DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsp and THBS1

DIOPT Version :9

Sequence 1:NP_001137802.1 Gene:Tsp / 33941 FlyBaseID:FBgn0031850 Length:1060 Species:Drosophila melanogaster
Sequence 2:NP_003237.2 Gene:THBS1 / 7057 HGNCID:11785 Length:1170 Species:Homo sapiens


Alignment Length:1203 Identity:409/1203 - (33%)
Similarity:569/1203 - (47%) Gaps:277/1203 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 VDVASLSLDPVASAELEQFI-----RKGDVVISTRHIRPRRKLHISIEALFMIDFPMLKHK-MSF 77
            ::.|:| :.||...:.:..:     .||.:::::  :|..:|...::.||...|     |. ..|
Human    61 IEDANL-IPPVPDDKFQDLVDAVRAEKGFLLLAS--LRQMKKTRGTLLALERKD-----HSGQVF 117

  Fly    78 FLDRKQQRVTLDISANGATESRNFEIPNINE----TSTIRSLALQFSKNRITLHVDCKASTHHDI 138
            .:....:..|||:|   .|......:.::.|    |...:|:.|...::|..|::||:...:.::
Human   118 SVVSNGKAGTLDLS---LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAEL 179

  Fly   139 DMNLAKLYTQMDDPVIKLFRERKYPLHFDGDMEHSLQRANCQKGNHRRGNRRMLRN-----KITE 198
            |:.:..::|:                    |:. |:.|....||......:.:|:|     ..|.
Human   180 DVPIQSVFTR--------------------DLA-SIARLRIAKGGVNDNFQGVLQNVRFVFGTTP 223

  Fly   199 RE--KNK------------KRDVRGWYEPTIAREGVVDHRHQEVPTDVERGDIPVLNG-DCED-- 246
            .:  :||            ..:|.....|.| |...:.|:.:         |:..:.| .|::  
Human   224 EDILRNKGCSSSTSVLLTLDNNVVNGSSPAI-RTNYIGHKTK---------DLQAICGISCDELS 278

  Fly   247 ALARSLSDLLALVKLLRED---VAHQRQEIA-YLR-----------------MLLENC--AGCKN 288
            ::...|..|..:|..|::.   |..:.:|:| .||                 ..:::|  ..|:|
Human   279 SMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQN 343

  Fly   289 PLTTDNQLRIE---------PDCRSANPCYP-----------------------GVE-------- 313
            .:|...::...         ||......|:|                       |::        
Human   344 SVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDS 408

  Fly   314 ----CLDSAAGPRCGH---CPLGFIGDG------------KSCKPGVTCAHHMC-YPGVQCHDTV 358
                |..|:...|..|   |...|..||            .:|..||.....:| .|..|    :
Human   409 LNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQ----M 469

  Fly   359 NGAQC------------DSCP-------------------AGYEGDGRTCSLRNP---------- 382
            ||..|            |:||                   .|.:...|.|:...|          
Human   470 NGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGD 534

  Fly   383 ----------------CLDTPCPSGAQCLQVGYPP-YFHCISCPMGHEVNGTSCRDMNECL-LYD 429
                            ||..||.:|.:|  ..||. .:.|.:||.|:..||..|.|::||. :.|
Human   535 VTENQICNKQDCPIDGCLSNPCFAGVKC--TSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPD 597

  Fly   430 PC---DELATCTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEH 491
            .|   :....|.|..||:.|.|||..|.|:...|                          :..||
Human   598 ACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFG--------------------------QGVEH 636

  Fly   492 STCINEIGSYRCQCHEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNI---RHKCHCNVG 553
            :|...::...|..|     |:||:.               |::||.|..:.:.   .::|.|..|
Human   637 ATANKQVCKPRNPC-----TDGTHD---------------CNKNAKCNYLGHYSDPMYRCECKPG 681

  Fly   554 WAGNGLICGRDTDVDGWPDQAIGC---PELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDN 615
            :||||:|||.|||:||||::.:.|   ....|::||||.||||||||.|.||.||.||||.|.|.
Human   682 YAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDK 746

  Fly   616 VQNSQDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALD 680
            :.:.:|||...||..|.|.|.|.|||.||||...:||.|.|||.:|.||.|..|||.|.|.|..|
Human   747 IPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERD 811

