Protein Alignment Tsp and thbs1a

DIOPT Version :9

• Sequence 1: NP_001137802.1
• Gene: Tsp / 33941
• FlyBaseID: FBgn0031850
• Length: 1060
• Species: Drosophila melanogaster
• Sequence 2: XP_002667003.4
• Gene: thbs1a / 100332237
• ZFINID: ZDB-GENE-120402-2
• Length: 965
• Species: Danio rerio
• Alignment Length: 1043
• Identity: 375/1043 - (35%)
• Similarity: 484/1043 - (46%)
• Gaps: 259/1043 - (24%)

  Fly   166 FDGDMEHSLQRANCQKGN----------HRRGNRRMLRNKITEREKNKKRDVRGWYEPTIAREGV 220
            |...::..|:...||..:          |..|:...:|...|..:....:||.|:
Zfish    11 FGTTVDAILRNKGCQSSSFIPDVLTLEKHVNGSSPAIRTDYTGHKTKDLQDVCGF---------- 65

  Fly   221 VDHRHQEVPTDVERGDIPVLNGDCED--ALARSLSDLLALVKLLREDV---------------AH 268
                                  .|:|  ::.:.|..|..:||.|..|:               .|
Zfish    66 ----------------------SCDDLTSMFKELKGLGVVVKQLSNDLRQVTADNNLIKTQIKVH 108

  Fly   269 Q----RQEIAYL---RMLLENCAGCKNPLTTDNQLRIEPDCRS--------ANPCYPGVECLDSA 318
            :    ...|.|.   ...:::|..|    |..|...:   ||.        ||...|..||.
Zfish   109 EGVCLHNRIVYQDRDEWTVDSCTHC----TCQNSATV---CREISCPLMPCANATVPEGECC--- 163

  Fly   319 AGPRCG---------------------HCPLGFIGDGKSCK------PGVTCAHHMCYP------ 350
              ||||                     .|..|....|:||.      .|.:.....||.
Zfish   164 --PRCGTPSDAGIDGWSPWSEWTMCSVSCGRGIQQRGRSCDRINSNCDGTSVQTRDCYTQECDKR 226

  Fly   351 ----------------GVQCHDTV--------------NGAQC------------DSCP------ 367
                            .|.|.|.|              .|..|            |.||
Zfish   227 FKQDGSWSHWSPWSSCSVSCGDGVITRIRLCNSPTPQMGGRDCAGEGRETEPCQQDPCPVNGGWG 291

  Fly   368 -------------AGYEGDGRTCSLRNP--------------------------CLDTPCPSGAQ 393
                         .|.:...|.|:...|                          ||..||.|||:
Zfish   292 PWSLWDSCSVSCGGGLQRRHRLCNSPAPKYGGKDCVGDSKAARMCNAQSCPVDGCLSNPCFSGAK 356

  Fly   394 CLQVGYPP-YFHCISCPMGHEVNGTSCRDMNECL-LYDPC---DELATCTNLSPGFQCSPCPVGF 453
            |  ..:|. .:.|..||.|:..:||.|.|::||. :.|.|   :.:..|.|..||:.|.|||..:
Zfish   357 C--NSFPDGSWSCGECPAGYTGDGTHCEDIDECKEVPDACFVLNGVHQCENTEPGYNCLPCPPRY 419

  Fly   454 DGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIGSYRCQCHEGYVTNGTYSCL 518
            .|...:|...:....:  :|.|...:.|..|...|.:::.||             |:  |.:|
Zfish   420 SGQQPYGRGTEQAIAN--KQVCTPRNPCADGSHDCNKNANCI-------------YL--GIFS-- 465

  Fly   519 DRSSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQAIGCPE---L 580
                                    :|..:|.|..|:||||.|||.|.|:||||:..:.|.|   .
Zfish   466 ------------------------DIMFRCECKPGYAGNGHICGEDPDLDGWPNTDLHCVENATY 506

  Fly   581 RCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCDN 645
            .|::||||.||||||||.|.||.||.||.|.|.|.:.:..|||...:|..|.|.|.|:|||.|||
Zfish   507 HCKKDNCPDLPNSGQEDYDKDGIGDACDHDDDNDGIPDDGDNCPFVFNPRQYDQDRDQVGDRCDN 571

  Fly   646 CVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPN 710
            |:...|..|.|||.:|.||.|..|||.|.|.|..||||.:.|..|.|.|.|||||.|||||...|
Zfish   572 CIYDSNTDQTDTDNNGEGDACAIDIDGDGILNEKDNCPYVYNTDQRDTDRDGVGDHCDNCPLEHN 636

  Fly   711 PDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPNY 775
            |||.|.|.|.:||.|..:.|.|:||..|:|||||.:.|::|.|.|.||.||.||.|.|.||||:.
Zfish   637 PDQIDSDSDNIGDKCDSNQDIDEDGHQNNLDNCPYIPNANQADHDKDGKGDVCDHDDDNDGIPDD 701

  Fly   776 KDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGLS 840
            :|||.|..||.|.|.:.:|:||:|:||.|.|.||:..|.||.|..|..||||..|.:||||.|.|
Zfish   702 RDNCRLVFNPDQLDSDGDGRGDACKDDFDDDNVPDIYDVCPENFAISETDFRRFQMVPLDPTGTS 766

  Fly   841 QADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYY 905
            |.||||||...|.|::||:|.|||:|||.|.|..|||.|||:||.|.|||||||||.||||.::|
Zfish   767 QIDPNWVVRHQGKELLQTVNCDPGIAVGFDEFNSVDFSGTFFINTDRDDDYAGFVFGYQSSSRFY 831

  Fly   906 VVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIA 970
            ||.||:.|||||...|..|....|:.||:||||.|||..:||:|||.|:|:|:.|.||.|||||.
Zfish   832 VVMWKQITQTYWSHTPTKAQGYSGLSIKVVNSTTGPGEHLRNALWHTGDTEGQVRTLWHDPKNIG 896

  Fly   971 WKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYK 1035
            ||:.|:|||.|:|||..|.||:.|:||.:::.|||:|:|.|..|||||:|.|||.|:.:|:|:|:
Zfish   897 WKDFTAYRWHLIHRPKTGHIRVIMYEGKKVMADSGSVYDKTYAGGRLGLFVFSQEMVYFSDLKYE 961

  Fly  1036 CNN 1038
            |.:
Zfish   962 CRD 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	6/35 (17%)
		TSP3 repeat_1C	563..595	CDD:275367	17/34 (50%)
		TSP3 repeat_short	632..654	CDD:275365	11/21 (52%)
		TSP_3	656..690	CDD:280556	18/33 (55%)
		TSP3 repeat_long	656..690	CDD:275366	18/33 (55%)
		TSP3 repeat_short	691..713	CDD:275366	14/21 (67%)
		TSP3 repeat_long	714..751	CDD:275365	17/36 (47%)
		TSP_3	715..751	CDD:280556	17/35 (49%)
		TSP3 repeat_short	752..787	CDD:275366	20/34 (59%)
		TSP_3	789..822	CDD:280556	15/32 (47%)
		TSP_C	841..1038	CDD:283408	116/196 (59%)
		coiled coil	245..286	CDD:293927	11/64 (17%)
		TSPcc_insect	245..286	CDD:293927	11/64 (17%)
		EGF_CA	343..377	CDD:214542	13/100 (13%)
		EGF_CA	421..457	CDD:238011	14/39 (36%)
thbs1a	XP_002667003.4	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	1	1.100	-	-	O	PTHR10199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840