DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and thbs3

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001011401.1	Gene:	thbs3 / 496875	XenbaseID:	XB-GENE-5761978	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	408/1007 - (40%)
Similarity:	535/1007 - (53%)	Gaps:	180/1007 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DRKQQRVTLDISANGATESRNFEIPNINETSTIRSLALQFSKNRITLHVDCKASTHHDIDMNLAK 144
            |.|...|:|        ::.|....|:: |..:|....:.....:.|:||||     .:|.:|.
Frog   107 DSKLHAVSL--------QNANLSDGNMH-TMILRVSGFRGDTLSLELYVDCK-----QVDTSLG- 156

  Fly   145 LYTQMDDPVIKLFRERKYPLHFDGDMEHSLQRANCQKGNHRRGNRRMLRNKITEREKNKKRDVRG 209
            |...|..|..::                       :.|:.|.|::..||             ::|
Frog   157 LPEMMIIPQFEV-----------------------ESGDIRSGHKAYLR-------------MQG 185

  Fly   210 WYEP-------TIAREGVVDHRHQEVPTDVERGDIPVLNGDCEDALARSLSDLLALVKL------ 261
            ..|.       :::|.|.:    .|.|...:......:||.....|......|:|.:.|
Frog   186 SVESMKLILGGSLSRVGAL----SECPFQEDESIHNTVNGVVNSILGEHTKALIAQMTLFNKVLA 246

  Fly   262 -LREDVAHQRQEIAYLRMLLENCAGCKNPLTTDNQLRIEPDCRSANPCYPGVECLDSAAGPRCGH 325
             ||||:..|.:|::.:|..:..|..|.   ..:::.|..|     |||:.||:|:::..
Frog   247 ELREDIRDQVKEMSLIRNTIMECQVCG---FHEHRSRCNP-----NPCFQGVDCMETYE------ 297

  Fly   326 CPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDSCPAGYEGDGRTCSLRNPCLDTPCPS 390
                                   |||.:|                               .|||.
Frog   298 -----------------------YPGFRC-------------------------------GPCPP 308

  Fly   391 GAQCLQVGYPPYFHCISCPMGHEVNGTSCRDMNECLLYDPCDELATCTNLSPGFQCSPCPVGFDG 455
            |:|                    .|||.|.|::||...:||...:.|.|.||||:|..||.|:.|
Frog   309 GSQ--------------------GNGTHCADIDECSHANPCFSGSKCINTSPGFRCEHCPRGYKG 353

  Fly   456 THAHGYFADYYSVDYRRQTCLDVDECRTG-FFRCPEHSTCINEIGSYRC-QCHEGYVTNGTYSCL 518
            ....|...||....  :|.|.|:|||..| ...|..:|.|.|.:||:|| .|..|:|.|.|..|.
Frog   354 NTVSGVGVDYAKAS--KQVCKDIDECNDGNNGGCDANSICTNTVGSFRCGPCKPGFVGNQTVGCA 416

  Fly   519 DRSSVFMC--PDGTVCDRNAVCL--RMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQAIGCPE 579
            .:.|   |  |....|..|..|:  |..:|  .|.|||||||||..||||||:||:||:.:.|.:
Frog   417 PKKS---CASPAFNPCHLNGHCVFERSGDI--TCACNVGWAGNGYTCGRDTDLDGYPDEPMPCID 476

  Fly   580 --LRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDV 642
              ..|::|||...|||||||||.||.||.||:|||||.::|.:|||.|..|.:|.:||.|..||.
Frog   477 NNKHCRQDNCRLTPNSGQEDADNDGIGDQCDEDADGDGIKNVEDNCRLVPNKDQQNSDTDSFGDA 541

  Fly   643 CDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPN 707
            ||||....|..|.|||.:|.||.||.|||.|.|||.|||||.:|||.|:|.|.||||||||:||.
Frog   542 CDNCPNVPNNDQRDTDANGEGDACDNDIDGDGIPNMLDNCPKVPNPLQTDRDLDGVGDACDSCPE 606

