DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nhe3 and SLC9A5

DIOPT Version :10

Sequence 1:NP_723202.2 Gene:Nhe3 / 33939 FlyBaseID:FBgn0028703 Length:711 Species:Drosophila melanogaster
Sequence 2:NP_004585.1 Gene:SLC9A5 / 6553 HGNCID:11078 Length:896 Species:Homo sapiens


Alignment Length:590 Identity:162/590 - (27%)
Similarity:251/590 - (42%) Gaps:125/590 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 HRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVE 97
            |.:::..|:....|:|.....::.......|.:.|:.|.::.||::|.|:......|   ..|:|
Human    42 HEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKA---EYQLE 103

  Fly    98 PQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFF 162
            |                         ||                                   ||
Human   104 P-------------------------GT-----------------------------------FF 108

  Fly   163 NIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVK---LMPKYLSSSFT 224
            ..:||||:..:||.:..:.||.|||||||:|:|||..:||..|..::|..:   :.|:..:.   
Human   109 LFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAG--- 170

  Fly   225 FLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTG 289
            .||.|.||:|||..||:.:||:|.::.|:..|:.:|.|||:|||||.:||.....::.|  ..:.
Human   171 LLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVE--MGSA 233

  Fly   290 EFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFT-RVRDFPLLESALFVLMSYSTFLLAE 353
            ..:.|.:|:.::..|.:.|....:|.....|.||.|:|| |||   ::|..|..|::|:.:|.||
Human   234 NVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVR---IIEPLLVFLLAYAAYLTAE 295

  Fly   354 ATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFD 418
            ...|:.::||..||:....|...|:|..||...|...:.|...||..||..:|:|.....|..:|
Human   296 MASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWD 360

  Fly   419 AGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAI--RNTVSD 481
            :|.::...|.....||:.|...:|:||..|...:....|.::.:.|||||::|||.|  ..|...
Human   361 SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVP 425

  Fly   482 ERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVYNSMDNSHPQTSD 546
            .:...:..|.::|.|||::||.....|:.|||:... :.....||           ...|..|.|
Human   426 AKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRS-EHHKPTLN-----------QELHEHTFD 478

  Fly   547 GYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKY 611
            ..|..||                     .|.|.:    |....|.|           |..||.||
Human   479 HILAAVE---------------------DVVGHH----GYHYWRDR-----------WEQFDKKY 507

  Fly   612 MKPLL 616
            :..||
Human   508 LSQLL 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nhe3NP_723202.2 Na_H_Exchanger 155..>531 CDD:470090 127/381 (33%)
SLC9A5NP_004585.1 Na_H_Exchanger 41..630 CDD:470090 162/590 (27%)
Required for interaction with ARRB2. /evidence=ECO:0000269|PubMed:21296876 576..721
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..686
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..720
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..864
Blue background indicates that the domain is not in the aligned region.

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