Protein Alignment Nhe3 and SLC9A1

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_003038.2
• Gene: SLC9A1 / 6548
• HGNCID: 11071
• Length: 815
• Species: Homo sapiens
• Alignment Length: 80
• Identity: 20/80 - (25%)
• Similarity: 33/80 - (41%)
• Gaps: 24/80 - (30%)

  Fly    82 EYNPSRF---HGVVMRIRDPRCTALVFRSGKVICTG---AKNEQQAHLGLRKFVRIIQKLGFDVK 140
            ::||..|   :|.:.:..    ..|.|.:||.||.|   |:||.     ...|..::|
Human   407 KFNPEHFLDANGALKKSE----AFLPFSTGKRICLGEGIARNEL-----FLFFTALLQ------- 455

  Fly   141 FLDFKVQNLVATADL 155
              :|.:.:.||..|:
Human   456 --NFSLSSPVAPEDI 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	0/1 (0%)
SLC9A1	NP_003038.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..79
		b_cpa1	95..660	CDD:273294	20/80 (25%)
		Interaction with TESC. /evidence=ECO:0000269|PubMed:30287853	503..545
		PI(4,5)P2-binding region. /evidence=ECO:0000250|UniProtKB:P26431	509..516
		Interaction with CHP2. /evidence=ECO:0000269|PubMed:21392185	515..545
		Confers pH-dependent PI(4,5)P2 binding. /evidence=ECO:0000269|PubMed:27650500	540..545
		PI(4,5)P2-binding region. /evidence=ECO:0000250|UniProtKB:P26431	552..560
		Interaction with CALM1. /evidence=ECO:0000269|PubMed:30287853	633..815
		Interaction with TESC. /evidence=ECO:0000269|PubMed:12809501	633..815
		Interaction with PPP3CA. /evidence=ECO:0000269|PubMed:31375679	684..687
		Interaction with PPP3CA. /evidence=ECO:0000269|PubMed:31375679	715..720
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..815