  Fly   681 NCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPM 745
            ||..:.|..|.|.|.|||||.|||||...||||.|.|.|.:||.|..:.|.|:||..|:|||||.
Human   812 NCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPY 876

  Fly   746 VSNSDQLDTDGDGTGDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPN 810
            |.|::|.|.|.||.||.||.|.|.||||:.||||.|..||.|.|.:.:|:||:|:||.|.|.||:
Human   877 VPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPD 941

  Fly   811 GMDNCPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGV 875
            ..|.||.|..|..||||..|.|||||||.||.||||||...|.|:|||:|.|||||||.|.|..|
Human   942 IDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAV 1006

  Fly   876 DFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEG 940
            ||.|||:||.:.|||||||||.||||.::|||.||:.||:||:..|..|....|:.:|:||||.|
Human  1007 DFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTG 1071

  Fly   941 PGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSG 1005
            ||..:||:|||.|||.|:.|.||.||::|.||:.|:|||.|.|||..|.||:.|:||.:::.|||
Human  1072 PGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSG 1136

  Fly  1006 NVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCNN 1038
            .::|.|..|||||:|.|||.|:.:|:|:|:|.:
Human  1137 PIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TspNP_001137802.1 EGF_CA 477..513 CDD:284955 6/35 (17%)
TSP3 repeat_1C 563..595 CDD:275367 17/34 (50%)
TSP3 repeat_short 632..654 CDD:275365 12/21 (57%)
TSP_3 656..690 CDD:280556 17/33 (52%)
TSP3 repeat_long 656..690 CDD:275366 17/33 (52%)
TSP3 repeat_short 691..713 CDD:275366 14/21 (67%)
TSP3 repeat_long 714..751 CDD:275365 18/36 (50%)
TSP_3 715..751 CDD:280556 18/35 (51%)
TSP3 repeat_short 752..787 CDD:275366 21/34 (62%)
TSP_3 789..822 CDD:280556 15/32 (47%)
TSP_C 841..1038 CDD:283408 113/196 (58%)
coiled coil 245..286 CDD:293927 10/65 (15%)
TSPcc_insect 245..286 CDD:293927 10/65 (15%)
EGF_CA 343..377 CDD:214542 11/65 (17%)
EGF_CA 421..457 CDD:238011 15/39 (38%)
THBS1NP_003237.2 TSPN 26..221 CDD:214560 35/191 (18%)
Heparin-binding 47..95 6/36 (17%)
VWC 318..372 CDD:278520 6/53 (11%)
TSP_1 383..428 CDD:395043 5/44 (11%)
TSP1 438..490 CDD:214559 10/55 (18%)
TSP1 495..547 CDD:214559 4/51 (8%)
EGF_3 650..689 CDD:403986 15/58 (26%)
TSP type-3 1 691..726 17/34 (50%)
TSP3 repeat_1C 691..726 CDD:275367 17/34 (50%)
TSP type-3 2 727..762 18/34 (53%)
TSP type-3 3 763..785 12/21 (57%)
TSP3 repeat_short 763..785 CDD:275365 12/21 (57%)
TSP type-3 4 786..821 17/34 (50%)
TSP_3 786..821 CDD:367074 17/34 (50%)
TSP3 repeat_long 787..821 CDD:275366 17/33 (52%)
TSP type-3 5 822..844 14/21 (67%)
TSP3 repeat_short 822..844 CDD:275366 14/21 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..934 51/94 (54%)
TSP3 repeat_long 845..882 CDD:275365 18/36 (50%)
TSP_3 846..882 CDD:367074 18/35 (51%)
TSP3 repeat_short 883..918 CDD:275366 21/34 (62%)
TSP type-3 8 919..954 16/34 (47%)
TSP_3 919..952 CDD:367074 15/32 (47%)
Cell attachment site. /evidence=ECO:0000305 926..928 0/1 (0%)
TSP_C 972..1169 CDD:399035 113/196 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157232
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2CMRF
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D120983at2759
OrthoFinder 1 1.000 - - FOG0001167
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101187
Panther 1 1.100 - - O PTHR10199
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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