHR	39..328	CDD:320504	105/294 (36%)
		TM helix 1	40..66	CDD:320504	5/25 (20%)
		TM helix 2	74..101	CDD:320504	10/26 (38%)
		TM helix 3	112..142	CDD:320504	11/29 (38%)
		TM helix 4	151..172	CDD:320504	11/20 (55%)
		TM helix 5	200..229	CDD:320504	9/28 (32%)
		TM helix 6	256..286	CDD:320504	18/29 (62%)
		TM helix 7	298..323	CDD:320504	11/24 (46%)
gnrhr2	NP_001107547.1	7tmA_GnRHR_vertebrate	52..345	CDD:320505	106/296 (36%)
		TM helix 1	53..79	CDD:320505	5/25 (20%)
		TM helix 2	87..114	CDD:320505	10/26 (38%)
		TM helix 3	125..155	CDD:320505	11/29 (38%)
		TM helix 4	166..187	CDD:320505	11/20 (55%)
		TM helix 5	215..244	CDD:320505	9/28 (32%)
		TM helix 6	270..300	CDD:320505	18/29 (62%)
		TM helix 7	313..338	CDD:320505	11/24 (46%)