DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and Thbs1

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_038961572.1	Gene:	Thbs1 / 445442	RGDID:	1588455	Length:	1171	Species:	Rattus norvegicus

Alignment Length:	1134	Identity:	398/1134 - (35%)
Similarity:	536/1134 - (47%)	Gaps:	263/1134 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 MSFFLDRKQQRVTLDISANGATESRNFEIPNINETSTIRSLALQFSKNRITLHVDCKASTHHDID 139
            :|..|..|||.|:::.:              :..|...:|:.|...::|..|::||......::|
  Rat   130 LSLSLPGKQQVVSVEEA--------------LLATGQWKSITLFVQEDRAQLYIDCDKMESAELD 180

  Fly   140 MNLAKLYTQMDDPVIKLFRERKYPLHFDGDMEHSLQRANCQKGNHRRGN--RRMLRNK-----IT 197
            :.:..::|: |...:...|..|      ||:..:.|.. .|......|.  ..:||||     .|
  Rat   181 VPIQSIFTR-DLANVARLRVAK------GDVNDNFQGV-LQNVRFVFGTTPEDILRNKGCSSSAT 237

  Fly   198 EREKNKKRDVRGWYEPTIAREGVVDHRHQEVPTDVERGDIPVLNG-DCED--ALARSLSDLLALV 259
            ........:|.....|.| |...:.|:.:         |:..:.| .|::  ::...|..|..:|
  Rat   238 NVLLTLDNNVVNGSSPAI-RTNYIGHKTK---------DLQAICGLSCDELSSMVLELRGLRTIV 292

  Fly   260 KLLRED---VAHQRQEIA-YLR-----------------MLLENC--AGCKNPLTTDNQLRIEPD 301
            ..|::.   |..:.:|:| .||                 ..:::|  ..|:|.:|...::.. |.
  Rat   293 TTLQDSIRKVTEENRELASELRRPPLCFHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSC-PI 356

  Fly   302 CRSANPCYPGVECLDSAAGPRC--------------------GHCPLGFIGDGKSC--------- 337
            ...:|...|..||.     |||                    ..|..|....|:||
  Rat   357 MPCSNATVPDGECC-----PRCWPSDSADDGWSPWSEWTSCSATCGNGIQQRGRSCDSLNNRCEG 416

  Fly   338 --------------------------KPGVTCAHHMCYPGVQCHDTV--------------NGAQ 362
                                      .|..:|:       |.|.|.|              ||..
  Rat   417 SSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCS-------VTCGDGVITRIRLCNSPSPQMNGKP 474

  Fly   363 C------------DSCP-------------------AGYEGDGRTCSLRNP-------------- 382
            |            |:||                   .|.:...|.|:...|
  Rat   475 CEGEARETKACKKDACPINGGWSPWSLWDICSVTCGGGVQRRSRLCNNPTPQFGGKDCVGDVTEN 539

  Fly   383 ------------CLDTPCPSGAQCLQVGYPP-YFHCISCPMGHEVNGTSCRDMNECL-LYDPC-- 431
                        ||..||.:||:|  ..||. .:.|.:||.|:..||..|:|::||. :.|.|
  Rat   540 QVCNKQDCPIDGCLSNPCFAGAKC--TSYPDGSWKCGACPPGYSGNGIQCKDVDECKEVPDACFN 602

  Fly   432 -DELATCTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCI 495
             :....|.|..||:.|.|||..|.|:...|                          |..||:...
  Rat   603 HNGEHRCKNTDPGYNCLPCPPRFTGSQPFG--------------------------RGVEHAMAN 641

  Fly   496 NEIGSYRCQCHEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNI---RHKCHCNVGWAGN 557
            .::...|..|     |:||:.               |::||.|..:.:.   .::|.|..|:|||
  Rat   642 KQVCKPRNPC-----TDGTHD---------------CNKNAKCNYLGHYSDPMYRCECKPGYAGN 686

