DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tsp and thbs3a

DIOPT Version :10

Sequence 1:NP_523495.2 Gene:Tsp / 33941 FlyBaseID:FBgn0031850 Length:1060 Species:Drosophila melanogaster
Sequence 2:NP_775332.2 Gene:thbs3a / 252849 ZFINID:ZDB-GENE-020708-3 Length:962 Species:Danio rerio


Alignment Length:1091 Identity:418/1091 - (38%)
Similarity:562/1091 - (51%) Gaps:215/1091 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LIGLTALALTFVDVASLSLDPVASAELEQFIRKGDVVISTRHIRPR-------------RKLHIS 59
            ::||..:..|...|..|||.....:::        .|:||..:.|:             .|.::.
Zfish    34 VLGLEDVKQTVAAVEKLSLALKTLSDV--------YVMSTFRLPPKLGGVLLGLYNKQDNKKYLE 90

  Fly    60 IEALFMIDFPMLKHKMSFFLDRKQQRVTLDISANGATESRNFEIPNINETSTIRSLALQFSKNR- 123
            :..:..|:..::::                :..:|...:.|.:.||:.: ...:||.|:....| 
Zfish    91 VAIMSKINKVLVRY----------------VREDGKLHTVNMQSPNVAD-GRPQSLILRVGGLRR 138

  Fly   124 ----ITLHVDCKASTHHDIDMNLAKLYTQMDDPVIKLFRERKYPLHFDGDMEHSLQRANCQKGNH 184
                :.|:|:|:.:..           .|...|::.|.|:.:.           ::..|..|...
Zfish   139 EYLSLELYVNCRLADS-----------AQRLPPLVDLPRDAEL-----------VEIRNGHKAYA 181

  Fly   185 R-RGNRRMLRNKITEREKNKKRDVRGWYEPTIAREGVVDHRHQEVPTD-----------VERGDI 237
            | :|:...|           |..:.|    |:|:.|.:        ||           :..|::
Zfish   182 RMQGSMDTL-----------KLALGG----TVAQAGAL--------TDCPFQGDASSYNIVNGEV 223

  Fly   238 PVLNGDCEDALARSLSDLLALVKLLREDVAHQRQEIAYLRMLLENCAGC--KNPLTTDNQLRIEP 300
            ..:.||...||...|.....::..||||:..|.:|::.:|..:..|..|  ..|     :.|.:|
Zfish   224 NSILGDHTKALIGQLIIFNQILGELREDIREQVKEMSLVRNAILECQMCGFHEP-----RSRCQP 283

  Fly   301 DCRSANPCYPGVECLDSAAGPRCGHCPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDS 365
                 |||:.||.|:::..                             |||.:|           
Zfish   284 -----NPCFKGVSCMETFE-----------------------------YPGYRC----------- 303

  Fly   366 CPAGYEGDGRTCSLRNPCLDTPCPSGAQCLQVGYPPYFHCISCPMGHEVNGTSCRDMNECLLYDP 430
                                .|||.|    ..|                |||.|:|::||....|
Zfish   304 --------------------GPCPDG----MTG----------------NGTHCQDIDECSEAQP 328

  Fly   431 CDELATCTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCI 495
            |.....|.|.:.||.|..||.|..|....|...:|  ....||.|.|:|||......|..:|.||
Zfish   329 CYTPGACVNTARGFTCESCPPGMWGPPLSGVGVEY--AKSHRQECSDIDECVDLANACTPNSVCI 391

  Fly   496 NEIGSYRC-QCHEGYVTNGTYSCLDR---SSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAG 556
            |.|||:|| ||..|||.|.|..|..|   ||:...|    ||.||.|:...|....|.|||||||
Zfish   392 NIIGSFRCGQCKTGYVGNQTAGCFPRKSCSSLSFNP----CDTNAHCVMQRNGDVSCACNVGWAG 452

  Fly   557 NGLICGRDTDVDGWPDQAIGCPE--LRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNS 619
            ||..||:|||:||:||:::.|.:  ..|::|||...|||||||||.||.||.||:|||||.::|.
Zfish   453 NGHTCGKDTDIDGYPDRSLPCMDNHKHCRQDNCVYTPNSGQEDADNDGIGDQCDEDADGDGIKNV 517

  Fly   620 QDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPL 684
            :|||.|..|.:|.:||.|..||.||||....|..|.|||.:|.||.||.|||.|.|.|.|||||.
Zfish   518 EDNCRLVSNKDQQNSDTDSFGDACDNCPTVPNIDQKDTDSNGEGDACDDDIDGDGIQNVLDNCPK 582

