DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and Nell2

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001276582.1	Gene:	Nell2 / 54003	MGIID:	1858510	Length:	819	Species:	Mus musculus

Alignment Length:	994	Identity:	216/994 - (21%)
Similarity:	322/994 - (32%)	Gaps:	345/994 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TRVLL------IGLTALALTFVDVASLSLDPVASAELEQFIRKGDVVISTRHIRPRRKLHISIEA 62
            :||||      :||.|:....|| .||.:|.:...||.:         ||..:|....||...:|
Mouse     6 SRVLLRTFCVILGLGAVWGLGVD-PSLQIDVLTELELGE---------STDGVRQVPGLHNGTKA 60

  Fly    63 LFMIDFPMLKHKMSFFLDRKQQRVTLDISANGATESRNFE-IPNINETSTI-------------- 112
                           ||.::..|   .|.|:.||..|.|: :.|.:|.:.:
Mouse    61 ---------------FLFQESPR---SIKASTATAERFFQKLRNKHEFTILVTLKQIHLNSGVIL 107

  Fly   113 -------RSLALQFS--KNRITLHVDCKASTHHDIDMNLAKLYTQMDDPVIKLFRERKYPLHFDG 168
                   |.|.|:.|  :|.|.||.  ::.||        :.:|::...::...:..|..|.|..
Mouse   108 SIHHLDHRYLELESSGHRNEIRLHY--RSGTH--------RPHTEVFPYILADAKWHKLSLAFSA 162

  Fly   169 DMEHSLQRANCQKGNHRRGNRRMLRNKITERE---------------KNKKRDVRGWYEPTIARE 218
              .|.:...:|              |||.||.               ..::.:..|::      :
Mouse   163 --SHLILHIDC--------------NKIYERVVEMPSTDLPLGTTFWLGQRNNAHGYF------K 205

  Fly   219 GVVDHRHQEVPTDVERGDIPVLNGDCEDA--------LARSLSDLLA--LVKLLREDVAHQRQEI 273
            |::...|..|.........|.||..|...        ....|.|:|:  ..||.|.:....|.:.
Mouse   206 GIMQDVHVLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILSKTSAKLSRAEQRMNRLDQ 270

  Fly   274 AYLRMLLENCA--------------GCKNPLTTDNQLRIE------PDC--RSANPCYPGVECLD 316
            .|..   ..|.              ||||....:..::.|      |||  :|| |.|.
Mouse   271 CYCE---RTCTVKGTTYRESESWTDGCKNCTCLNGTIQCETLVCPAPDCPPKSA-PAYV------ 325

  Fly   317 SAAGPRCGHCPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDSCPAGY-EGDGRTC-SL 379
                            |||.||              :|..|     |......| ||:..|. |.
Mouse   326 ----------------DGKCCK--------------ECKST-----CQFQGRSYFEGERNTVYSS 355

  Fly   380 RNPCLDTPCPSGAQCL--QVGYPPYFHCISCPMGHEV--NGTSCRDMNECLLYDPCDELAT---- 436
            ...|:...|......|  .:|.||    :.||..|::  :.:.|:   .|..||.|.|..|
Mouse   356 SGMCVLYECKDQTMKLVENIGCPP----LDCPESHQIALSHSCCK---VCKGYDFCSEKHTCMEN 413

  Fly   437 --CTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIG 499
              |.||:....|| |..||........:            |.|:|||..|...|.|::.|:|..|
Mouse   414 SVCRNLNDRAVCS-CRDGFRALREDNAY------------CEDIDECAEGRHYCRENTMCVNTPG 465

  Fly   500 SYRCQCHEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAGNGLIC--- 561
            |:.|.|..||:....|||.:..........  ||.||:|..... .|.|.|..|:.|||..|
Mouse   466 SFMCICKTGYIRIDDYSCTEHDECLTNQHN--CDENALCFNTVG-GHNCVCKPGYTGNGTTCKAF 527

  Fly   562 --------------------------GRDTDVDGWPDQAIGCPELRCQRDNCPKLP-------NS 593
                                      ..:||:|...:..:.|.    .|.||..||       ..
Mouse   528 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSEGFVQCD----SRANCINLPGWYHCECRD 588

  Fly   594 GQEDADLDG-HGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDT 657
            |..|..:.. .|:.|:|..:....::|..|..:.:|   ||...|     | .|     |.
Mouse   589 GYHDNGMFAPGGESCEDIDECGTGRHSCTNDTICFN---LDGGYD-----C-RC-----PH---- 635

  Fly   658 DEDGLGDECDGD---------------IDNDSIPNALDNCP---LLPNPSQSDVDNDGVG-DACD 703
                 |..|.||               ::||..  ::.:|.   ::......|.:|..|. ..|.
Mouse   636 -----GKNCTGDCVHEGKVKHTGQIWVLENDRC--SVCSCQTGFVMCRRMVCDCENPTVDLSCCP 693

  Fly   704 NC-PNLPNP--DQKDRDMDFVGDACHRD------IDGDDDGVPNSLDNCPMVSNSDQLDTDGDGT 759
            .| |.|.:.  .|....:...||...:|      :.|:.|..|.:   ||.|
Mouse   694 ECDPRLSSQCLHQNGETVYNSGDTWVQDCRQCRCLQGEVDCWPLA---CPEV------------- 742

  Fly   760 GDECDDDMDGDGIPNYKDNCP-LAKNPKQDDFNRNGKGDSCEDDEDV------DGVPNGMD---- 813
              ||:..:    :|. .:.|| ...:|.|.|..||....:|.|:.:|      ..:.:|.:
Mouse   743 --ECEFSV----LPE-NECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 800

  Fly   814 NCPNNSMIHHTDFRTLQTI 832
            .|.|..:....|.:.||.:
Mouse   801 QCKNGHLCCSVDPQCLQEL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	15/35 (43%)
		TSP3 repeat_1C	563..595	CDD:275367	9/38 (24%)
		TSP3 repeat_short	632..654	CDD:275365	6/21 (29%)
		TSP_3	656..690	CDD:280556	7/51 (14%)
		TSP3 repeat_long	656..690	CDD:275366	7/51 (14%)
		TSP3 repeat_short	691..713	CDD:275366	7/25 (28%)
		TSP3 repeat_long	714..751	CDD:275365	9/42 (21%)
		TSP_3	715..751	CDD:280556	9/41 (22%)
		TSP3 repeat_short	752..787	CDD:275366	6/35 (17%)
		TSP_3	789..822	CDD:280556	9/42 (21%)
		TSP_C	841..1038	CDD:283408
		coiled coil	245..286	CDD:293927	9/64 (14%)
		TSPcc_insect	245..286	CDD:293927	9/64 (14%)
		EGF_CA	343..377	CDD:214542	6/34 (18%)
		EGF_CA	421..457	CDD:238011	14/41 (34%)
Nell2	NP_001276582.1	TSPN	32..217	CDD:214560	45/243 (19%)
		VWC	277..333	CDD:327433	18/92 (20%)
		EGF_CA	443..>475	CDD:311536	13/31 (42%)
		EGF_3	489..524	CDD:372403	12/37 (32%)
		EGF_CA	558..592	CDD:214542	9/37 (24%)
		EGF_CA	605..>636	CDD:311536	10/53 (19%)
		VWC	708..758	CDD:327433	14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910