Protein Alignment Nhe3 and Slc9a8

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_036018592.1
• Gene: Slc9a8 / 77031
• MGIID: 1924281
• Length: 604
• Species: Mus musculus
• Alignment Length: 543
• Identity: 171/543 - (31%)
• Similarity: 285/543 - (52%)
• Gaps: 96/543 - (17%)

  Fly    36 QSLDLLVF--VFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEP 98
            ||..:.:|  :.:||:.::.:.|...:|:.:|.|:...|..|:::||:|:
Mouse    51 QSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIK--------------- 100

  Fly    99 QGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFN 163
                         .:.|:...|.                        .|.|:     |.|.:||.
Mouse   101 -------------VIEFKKLANW------------------------KEEEM-----FRPNMFFL 123

  Fly   164 IILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLS-----SSF 223
            ::||||||.:||||.|..||:|:|:|..||:.||.:|||::||.:|        :|.     |..
Mouse   124 LLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIY--------FLGQADVISKL 180

  Fly   224 TFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNY-GEHYSN 287
            ...||..||:|||..||:..:||||.|.||..|..||.|||:|||||:|||:...:.. .:|.|:
Mouse   181 NMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKHMSD 245

  Fly   288 TGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLA 352
            ...::|  |.::|..|..:|..|..:|...|.::||:.|...:|..|.||..:.::.:|..:.||
Mouse   246 VSGWQT--FSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLA 308

  Fly   353 EATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHF 417
            |...|:|::|:||.||..:|||::|||..::...:|....:.||.|..:|:::|:|:|:|| |.|
Mouse   309 EGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKF 372

  Fly   418 DAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVS-- 480
            :..|:|...:....|||||::|||:|||..|..||:.....:::|:|||||:.:||::...:.
Mouse   373 EISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPM 437

  Fly   481 DERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDD------ETEQLNNYQVHSVYNSMDN 539
            ::||.:.|.|.:||:||:::.||:...|:..    |.::|      ..:.:|..:...:.|::::
Mouse   438 EKRQLIGTTTIVIVLFTILLLGGSTMPLIRL----VDIEDARARRRSKKDVNLSKTEKMGNAIES 498

  Fly   540 SH--PQTSDGY------LQDVEG 554
            .|  ..|.:.|      .||::|
Mouse   499 EHLSELTEEEYEAHYIRQQDLKG 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	146/389 (38%)
Slc9a8	XP_036018592.1	Na_H_Exchanger	59..>483	CDD:470090	160/495 (32%)