DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and Thbs2

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001162609.1	Gene:	Thbs2 / 292406	RGDID:	1310979	Length:	1172	Species:	Rattus norvegicus

Alignment Length:	1174	Identity:	409/1174 - (34%)
Similarity:	544/1174 - (46%)	Gaps:	284/1174 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MLKHKMSFFL------DRKQQRVTLDISANGATESRNFEIPNINETSTI---------------- 112
            :.:.|..|||      ||| .|.||.:.....|..|.|||.:.....|:
  Rat    77 LARRKEGFFLTAQLKQDRK-SRGTLLVLEGPGTSQRQFEIVSNGPGDTLDLNYWVEGHQHTNFLE 140

  Fly   113 ---------RSLALQFSKNRITLHVDC--------KASTHHDIDMNLAKLYTQMDDPVIKLFRER 160
                     :::.:|.:.:..:|:|.|        :...:..::.:.:::|..........||..
  Rat   141 DVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEPFYEQLEADKSRMYVAKGASRESHFRGL 205

  Fly   161 KYPLH--FDGDMEHSLQRANCQKGNHRRGNRRMLRNKITEREKNKKRDVRGWYEPTIAREGVVDH 223
            ...:|  |...:|..|.:..||   |.:|           .|.|           ||:......|
  Rat   206 LQNVHLVFADSVEDILSKKGCQ---HSQG-----------AEVN-----------TISEHTETLH 245

  Fly   224 RHQEVPTD-----VERGDIPVLNGDCEDA--LARSLSDLLALVKLLREDVAHQRQEIAYL----- 276
            ....:.||     ||:.. .|....||:.  :...||.|..:|..|.:::.....:..:|
  Rat   246 LSPHITTDLVVQGVEKAQ-EVCTHSCEELSNMMNELSGLHVMVNQLSKNLERVSSDNQFLLELIG 309

  Fly   277 ---------------RMLLEN----------CAGCKNPLTTDNQLRIEPDCRSANPCYPGVECLD 316
                           |:..||          |. ||...|..||:...| ...|||.....||.
  Rat   310 GPLKTRNMSACVQEGRIFAENETWVVDSCTTCT-CKKFKTVCNQITCSP-ATCANPSLVEGECC- 371

  Fly   317 SAAGPRCGH--------------------CPLGFIGDGKSCK--------PGV---TCAHHMC-- 348
                |.|.|                    |..|....|:||.        |.:   ||:...|
  Rat   372 ----PSCSHSADNDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRTCSLGKCDT 432

  Fly   349 -----------YPGVQCHDT------------------VNGAQCD-------------------- 364
                       .|...|..|                  :.|..|.
  Rat   433 RIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKACQRAPCPIDGRW 497

  Fly   365 -----------SCPAGYEGDGRTCSLRNP--------------------------CLDTPCPSGA 392
                       :|..|.....|.|:...|                          ||..||..||
  Rat   498 SPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPCFPGA 562

  Fly   393 QCLQVGYPP-YFHCISCPMGHEVNGTSCRDMNEC-LLYDPC---DELATCTNLSPGFQCSPCPVG 452
            :|  ..:|. .:.|.|||:|...|||.|.|::|| ::.|.|   ::.:.|.|.:|||.|.|||..
  Rat   563 KC--NSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVADICFSINKASRCVNTNPGFHCLPCPPR 625

  Fly   453 FDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIGSYRCQCHEGYVTNGTYSC 517
            :.||...|...:  .....:|.|...:.|:.....|.:|:.||          :.|:.::..|
  Rat   626 YKGTQPFGIGLE--DAKTEKQVCEPENPCKDKTHNCHKHAECI----------YLGHFSDPMY-- 676

  Fly   518 LDRSSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQAIGC---PE 579
                                         ||.|..|:||:|||||.|:|:||||:..:.|   ..
  Rat   677 -----------------------------KCECQTGYAGDGLICGEDSDLDGWPNSNLVCATNAT 712

