DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp and Ism1

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001263418.1	Gene:	Ism1 / 319909	MGIID:	2442963	Length:	461	Species:	Mus musculus

Alignment Length:	355	Identity:	69/355 - (19%)
Similarity:	105/355 - (29%)	Gaps:	118/355 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   604 GDGCDD--DADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDEC 666
            |.|..|  ||...||..||     ..|...|:||                    .|.|.......
Mouse    26 GSGASDRQDAAAGNVSGSQ-----LQNNLNLESD--------------------STSETSFPLSK 65

  Fly   667 DGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDG 731
            :...::..:..........|......:..||......:.||.|             |....||:|
Mouse    66 EAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFP-------------DLSKADING 117

  Fly   732 DDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPNYKDNCP-----------LAK-- 783
            .:   ||......:|          ||...|.:.|...:..|::....|           ||:
Mouse   118 QN---PNIQVTIEVV----------DGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTN 169

  Fly   784 NPKQDDFNRNGKGDSCEDDEDVDGVPNGMDN-CPNNSMIHHTDFRTLQTIPLDPKGLSQADPNW- 846
            :..|||     |.||..||.:...||.|.|. .|.     |..|.|.:....|.   :..:.:|
Mouse   170 SGDQDD-----KYDSTSDDSNFLSVPRGWDRPAPG-----HRTFETKEQPEYDS---TDGEGDWS 221

  Fly   847 ------VVHANGTE-----------IVQTLNSD----PGLAVGKDAF-----------GGVDFDG 879
                  |...||.:           ..::...|    ||:   :|.|           |..:|:.
Mouse   222 LWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGI---EDTFRTAATEVSLLAGSEEFNA 283

  Fly   880 T--FYINDDTDDDYAGFVFSYQSSYKYYVV 907
            |  |.::.|:.:.:......:...|.:.|:
Mouse   284 TKLFEVDMDSCERWMSCKSEFLKKYMHKVI 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955
		TSP3 repeat_1C	563..595	CDD:275367
		TSP3 repeat_short	632..654	CDD:275365	3/21 (14%)
		TSP_3	656..690	CDD:280556	3/33 (9%)
		TSP3 repeat_long	656..690	CDD:275366	3/33 (9%)
		TSP3 repeat_short	691..713	CDD:275366	5/21 (24%)
		TSP3 repeat_long	714..751	CDD:275365	7/36 (19%)
		TSP_3	715..751	CDD:280556	7/35 (20%)
		TSP3 repeat_short	752..787	CDD:275366	8/47 (17%)
		TSP_3	789..822	CDD:280556	11/33 (33%)
		TSP_C	841..1038	CDD:283408	16/102 (16%)
		coiled coil	245..286	CDD:293927
		TSPcc_insect	245..286	CDD:293927
		EGF_CA	343..377	CDD:214542
		EGF_CA	421..457	CDD:238011
Ism1	NP_001263418.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..151		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..216		17/60 (28%)
		TSP1	218..259	CDD:214559	5/40 (13%)
		AMOP	286..449	CDD:128962	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930