  Fly   708 LPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGI 772
            ..||.|.|.|.|.|||.|..:.|.|.||..::.||||.:.||.|||:|.||.|||||.|.|.|||
Frog   607 ASNPTQADADSDLVGDMCDTNQDRDGDGHQDTKDNCPDIPNSSQLDSDNDGKGDECDQDDDNDGI 671

  Fly   773 PNY----KDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIP 833
            |:|    .|||.|..||.|.|.:.:|.||.||:|.|.|.|.:.:|.||.::.:..||||..||:.
Frog   672 PDYMPPGPDNCRLMHNPNQKDSDGDGVGDVCEEDFDNDTVIDPLDVCPESAEVTLTDFRAYQTVI 736

  Fly   834 LDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSY 898
            |||:|.:|.||||||...|.|||||:|||||||||..||.||||:|||::|..||||||||:|||
Frog   737 LDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFSY 801

  Fly   899 QSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLW 963
            |.|..:|||.||:..||||:..||.|.|.||:|:|.|.||.|||..:||:||:.|:|..:.||||
Frog   802 QDSSSFYVVMWKQTEQTYWQATPFRAVAEPGLQLKAVKSTTGPGEQLRNALWNTGHTQDQVRLLW 866

  Fly   964 KDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQRMII 1028
            |||:|:.||::|||||.|:|||.:|.||::::||..|:.|||.:.|:.::|||||||||||..||
Frog   867 KDPRNVGWKDKTSYRWQLMHRPQVGYIRVKLYEGVDLVADSGVIIDTNMRGGRLGVFCFSQENII 931

  Fly  1029 WSNLQYKCNNRVKPLIYNDLSDYLKTKVELQD 1060
            ||||||:||:.:.    .|...|.:...|.:|
Frog   932 WSNLQYRCNDTIP----EDFEPYRRGLQEGKD 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	16/37 (43%)
		TSP3 repeat_1C	563..595	CDD:275367	16/33 (48%)
		TSP3 repeat_short	632..654	CDD:275365	10/21 (48%)
		TSP_3	656..690	CDD:280556	23/33 (70%)
		TSP3 repeat_long	656..690	CDD:275366	23/33 (70%)
		TSP3 repeat_short	691..713	CDD:275366	14/21 (67%)
		TSP3 repeat_long	714..751	CDD:275365	17/36 (47%)
		TSP_3	715..751	CDD:280556	17/35 (49%)
		TSP3 repeat_short	752..787	CDD:275366	23/38 (61%)
		TSP_3	789..822	CDD:280556	13/32 (41%)
		TSP_C	841..1038	CDD:283408	123/196 (63%)
		coiled coil	245..286	CDD:293927	12/47 (26%)
		TSPcc_insect	245..286	CDD:293927	12/47 (26%)
		EGF_CA	343..377	CDD:214542	4/33 (12%)
		EGF_CA	421..457	CDD:238011	16/35 (46%)
thbs3	NP_001011401.1	LamG	<58..196	CDD:389952	25/139 (18%)
		coiled coil	230..272	CDD:293925	11/41 (27%)
		TSP-3cc	230..272	CDD:293925	11/41 (27%)
		EGF_CA	319..355	CDD:238011	16/35 (46%)
		EGF_3	381..410	CDD:372403	11/28 (39%)
		TSP3 repeat_short	460..494	CDD:275365	16/33 (48%)
		MSCRAMM_SdrC	<461..662	CDD:380146	114/200 (57%)
		TSP_3	495..530	CDD:367074	21/34 (62%)
		TSP3 repeat_long	495..530	CDD:275366	21/34 (62%)
		TSP3 repeat_short	531..553	CDD:275366	10/21 (48%)
		TSP_3	554..589	CDD:367074	23/34 (68%)
		TSP3 repeat_long	554..589	CDD:275366	23/34 (68%)
		TSP3 repeat_short	590..612	CDD:275366	14/21 (67%)
		TSP3 repeat_long	613..650	CDD:275365	17/36 (47%)
		TSP3 repeat_short	651..690	CDD:275366	23/38 (61%)
		TSP_3	691..725	CDD:367074	13/33 (39%)
		TSP_C	744..941	CDD:368586	123/196 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I574
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49112
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060