DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsp and Thbs2

DIOPT Version :9

Sequence 1:NP_001137802.1 Gene:Tsp / 33941 FlyBaseID:FBgn0031850 Length:1060 Species:Drosophila melanogaster
Sequence 2:NP_035711.2 Gene:Thbs2 / 21826 MGIID:98738 Length:1172 Species:Mus musculus


Alignment Length:1254 Identity:429/1254 - (34%)
Similarity:578/1254 - (46%) Gaps:299/1254 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNWTRVLL---IGLTALALTFVDVASLSLDPVASAE-----LEQFIRKGDVVISTRHIRPRRKLH 57
            |.|...||   ||..|.|...|...|..|..:::..     .:||......|.:.|.:|......
Mouse     1 MLWALALLALGIGPRASAGDHVKDTSFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPP 65

  Fly    58 ISIEALFMIDFPMLKHKMSFFL------DRKQQRVTLDISANGATESRNFEIPNINETSTI---- 112
            ::.:.|..| ..:.:.|..|||      ||| .|.||.:.....|..|.|||.:.....|:    
Mouse    66 VNTDDLNRI-VKLARRKEGFFLTAQLKQDRK-SRGTLLVLEGPGTSQRQFEIVSNGPGDTLDLNY 128

  Fly   113 ---------------------RSLALQFSKNRITLHVDC--------KASTHHDIDMNLAKLYTQ 148
                                 :::.:|.:.:..:|:|.|        :...:..::::.:::|..
Mouse   129 WVEGNQHTNFLEDVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEPFYEQLEVDRSRMYVA 193

  Fly   149 MDDPVIKLFRERKYPLH--FDGDMEHSLQRANCQKGNHRRGNRRMLRNKITEREKNKKRDVRGWY 211
            ........||.....:|  |...:|..|.:..||   |.:|           .|.|         
Mouse   194 KGASRESHFRGLLQNVHLVFADSVEDILSKKGCQ---HSQG-----------AEVN--------- 235

  Fly   212 EPTIAREGVVDHRHQEVPTD-----VERGDIPVLNGDCEDA--LARSLSDLLALVKLLREDVAHQ 269
              ||:......|....:.||     ||:.. .|....||:.  :...||.|..:|..|.:::...
Mouse   236 --TISEHTETLHLSPHITTDLVVQGVEKAQ-EVCTHSCEELSNMMNELSGLHVMVNQLSKNLERV 297

  Fly   270 RQEIAYL--------------------RMLLEN----------CAGCKNPLTTDNQLRIEPDCRS 304
            ..:..:|                    |:..||          |. ||...|..:|:...| ...
Mouse   298 SSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWVVDSCTTCT-CKKFKTVCHQITCSP-ATC 360

  Fly   305 ANPCYPGVECLDSAAGPRCGH--------------------CPLGFIGDGKSCK--------PGV 341
            |||.:...||.     |.|.|                    |..|....|:||.        |.:
Mouse   361 ANPSFVEGECC-----PSCSHSADSDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSI 420

  Fly   342 ---TCAHHMC-------------YPGVQCHDT------------------VNGAQC--------- 363
               ||:...|             .|...|..|                  :.|..|         
Mouse   421 QTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKP 485

  Fly   364 ---DSCP-------------------AGYEGDGRTCSLRNP------------------------ 382
               |.||                   .|.....|.|:...|                        
Mouse   486 CQRDPCPIDGRWSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCPI 550

  Fly   383 --CLDTPCPSGAQCLQVGYPP-YFHCISCPMGHEVNGTSCRDMNEC-LLYDPC---DELATCTNL 440
              ||..||..||:|  ..:|. .:.|.|||:|...|||.|.|::|| ::.|.|   ::...|.|.
Mouse   551 DGCLSNPCFPGAKC--NSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDICFSTNKAPRCVNT 613

  Fly   441 SPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIGSYRCQC 505
            :|||.|.|||..:.|....|               :.:::.||....|...:.|.::        
Mouse   614 NPGFHCLPCPPRYKGNQPFG---------------VGLEDARTEKQVCEPENPCKDK-------- 655

  Fly   506 HEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNI---RHKCHCNVGWAGNGLICGRDTDV 567
                    |:|               |.:||.|:.:.:.   .:||.|.:|:||:|||||.|:|:
Mouse   656 --------THS---------------CHKNAECIYLGHFSDPMYKCECQIGYAGDGLICGEDSDL 697

  Fly   568 DGWPDQAIGC---PELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNT 629
            ||||:..:.|   ....|.:|||||||||||||.|.||.||.||:|.|.|.|.:.:|||.|.:|.
Mouse   698 DGWPNNNLVCATNATYHCIKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCQLLFNP 762

