Protein Alignment Nhe3 and slc9a8

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001008586.1
• Gene: slc9a8 / 494043
• ZFINID: ZDB-GENE-041212-7
• Length: 637
• Species: Danio rerio
• Alignment Length: 543
• Identity: 175/543 - (32%)
• Similarity: 288/543 - (53%)
• Gaps: 98/543 - (18%)

  Fly    36 QSLDLLVFVFLLALTVLTIWL-----FKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQ 95
            ||..:.:|..||.:.:..|.:     ||.|   :|.|:...|..|:::||.|:.
Zfish   112 QSSGMTIFFSLLVIGICIILVHLLIKFKLH---FLPESVAVVSLGILMGAFIKI----------- 162

  Fly    96 VEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEV 160
            :|.|                                         |:.:..|.|:     |.|.:
Zfish   163 IESQ-----------------------------------------QLANWKEEEM-----FRPNM 181

  Fly   161 FFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMY--GCVKLMPKYLSSSF 223
            ||.::||||||.:||||.|..||:|:|:|..||:.||.:|||::||.:|  |...::.|     .
Zfish   182 FFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFIVGGGIYFLGQADVIYK-----M 241

  Fly   224 TFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNT 288
            |..||..||:|||..||:..:||||.|.||..|..||.|||:|||||:|||:...:.:|....:|
Zfish   242 TMTDSFAFGSLISAVDPVATIAIFNALNVDPVLNMLVFGESILNDAVSIVLTNTAEGFGGSDVST 306

  Fly   289 GEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAE 353
            | :||  |:::|..|..:|..|..:|...|.::|:..|...:|..|.||..:.::.:|..:.|||
Zfish   307 G-WET--FMQALGYFLKMFFGSAALGTLTGPISAISLKHFDLRKTPSLEFGMMIIFAYLPYGLAE 368

  Fly   354 ATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFD 418
            ..:|:|::|:||.||..:|||::|||..::...:|....:.|:.|..:|:::|:|:|:|| |.|:
Zfish   369 GIKLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFMCETCVFAFLGLSIFSFP-HKFE 432

  Fly   419 AGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVS--D 481
            ..|:|...:...:|||||::|||:|||..|..||:.....:::|:|||||:.:||::...:.  :
Zfish   433 LSFVIWCIVLVLVGRAVNIFPLSFLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPIE 497

  Fly   482 ERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETE-------QLNNYQVHSVYNSMDN 539
            :||.:.|.|.:||:||:::.||....|:..:.|     :|::       .:|..:...:.|::::
Zfish   498 KRQLIGTTTIVIVLFTILLMGGGTMPLIRIMDI-----EESQSRRKSKKDINLSKTEKMGNAIES 557

  Fly   540 SH--PQTSDGY------LQDVEG 554
            .|  ..|.:.|      .||::|
Zfish   558 EHLSELTEEEYEAQIYQRQDLKG 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	147/386 (38%)
slc9a8	NP_001008586.1	Na_H_Exchanger	120..>542	CDD:470090	164/495 (33%)