  Fly   580 LRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCD 644
            ..|.:|||||||||||||.|.||.||.||:|.|.|.|.:.:|||.|.:|..|||.|.|:|||.||
  Rat   713 YHCVKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCPLLFNPRQLDYDKDEVGDRCD 777

  Fly   645 NCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLP 709
            ||...:|..|:|||.:|.||.|..|||.|.:.|..||||.:.|..|.|.|.|||||.|||||.:.
  Rat   778 NCPYVHNQAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMH 842

  Fly   710 NPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPN 774
            ||||.|:|.|.|||.|..:.|.||||..|:.||||.:|||:|.|.|.||.||.||.|.|.||:|:
  Rat   843 NPDQMDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPD 907

  Fly   775 YKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGL 839
            .:|||.|..||.|:|.:.:|:||.|:||.|.|.||:..|.||.|:.|..||||..|.:||||||.
  Rat   908 DRDNCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGT 972

  Fly   840 SQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKY 904
            :|.|||||:...|.|:|||.|||||:|||.|.||.|||.||||:|.|.|||||||||.||||.::
  Rat   973 TQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRF 1037

  Fly   905 YVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNI 969
            |||.||:.||||||.:|..|....|:.:|:||||.|.|..:||:|||.|||:|:.|.||.|||||
  Rat  1038 YVVMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNI 1102

  Fly   970 AWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQY 1034
            .||:.|:|||.|:|||..|.:|:.:|||.:::.|||.::|.|..|||||:|.|||.|:.:|:|:|
  Rat  1103 GWKDYTAYRWHLIHRPKTGYMRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKY 1167

  Fly  1035 KCNN 1038
            :|.:
  Rat  1168 ECRD 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	6/35 (17%)
		TSP3 repeat_1C	563..595	CDD:275367	17/34 (50%)
		TSP3 repeat_short	632..654	CDD:275365	12/21 (57%)
		TSP_3	656..690	CDD:280556	17/33 (52%)
		TSP3 repeat_long	656..690	CDD:275366	17/33 (52%)
		TSP3 repeat_short	691..713	CDD:275366	14/21 (67%)
		TSP3 repeat_long	714..751	CDD:275365	20/36 (56%)
		TSP_3	715..751	CDD:280556	20/35 (57%)
		TSP3 repeat_short	752..787	CDD:275366	19/34 (56%)
		TSP_3	789..822	CDD:280556	15/32 (47%)
		TSP_C	841..1038	CDD:283408	116/196 (59%)
		coiled coil	245..286	CDD:293927	11/72 (15%)
		TSPcc_insect	245..286	CDD:293927	11/72 (15%)
		EGF_CA	343..377	CDD:214542	10/95 (11%)
		EGF_CA	421..457	CDD:238011	15/39 (38%)
Thbs2	NP_001162609.1	TSPN	22..213	CDD:214560	24/136 (18%)
		VWC	320..374	CDD:278520	16/60 (27%)
		TSP_1	385..430	CDD:278517	8/44 (18%)
		TSP1	440..492	CDD:214559	5/51 (10%)
		TSP1	497..549	CDD:214559	5/51 (10%)
		EGF_3	652..691	CDD:289699	15/79 (19%)
		TSP3 repeat_1C	693..728	CDD:275367	17/34 (50%)
		TSP3 repeat_long	729..764	CDD:275366	18/34 (53%)
		TSP3 repeat_short	765..787	CDD:275365	12/21 (57%)
		TSP_3	789..823	CDD:280556	17/33 (52%)
		TSP3 repeat_long	789..823	CDD:275366	17/33 (52%)
		TSP3 repeat_short	824..846	CDD:275366	14/21 (67%)
		TSP3 repeat_long	847..884	CDD:275365	20/36 (56%)
		TSP_3	848..884	CDD:280556	20/35 (57%)
		TSP3 repeat_short	885..920	CDD:275366	19/34 (56%)
		TSP_3	922..951	CDD:280556	14/28 (50%)
		TSP_C	974..1171	CDD:283408	116/196 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMRF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	1	1.100	-	-	O	PTHR10199
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750