Protein Alignment Nhe3 and NHA1

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_013239.1
• Gene: NHA1 / 850829
• SGDID: S000004128
• Length: 985
• Species: Saccharomyces cerevisiae
• Alignment Length: 619
• Identity: 123/619 - (19%)
• Similarity: 212/619 - (34%)
• Gaps: 184/619 - (29%)

  Fly    64 WLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPP 128
            ::.|:.:|.|:|||||                             |....||. |:...|
Yeast    38 YIGESTVAGIFGLIVG-----------------------------PVCLNWFN-PLKWGN----- 67

  Fly   129 EGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFA 193
                              .:.|.|:.|       .|:|...||.....|.:||..::..::....
Yeast    68 ------------------SDSITLEIT-------RIVLCLQIFAVAVELPRKYMLKHWVSVTMLL 107

  Fly   194 IVGTTLSAFLIGGFMYGCVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFND---LRVDVN 255
            :...|....:||.|::        .|.....|..||...|.|:.|||:...::.:.   .||..:
Yeast   108 LPVMTAGWLIIGLFVW--------ILIPGLNFSASLLISACITATDPILAQSVVSGKFAQRVPGH 164

  Fly   256 LYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLL-SLMIGAAMGC 319
            |..|:..||..||.:|........|...|..|..|.        :.|:..:.:| ..:.|..:||
Yeast   165 LRNLLSAESGCNDGMAFPFLFLSMNLILHPGNGREI--------VKDWICVTILYECLFGCLLGC 221

  Fly   320 LTA----LMTKFTRVRDFPLLES--ALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNL 378
            ...    :..:|...::....||  |.:|:::   |:.|....:.||..:|......|.:.::..
Yeast   222 FIGYVGRITIRFAEKKNIIDRESFLAFYVVLA---FMCAGFGSILGVDDLLVSFAAGATFAWDGW 283

  Fly   379 SEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWL 443
            .....|.: .:..:::.|.....|.|.|.   ..|...|:.|.|.|           ||:.|..|
Yeast   284 FSQKTQES-NVSTVIDLLLNYAYFIYFGA---IIPWSQFNNGEIGT-----------NVWRLIIL 333

  Fly   444 ----LNIKRKPKIS---------TNFQHMLFFA-----GLRGAMSFALAIR----NTVSDE---- 482
                :.::|.|.:.         .:::..||..     |: ||:..|:..|    :|.|||
Yeast   334 SIVVIFLRRIPAVMILRPLIPDIKSWREALFVGHFGPIGV-GAIFAAILARGELESTFSDEPTPL 397

  Fly   483 ---------RQTMLTA-----TSLIVIFTVVIQGGAANFL-----LNWLKIPVGVDDETEQLNN- 527
                     :...|.|     |...::.::::.|.:...:     ||.:.:.......|...:|
Yeast   398 NVVPSKEESKHWQLIACIWPITCFFIVTSIIVHGSSVAIITLGRHLNTITLTKTFTTHTTNGDNG 462

  Fly   528 -----------------YQVHSVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTD-TNLDT 574
                             :.:|.:...|..|   ..:|..:  ||||    :..|:||.| ..|:.
Yeast   463 KSSWMQRLPSLDKAGRSFSLHRMDTQMTLS---GDEGEAE--EGGG----RKGLAGGEDEEGLNN 518

  Fly   575 PVDG---TNGSLGGASGG---RRRNSHEKAILAR 602
            ...|   |:|.....:||   ||:.|.::..|.|
Yeast   519 DQIGSVATSGIPARPAGGMPRRRKLSRKEKRLNR 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	85/448 (19%)
NHA1	NP_013239.1	c_cpa1	2..923	CDD:273295	123/619 (20%)