DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp and comp

DIOPT Version :9

Sequence 1:	NP_001137802.1	Gene:	Tsp / 33941	FlyBaseID:	FBgn0031850	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001313279.1	Gene:	comp / 100318854	ZFINID:	ZDB-GENE-060606-1	Length:	749	Species:	Danio rerio

Alignment Length:	814	Identity:	363/814 - (44%)
Similarity:	470/814 - (57%)	Gaps:	113/814 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 DLLALVKLLREDVAHQRQEIAYLRMLLENCAGC-KNPLTTDNQLRIEPDCRSANPCYPGVECLDS 317
            :|..:.:||::.:    |||.:|:..:..|..| ..|..      ::|.| ..|||:.||||:
Zfish    39 ELAEIKELLKQQI----QEIVFLKNTVMECEACGMRPAD------LQPSC-DPNPCHSGVECI-- 90

  Fly   318 AAGPRCGHCPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDSCPAGYEGDGRTCSLRNP 382
                                                  .|.||.:|.:||||..||
Zfish    91 --------------------------------------VTPNGIKCGACPAGMTGD--------- 108

  Fly   383 CLDTPCPSGAQCLQVGYPPYFHCISCPMGHEVNGTSCRDMNECLLYDPCDELATCTNLSPGFQCS 447
                                             ||.|.|::||.:. ||.....|.|.||||:|.
Zfish   109 ---------------------------------GTHCEDVDECTVI-PCHMGVRCINTSPGFRCG 139

  Fly   448 PCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIGSYRC-QCHEGYVT 511
            |||.|:.|....|....|.|.:  :|.|.|::||......|.|:|.|||..||:|| :|:.|:|.
Zfish   140 PCPAGYTGQQVQGVGIPYASAN--KQVCTDINECANSNGGCVENSNCINTPGSFRCGRCNAGFVG 202

  Fly   512 NGTYSC-LDRSSVFMCPDG--TVCDRNAVCLRMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQ 573
            :....| .:|:    |.:|  ..|..:|.|:...:.:.:|.|.|||||||.:||.|||:||:||:
Zfish   203 DQVKGCKAERT----CGNGQPNPCHASAECIVHRDGQIECACGVGWAGNGYLCGTDTDIDGFPDE 263

  Fly   574 AIGCPELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDK 638
            .:.|.|..|.:|||..:|||||||||.|..||.||||||||.:.|.:|||.|..|..|.::|.|.
Zfish   264 KLECVERNCAKDNCLTVPNSGQEDADKDNIGDACDDDADGDGILNIEDNCVLVPNVNQKNTDQDD 328

  Fly   639 VGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACD 703
            .||.||||.|..|..|.|||.||.|||||.|||.|.|.|..|||..:||..|.|.|.|.||||||
Zfish   329 YGDACDNCRLVKNNDQKDTDADGQGDECDDDIDGDGIKNDNDNCKKVPNRDQKDRDGDNVGDACD 393

  Fly   704 NCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMD 768
            :||.:.||||.|.|.|.:||.|..:.|.|.||..:|.||||.|.||.|||||.||.|||||||.|
Zfish   394 SCPYIRNPDQTDVDNDLIGDPCDTNKDSDGDGHQDSRDNCPAVINSSQLDTDKDGIGDECDDDDD 458

  Fly   769 GDGIPNY----KDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTL 829
            .||||:.    .|||.|..||.|:|.:.:|.|:.||:|.|.|...:.:|.||.|:.:..|||||.
Zfish   459 NDGIPDLLPPGPDNCRLVPNPLQEDIDGDGIGNVCENDFDNDTFSDIIDVCPENAEVTLTDFRTY 523

  Fly   830 QTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGF 894
            ||:.|||:|.:|.||||||...|.|||||:|||||||||..||.||||:|||::|.:||||||||
Zfish   524 QTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTETDDDYAGF 588

  Fly   895 VFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEA 959
            :|.||.|..:|||.||:..|.||:..||.|.|.||||:|.|.|..|||..:||||||.|::..:.
Zfish   589 IFGYQDSSSFYVVMWKQVEQIYWQANPFRAVAEPGIQLKAVKSDTGPGENLRNSLWHTGDSTNQV 653

  Fly   960 RLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQ 1024
            :|||||.:|:.||::|||||.|.|||..|.||::.:||.:::.|:|.:.|:|::|||||||||||
Zfish   654 KLLWKDSRNVGWKDKTSYRWFLQHRPQEGYIRVRFYEGQQMVADTGVIIDATMRGGRLGVFCFSQ 718

  Fly  1025 RMIIWSNLQYKCNNRVKPLIYNDLSDYLKTKVEL 1058
            ..|||:||:|:||:.:.    .|...:...:::|
Zfish   719 ENIIWANLRYRCNDTIP----EDFETFRTQQIQL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp	NP_001137802.1	EGF_CA	477..513	CDD:284955	16/36 (44%)
		TSP3 repeat_1C	563..595	CDD:275367	16/31 (52%)
		TSP3 repeat_short	632..654	CDD:275365	10/21 (48%)
		TSP_3	656..690	CDD:280556	21/33 (64%)
		TSP3 repeat_long	656..690	CDD:275366	21/33 (64%)
		TSP3 repeat_short	691..713	CDD:275366	13/21 (62%)
		TSP3 repeat_long	714..751	CDD:275365	18/36 (50%)
		TSP_3	715..751	CDD:280556	18/35 (51%)
		TSP3 repeat_short	752..787	CDD:275366	24/38 (63%)
		TSP_3	789..822	CDD:280556	12/32 (38%)
		TSP_C	841..1038	CDD:283408	117/196 (60%)
		coiled coil	245..286	CDD:293927	8/31 (26%)
		TSPcc_insect	245..286	CDD:293927	8/31 (26%)
		EGF_CA	343..377	CDD:214542	10/33 (30%)
		EGF_CA	421..457	CDD:238011	17/35 (49%)
comp	NP_001313279.1	coiled coil	28..67	CDD:293924	8/31 (26%)
		TSP-5cc	28..67	CDD:293924	8/31 (26%)
		EGF_CA	114..148	CDD:238011	16/34 (47%)
		EGF_CA	167..203	CDD:238011	16/35 (46%)
		TSP3 repeat_1C	254..285	CDD:275367	16/30 (53%)
		TSP3 repeat_long	286..321	CDD:275366	21/34 (62%)
		TSP3 repeat_short	322..344	CDD:275365	10/21 (48%)
		TSP3 repeat_long	345..380	CDD:275366	21/34 (62%)
		TSP3 repeat_short	381..403	CDD:275365	13/21 (62%)
		TSP3 repeat_long	404..441	CDD:275365	18/36 (50%)
		TSP_3	405..441	CDD:280556	18/35 (51%)
		TSP3 repeat_short	442..481	CDD:275366	24/38 (63%)
		TSP3 repeat_long	482..513	CDD:275365	11/30 (37%)
		TSP_3	483..516	CDD:280556	12/32 (38%)
		TSP_C	535..732	CDD:283408	117/196 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592962
Domainoid	1	1.000	285	1.000	Domainoid score	I1574
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74
Inparanoid	1	1.050	738	1.000	Inparanoid score	I580
OMA	1	1.010	-	-		QHG49685
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	1	1.000	-	-		otm26215
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810