Protein Alignment Nhe3 and Nhe2

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 169/687 - (24%)
• Similarity: 282/687 - (41%)
• Gaps: 152/687 - (22%)

  Fly    26 DAKATLNHRIQSLDLLVFVFLLALT--VLTIWLFK-------HHRVSWLH----ETGLAVIYGLI 77
            :||....|:::...|....|....|  ::.||:..       .|....||    |:.|.::.|::
  Fly   171 NAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVV 235

  Fly    78 VGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQV 142
            :|.::.:.      ..:.|.|         |.|:|
  Fly   236 IGVVLYFC------TDVAVSP---------LTPNT------------------------------ 255

  Fly   143 HDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGF 207
                              ||..:|||||..|||.:..:.||.|||.||..|:|||..:...|||.
  Fly   256 ------------------FFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGS 302

  Fly   208 MYGCVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAI 272
            :|.|.|:.....|.:...:|...|.:|||..||:.:||:|.::.|:..||.:|.|||:|||||.:
  Fly   303 LYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTV 367

  Fly   273 VLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFT-RVRDFPLL 336
            |:...:::|.|  ....:.........:..||.:.|....||...|.||.|:|:|| .||   ::
  Fly   368 VMYHMMESYNE--IGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVR---VI 427

  Fly   337 ESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFI 401
            |.....:|:|..:|.||...::|::|:.||||...:|..:|:|:.|....|...::|:..||..|
  Fly   428 EPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETII 492

  Fly   402 FSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLR 466
            |.::||:... ..|.::..|::......::.|.:.|..||.|.|..|..|:|...|.::.:.|||
  Fly   493 FMFLGVATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLR 556

  Fly   467 GAMSFALA--IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIP-------------- 515
            ||::|||.  :...|..::...:|.|..::.|||.:||.....|:..|.:.
  Fly   557 GAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIH 621

  Fly   516 --------VGVDDETEQLNNYQVHSVYNSMDN-------------SHPQTSDGYLQDVEGGGVNR 559
                    .|::|...:..||.|...:...||             :.|:..:.|
  Fly   622 ERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETY----------- 675

  Fly   560 NKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYM--KPLLTHSRPT 622
            :|:.:....:.....|  .|.|.:.|...           ::.::.|:...|:  .|.||:...|
  Fly   676 SKLTMRDAMEVMRRNP--STIGQMTGTES-----------MSALFRNYTNNYIGGSPSLTNLDNT 727

  Fly   623 LLETLPVC---CNPIARLLTTTQ---QLTQDGSEFRR 653
            ....|.:.   .||..:.||..:   .|.::...:||
  Fly   728 CSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRR 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	125/400 (31%)
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	151/607 (25%)