  Fly   685 LPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNS 749
            :|||.|:|.|.||||||||:||.:.||.|.|.|.|.|||.|..:.|.|.||..::.||||.:.||
Zfish   583 VPNPMQTDRDRDGVGDACDSCPEISNPMQTDVDNDLVGDVCDTNQDTDGDGHQDTRDNCPDIPNS 647

  Fly   750 DQLDTDGDGTGDECDDDMDGDGIPNY-------KDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDG 807
            .|||:|.||.||:||:|.|.||||:.       .|||.|..||.|.|.:.||.||.||:|.|.|.
Zfish   648 SQLDSDNDGIGDDCDEDDDNDGIPDNHAINGIGPDNCRLISNPNQKDSDSNGVGDVCENDFDNDS 712

  Fly   808 VPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAF 872
            |.:.:|.||.::.:..||||..||:.|||:|.:|.||||||...|.|||||:|||||||||..||
Zfish   713 VMDLVDVCPESAEVTLTDFRAYQTVILDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAF 777

  Fly   873 GGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNS 937
            .||||:|||::|..||||||||:|.||.|..:|||.||:..||||:..||.|.|.||:|:|.|.|
Zfish   778 NGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQSIPFRAMAEPGLQLKAVKS 842

  Fly   938 TEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIF 1002
            ..|||..:||:|||.|:||||.:||||||:|:.|.::|||||.|.|||.:|.||::::||:.::.
Zfish   843 RTGPGEFLRNALWHAGDTDGEVKLLWKDPRNVGWLDKTSYRWQLSHRPQVGYIRVKLYEGSEMVA 907

  Fly  1003 DSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCNNRVKPLIYNDLSDYLK 1053
            ||..|.|::::|||||||||||..||||||:|:||:.|.    .|.|.:.|
Zfish   908 DSDVVIDTSMRGGRLGVFCFSQENIIWSNLRYRCNDTVP----EDFSSHRK 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TspNP_523495.2 coiled coil 245..286 CDD:293927 11/40 (28%)
TSPcc_insect 245..286 CDD:293927 11/40 (28%)
EGF_CA 421..457 CDD:238011 14/35 (40%)
EGF_CA 477..508 CDD:429571 16/31 (52%)
TSP3 repeat_1C 563..595 CDD:275367 15/33 (45%)
TSP3 repeat_short 632..654 CDD:275365 10/21 (48%)
TSP_3 656..690 CDD:367074 22/33 (67%)
TSP3 repeat_long 656..690 CDD:275366 22/33 (67%)
TSP3 repeat_short 691..713 CDD:275366 14/21 (67%)
TSP_3 714..751 CDD:367074 17/36 (47%)
TSP3 repeat_long 714..751 CDD:275365 17/36 (47%)
TSP3 repeat_short 752..787 CDD:275366 21/41 (51%)
TSP_3 789..822 CDD:367074 14/32 (44%)
TSP_C 841..1037 CDD:461725 120/195 (62%)
thbs3aNP_775332.2 LamG <58..196 CDD:473984 27/195 (14%)
coiled coil 230..272 CDD:293925 11/41 (27%)
TSP-3cc 230..272 CDD:293925 11/41 (27%)
EGF_CA 319..354 CDD:238011 13/34 (38%)
EGF_CA 373..405 CDD:429571 16/31 (52%)
EGF_3 426..457 CDD:463759 17/34 (50%)
TSP type-3 1 459..493 15/33 (45%)
MSCRAMM_ClfA <460..698 CDD:468110 129/237 (54%)
TSP type-3 2 494..529 21/34 (62%)
TSP_3 494..529 CDD:367074 21/34 (62%)
TSP3 repeat_long 494..529 CDD:275366 21/34 (62%)
TSP type-3 3 530..552 10/21 (48%)
TSP3 repeat_short 530..552 CDD:275366 10/21 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..704 85/155 (55%)
TSP_3 553..588 CDD:367074 22/34 (65%)
TSP3 repeat_long 553..588 CDD:275366 22/34 (65%)
TSP3 repeat_short 589..611 CDD:275365 14/21 (67%)
TSP_3 612..649 CDD:367074 17/36 (47%)
TSP3 repeat_long 612..649 CDD:275365 17/36 (47%)
TSP3 repeat_short 650..692 CDD:275366 21/41 (51%)
TSP type-3 8 693..728 14/34 (41%)
TSP_3 693..727 CDD:367074 14/33 (42%)
TSP_C 746..943 CDD:461725 121/196 (62%)

Return to query results.
Submit another query.