  Fly   558 GLICGRDTDVDGWPDQAIGC---PELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNS 619
            |:|||.|||:||||::.:.|   ....|::||||.||||||||.|.||.||.||||.|.|.:.:.
  Rat   687 GIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDD 751

  Fly   620 QDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPL 684
            :|||...||..|.|.|.|.|||.||||...:||.|.|||.:|.||.|..|||.|.|.|..|||..
  Rat   752 RDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAVDIDGDGILNERDNCQY 816

  Fly   685 LPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNS 749
            :.|..|.|.|.|||||.|||||...||||.|.|.|.:||.|..:.|.|:||..|:|||||.|.|:
  Rat   817 VYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNA 881

  Fly   750 DQLDTDGDGTGDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDN 814
            :|.|.|.||.||.||.|.|.||||:.:|||.|..||.|.|.:.:|:||:|:||.|.|.||:..|.
  Rat   882 NQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDHDNVPDIDDI 946

  Fly   815 CPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDG 879
            ||.|..|..||||..|.|||||||.||.||||||...|.|:|||:|.|||||||.|.|..|||.|
  Rat   947 CPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSG 1011

  Fly   880 TFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPM 944
            ||:||.:.|||||||||.||||.::|||.||:.||:||:..|..|....|:.:|:||||.|||..
  Rat  1012 TFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEH 1076

  Fly   945 MRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFD 1009
            :||:|||.|||.|:.|.||.||::|.||:.|:|||.|.|||..|.||:.|:||.:::.|||.::|
  Rat  1077 LRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD 1141

  Fly  1010 STLKGGRLGVFCFSQRMIIWSNLQYKCNN 1038
            .|..|||||:|.|||.|:.:|:::|:|.:
  Rat  1142 KTYAGGRLGLFVFSQEMVFFSDMKYECRD 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	6/35 (17%)
		TSP3 repeat_1C	563..595	CDD:275367	17/34 (50%)
		TSP3 repeat_short	632..654	CDD:275365	12/21 (57%)
		TSP_3	656..690	CDD:280556	17/33 (52%)
		TSP3 repeat_long	656..690	CDD:275366	17/33 (52%)
		TSP3 repeat_short	691..713	CDD:275366	14/21 (67%)
		TSP3 repeat_long	714..751	CDD:275365	18/36 (50%)
		TSP_3	715..751	CDD:280556	18/35 (51%)
		TSP3 repeat_short	752..787	CDD:275366	20/34 (59%)
		TSP_3	789..822	CDD:280556	15/32 (47%)
		TSP_C	841..1038	CDD:283408	112/196 (57%)
		coiled coil	245..286	CDD:293927	10/65 (15%)
		TSPcc_insect	245..286	CDD:293927	10/65 (15%)
		EGF_CA	343..377	CDD:214542	13/78 (17%)
		EGF_CA	421..457	CDD:238011	15/39 (38%)
Thbs1	XP_038961572.1	TSPN	26..221	CDD:214560	22/112 (20%)
		VWC	319..373	CDD:278520	10/59 (17%)
		TSP_1	384..429	CDD:395043	5/44 (11%)
		TSP1	439..491	CDD:214559	10/58 (17%)
		TSP1	496..548	CDD:214559	4/51 (8%)
		EGF_3	651..690	CDD:403986	15/58 (26%)
		TSP3 repeat_1C	692..727	CDD:275367	17/34 (50%)
		TSP3 repeat_short	764..786	CDD:275365	12/21 (57%)
		TSP_3	787..822	CDD:367074	17/34 (50%)
		TSP3 repeat_long	788..822	CDD:275366	17/33 (52%)
		TSP3 repeat_short	823..845	CDD:275366	14/21 (67%)
		TSP3 repeat_long	846..883	CDD:275365	18/36 (50%)
		TSP_3	847..883	CDD:367074	18/35 (51%)
		TSP3 repeat_short	884..919	CDD:275366	20/34 (59%)
		TSP_3	920..953	CDD:367074	15/32 (47%)
		TSP_C	973..1170	CDD:399035	112/196 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	1	1.100	-	-	O	PTHR10199
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920