  Fly   630 EQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVD 694
            .|||.|.|:|||.||||...:||.|:|||.:|.||.|..|||.|.:.|..||||.:.|..|.|.|
Mouse   763 RQLDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTD 827

  Fly   695 NDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGT 759
            .|||||.|||||.:.||||.|:|.|.|||.|..:.|.||||..|:.||||.:|||:|.|.|.||.
Mouse   828 GDGVGDHCDNCPLMHNPDQIDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGK 892

  Fly   760 GDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHT 824
            ||.||.|.|.||:|:.:|||.|..||.|:|.:.:|:||.|:||.|.|.||:..|.||.|:.|..|
Mouse   893 GDACDSDDDNDGVPDDRDNCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITET 957

  Fly   825 DFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDD 889
            |||..|.:||||||.:|.|||||:...|.|:|||.|||||:|||.|.||.|||.||||:|.|.||
Mouse   958 DFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDD 1022

  Fly   890 DYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGN 954
            |||||||.||||.::|||.||:.||||||.:|..|....|:.:|:||||.|.|..:||:|||.||
Mouse  1023 DYAGFVFGYQSSSRFYVVMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGN 1087

  Fly   955 TDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGV 1019
            |:|:.|.||.|||||.||:.|:|||.|:|||..|.:|:.:|||.:::.|||.::|.|..|||||:
Mouse  1088 TEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQVMADSGPIYDQTYAGGRLGL 1152

  Fly  1020 FCFSQRMIIWSNLQYKCNN 1038
            |.|||.|:.:|:|:|:|.:
Mouse  1153 FVFSQEMVYFSDLKYECRD 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TspNP_001137802.1 EGF_CA 477..513 CDD:284955 4/35 (11%)
TSP3 repeat_1C 563..595 CDD:275367 17/34 (50%)
TSP3 repeat_short 632..654 CDD:275365 13/21 (62%)
TSP_3 656..690 CDD:280556 17/33 (52%)
TSP3 repeat_long 656..690 CDD:275366 17/33 (52%)
TSP3 repeat_short 691..713 CDD:275366 14/21 (67%)
TSP3 repeat_long 714..751 CDD:275365 20/36 (56%)
TSP_3 715..751 CDD:280556 20/35 (57%)
TSP3 repeat_short 752..787 CDD:275366 19/34 (56%)
TSP_3 789..822 CDD:280556 15/32 (47%)
TSP_C 841..1038 CDD:283408 116/196 (59%)
coiled coil 245..286 CDD:293927 11/72 (15%)
TSPcc_insect 245..286 CDD:293927 11/72 (15%)
EGF_CA 343..377 CDD:214542 12/95 (13%)
EGF_CA 421..457 CDD:238011 15/39 (38%)
Thbs2NP_035711.2 Heparin-binding. /evidence=ECO:0000255 19..232 41/228 (18%)
TSPN 21..213 CDD:214560 34/193 (18%)
VWC 320..374 CDD:278520 15/60 (25%)
TSP_1 385..430 CDD:278517 8/44 (18%)
TSP1 440..492 CDD:214559 6/51 (12%)
TSP1 497..549 CDD:214559 4/51 (8%)
EGF_3 652..691 CDD:289699 15/69 (22%)
TSP type-3 1 693..728 17/34 (50%)
TSP3 repeat_1C 693..728 CDD:275367 17/34 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 727..752 15/24 (63%)
TSP type-3 2 729..764 18/34 (53%)
TSP3 repeat_long 729..764 CDD:275366 18/34 (53%)
TSP type-3 3 765..787 13/21 (62%)
TSP3 repeat_short 765..787 CDD:275365 13/21 (62%)
TSP type-3 4 788..823 17/34 (50%)
TSP_3 789..823 CDD:280556 17/33 (52%)
TSP3 repeat_long 789..823 CDD:275366 17/33 (52%)
TSP type-3 5 824..846 14/21 (67%)
TSP3 repeat_short 824..846 CDD:275366 14/21 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..938 49/91 (54%)
TSP3 repeat_long 847..884 CDD:275365 20/36 (56%)
TSP_3 848..884 CDD:280556 20/35 (57%)
TSP3 repeat_short 885..920 CDD:275366 19/34 (56%)
TSP type-3 8 921..956 16/34 (47%)
TSP_3 922..951 CDD:280556 14/28 (50%)
Cell attachment site. /evidence=ECO:0000255 928..930 0/1 (0%)
TSP_C 974..1171 CDD:283408 116/196 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847608
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2CMRF
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D120983at2759
OrthoFinder 1 1.000 - - FOG0001167
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101187
Panther 1 1.100 - - O PTHR10199
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.750

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