Protein Alignment Nhe3 and Slc9a9

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001258367.1
• Gene: Slc9a9 / 363115
• RGDID: 1560736
• Length: 644
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 309/682 - (45%)
• Similarity: 408/682 - (59%)
• Gaps: 116/682 - (17%)

  Fly    37 SLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGV 101
            :::||.|.|||.||:|||||||:||..:|||||.|::||||:|.|:|||.....:....|...|.
  Rat    21 AVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGK 85

  Fly   102 PTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQV--HDVDE---NEIDLKATFDPEVF 161
            ..:|    |.||.    ||.|:        :.|.|.::.::  |::..   |.|..|.|||||:|
  Rat    86 LLFS----PSTLL----VNITD--------QVYEYKYQREINQHNISPHQGNAILEKMTFDPEIF 134

  Fly   162 FNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLM---PKYLSSSF 223
            ||::||||||:|||||||::||:|||:|||:|.:||.:|..:||..|||.||.|   .:..|..|
  Rat   135 FNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDF 199

  Fly   224 TFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNT 288
            .|.|.|:||:|:|.|||:|:||||::|.||.:||.|:.|||||||||||||:.:|..|... .|.
  Rat   200 HFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENP 263

  Fly   289 GEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAE 353
            ..|:|.||.:|:.:|..||..|..:|:|...:|||:||||::|:||:||:.||.|:|:|.||.||
  Rat   264 NAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAE 328

  Fly   354 ATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFD 418
            |..|||:|||||||:.||||||||||.||:.||||:||.:||||||.||.|:|:::|||..|.|:
  Rat   329 AAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFN 393

  Fly   419 AGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDER 483
            |.||:.||:...:.||.|:||||:|||:.||.||..|||||:.|:|||||::||||||||.|..:
  Rat   394 ALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPK 458

  Fly   484 QTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVD-DET--EQLNNYQVHSVYNSMDNSHPQTS 545
            |.|.|.|.|:|.|||.:.||....:|.||:|.|||| ||:  |:.::.|   ..|.:|....:|
  Rat   459 QMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQ---EANKVDKDMTKT- 519

  Fly   546 DGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTK 610
                                                              |.|.|.|:|..||.|
  Rat   520 --------------------------------------------------ESAQLFRMWYGFDHK 534

  Fly   611 YMKPLLTHSRPTLLETLPVCCNPIARLLTTTQ----QLTQDGSEFRRVDSDSDICIDND------ 665
            |:||:||||.|.|..|||..|.|::||||:.|    ||.:|..|          ||.|.
  Rat   535 YLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVE----------CIVNQDELAMN 589

  Fly   666 ------------TGNGLSQDGSGAAPGVGRRN 685
                        |...|.|..||..  :|:.|
  Rat   590 YQEQSPTSSSPATKLALDQKSSGLT--LGKEN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	218/381 (57%)
Slc9a9	NP_001258367.1	Na_H_Exchanger	12..541	CDD:470090	279/590 (47%)