Protein Alignment Tsp and THBS1

DIOPT Version :10

• Sequence 1: NP_523495.2
• Gene: Tsp / 33941
• FlyBaseID: FBgn0031850
• Length: 1060
• Species: Drosophila melanogaster
• Sequence 2: NP_003237.2
• Gene: THBS1 / 7057
• HGNCID: 11785
• Length: 1170
• Species: Homo sapiens
• Alignment Length: 184
• Identity: 40/184 - (21%)
• Similarity: 64/184 - (34%)
• Gaps: 67/184 - (36%)

  Fly   150 DAEPKTFQIVRVKDIVYHPAYN-----PTTLNYDVAMLVLEDRLKFDTHIGSICLDENDVVPSAS 209
            :|||.|            |.||     .|.|:.|::..:       |.|           .|..|
Human    41 EAEPLT------------PTYNISANGLTELHDDLSTYM-------DGH-----------TPEGS 75

  Fly   210 YENCVTTGWGKEVLKTESQSQLQRNGFAPESHICGRPSGDA----CEVDVGSALACADTSGTYYL 270
            ..:...:.:..::..:..||.|..||..||. ||.......    |....|      :||.|..:
Human    76 KADSAVSSFYLDIQPSPDQSGLDINGIKPEP-ICDYTPASGFFPYCSFTNG------ETSPTVSM 133

  Fly   271 KGV-YSADNGCNRPDQIVSFSNIDV-QWIKQALKNPNQFIT-------PVPNYQ 315
            ..: :.|.|        :|.|:::. |::::.|    |.||       .:.|||
Human   134 AELEHLAQN--------ISKSHLETCQYLREEL----QQITWQTFLQEEIENYQ 175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_523495.2	coiled coil	245..286	CDD:293927	7/45 (16%)
		TSPcc_insect	245..286	CDD:293927	7/45 (16%)
		EGF_CA	421..457	CDD:238011
		EGF_CA	477..508	CDD:429571
		TSP3 repeat_1C	563..595	CDD:275367
		TSP3 repeat_short	632..654	CDD:275365
		TSP_3	656..690	CDD:367074
		TSP3 repeat_long	656..690	CDD:275366
		TSP3 repeat_short	691..713	CDD:275366
		TSP_3	714..751	CDD:367074
		TSP3 repeat_long	714..751	CDD:275365
		TSP3 repeat_short	752..787	CDD:275366
		TSP_3	789..822	CDD:367074
		TSP_C	841..1037	CDD:461725
THBS1	NP_003237.2	TSPN	26..221	CDD:214560	40/184 (22%)
		Heparin-binding	47..95		10/65 (15%)
		VWC	318..372	CDD:278520
		TSP_1	383..428	CDD:459668
		TSP1	438..490	CDD:214559
		TSP1	495..547	CDD:214559
		Involved in retention in extracellular matrix (ECM), involved in trimer formation. /evidence=ECO:0000269|PubMed:18285447	531..1152
		EGF_3	650..689	CDD:463759
		TSP3 repeat_1C	691..726	CDD:275367
		TSP3 repeat_short	763..785	CDD:275365
		TSP_3	786..821	CDD:367074
		TSP3 repeat_long	787..821	CDD:275366
		TSP3 repeat_short	822..844	CDD:275366
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	839..934
		TSP3 repeat_long	845..882	CDD:275365
		TSP_3	846..882	CDD:367074
		TSP3 repeat_short	883..918	CDD:275366
		TSP_3	919..952	CDD:367074
		Cell attachment site. /evidence=ECO:0000305	926..928
		TSP_C	972..1169	CDD:461725