DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and thbs4

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001072673.1	Gene:	thbs4 / 780130	XenbaseID:	XB-GENE-1008367	Length:	955	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	376/808 - (46%)
Similarity:	469/808 - (58%)	Gaps:	90/808 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 GDCEDALARSLSDLLALVKLLREDVAHQRQEIAYLRMLLENCAGCKNPLTTDNQLRIEPDCRSAN 306
            ||....|...::.:..|:..||:.:..|.:|..:||..:..|..|  .|..|..|..|...|...
Frog   215 GDVSRQLIGQITQMNQLLGELRDVMRQQVKETMFLRNTISECQAC--GLGPDYPLPTEAPKRQTT 277

  Fly   307 PCYPGVECLDSAAGPRCGHCPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDSCPAGYE 371
            ...|         .|||         |..|           |:.||:|.||..|.||..||.||.
Frog   278 TAPP---------KPRC---------DATS-----------CFRGVRCIDTGTGFQCGPCPEGYT 313

  Fly   372 GDGRTCSLRNPCLDTPCPSGAQCLQVGYPPYFHCISCPMGHEVNGTSCRDMNECLLYDPCDELAT 436
            |                                          ||..|.|::||.| :||.....
Frog   314 G------------------------------------------NGVICTDVDECRL-NPCFPGVR 335

  Fly   437 CTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFR---CPEHSTCINEI 498
            |.|.||||:|..||.|:.|:...|...::  ....:|.|.|::||..|  |   |..:|.|.|.:
Frog   336 CINTSPGFKCENCPPGYTGSTIQGIGINF--AKQNKQVCTDINECENG--RNGGCTANSLCTNTM 396

  Fly   499 GSYRC-QCHEGYVTNGTYSCLDRSSVFMCPDG-TVCDRNAVCLRMDNIRHKCHCNVGWAGNGLIC 561
            ||:|| .|..|||.:....|....|   |..| :.|..:|.|....:....|.|:|||||||.:|
Frog   397 GSFRCGACKPGYVGDQIKGCKTEKS---CRRGQSPCHASAQCSEEKDGDITCTCSVGWAGNGYLC 458

  Fly   562 GRDTDVDGWPDQAIGCPELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLA 626
            |:|||:||:||:|:.||:..|::|||..:|||||||.|.|..||.||:|||||.:.|.||||.|.
Frog   459 GKDTDIDGYPDEALPCPDKNCKKDNCVYVPNSGQEDTDRDSIGDACDEDADGDGILNEQDNCVLV 523

  Fly   627 YNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQS 691
            .|.:|.:||.|..||.||||.|..|..|.|||.||.||.||.|:|.|.|.|.||||..:||..|.
Frog   524 ANIDQKNSDQDIFGDACDNCRLTLNNDQRDTDNDGKGDACDDDMDGDGIKNILDNCQRVPNVDQK 588

  Fly   692 DVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDG 756
            |.|.||||||||:||::.||:|.|.|.|.|||:|..:.|.|.||..:|.||||.|.||.|||||.
Frog   589 DKDGDGVGDACDSCPDIINPNQSDIDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSSQLDTDK 653

  Fly   757 DGTGDECDDDMDGDGIPNY----KDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPN 817
            ||.|||||||.|.||||:.    .|||.|..||.|:|.|.:|.||.||.|.|.|.|.:.:|.||.
Frog   654 DGLGDECDDDDDNDGIPDTVPPGPDNCRLVPNPGQEDDNNDGVGDVCEADFDQDTVIDRIDVCPE 718

  Fly   818 NSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFY 882
            |:.|..||||..||:.|||:|.:|.||||:|...|.|||||:|||||||||..||.||||:|||:
Frog   719 NAEITLTDFRAYQTVVLDPEGDAQIDPNWIVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFH 783

  Fly   883 INDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRN 947
            :|..||||||||:|.||.|..:|||.||:..||||:..||.|.|.||||:|.|.|..|||..:||
Frog   784 VNTVTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKSGPGEHLRN 848

  Fly   948 SLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTL 1012
            :|||.|:|:.:.|||||||:|:.||::.||||.|.|||.:|.||.:.:||:.|:.|||...|:|:
Frog   849 ALWHTGDTNDQVRLLWKDPRNVGWKDKVSYRWFLQHRPQVGYIRARFYEGSELVADSGVTVDTTM 913

  Fly  1013 KGGRLGVFCFSQRMIIWSNLQYKCNNRV 1040
            :|||||||||||..||||||:|:||:.:
Frog   914 RGGRLGVFCFSQENIIWSNLKYRCNDTI 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	17/39 (44%)
		TSP3 repeat_1C	563..595	CDD:275367	17/31 (55%)
		TSP3 repeat_short	632..654	CDD:275365	11/21 (52%)
		TSP_3	656..690	CDD:280556	20/33 (61%)
		TSP3 repeat_long	656..690	CDD:275366	20/33 (61%)
		TSP3 repeat_short	691..713	CDD:275366	14/21 (67%)
		TSP3 repeat_long	714..751	CDD:275365	19/36 (53%)
		TSP_3	715..751	CDD:280556	19/35 (54%)
		TSP3 repeat_short	752..787	CDD:275366	24/38 (63%)
		TSP_3	789..822	CDD:280556	15/32 (47%)
		TSP_C	841..1038	CDD:283408	121/196 (62%)
		coiled coil	245..286	CDD:293927	9/40 (23%)
		TSPcc_insect	245..286	CDD:293927	9/40 (23%)
		EGF_CA	343..377	CDD:214542	14/33 (42%)
		EGF_CA	421..457	CDD:238011	17/35 (49%)
thbs4	NP_001072673.1	LamG	24..192	CDD:389952
		coiled coil	217..260	CDD:293926	10/44 (23%)
		TSP-4cc	217..260	CDD:293926	10/44 (23%)
		EGF_CA	321..356	CDD:238011	17/35 (49%)
		EGF_3	378..411	CDD:372403	15/34 (44%)
		EGF_CA	422..458	CDD:389777	14/35 (40%)
		TSP3 repeat_short	460..492	CDD:275365	17/31 (55%)
		MSCRAMM_SdrC	<461..652	CDD:380146	110/190 (58%)
		TSP_3	493..528	CDD:367074	20/34 (59%)
		TSP3 repeat_long	493..528	CDD:275366	20/34 (59%)
		TSP3 repeat_short	529..551	CDD:275366	11/21 (52%)
		TSP3 repeat_long	552..587	CDD:275365	20/34 (59%)
		TSP3 repeat_short	588..610	CDD:275365	14/21 (67%)
		TSP3 repeat_long	611..648	CDD:275365	19/36 (53%)
		TSP_3	612..648	CDD:367074	19/35 (54%)
		TSP3 repeat_short	649..688	CDD:275366	24/38 (63%)
		TSP_3	689..723	CDD:367074	15/33 (45%)
		TSP3 repeat_long	689..720	CDD:275365	14/30 (47%)
		TSP_C	742..939	CDD:368586	121/196 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I574
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49112
Panther	1	1.100	-	-	LDO	PTHR10199
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4962
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.190