Protein Alignment Nhe3 and Nhe1

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 204/689 - (29%)
• Similarity: 310/689 - (44%)
• Gaps: 162/689 - (23%)

  Fly    19 TDTDIALDAKATLNHRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIR 83
            ||..: :|:.|.......||.|...:.::.|.:|.|.........:|.|:.:.|..|..:|..:.
  Fly    84 TDPPL-IDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLN 147

  Fly    84 YAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDEN 148
                                                                 |..||.......
  Fly   148 -----------------------------------------------------VMSGQNGSWKRE 159

  Fly   149 EIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVK 213
            |:     |.|..||.::||||||.:||:|.|..||:|:|:||.|||.|||:||.:||..:|   .
  Fly   160 EV-----FSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY---L 216

  Fly   214 LMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAI 278
            |....::...:|.:|..||:|||..||:..:|||:.|.||..|..||.|||:||||::|||:.:|
  Fly   217 LGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASI 281

  Fly   279 QNYG--EHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALF 341
            ....  ...::|||    |...:|..|.::|..|..||.....::||:.|...:|..|.||.|:.
  Fly   282 TQSANVNAEASTGE----AMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMM 342

  Fly   342 VLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIG 406
            ::.:|:.::|||...|:|::|:|||||..:|||:.|||..::...:|....|.|:||..:|:|:|
  Fly   343 LMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLG 407

  Fly   407 VSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSF 471
            :::|:| ||..:..|:|.|.:...||||.|::||::|:|..|:.||:...|.:::|:|||||:|:
  Fly   408 LAIFSF-KHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISY 471

  Fly   472 ALAIR-NTVSDE-RQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVY 534
            ||::. |..|.| |..::|.|.:||:||.::.||:...||.:||
  Fly   472 ALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLK--------------------- 515

  Fly   535 NSMDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAI 599
                       .|..:...|.|.|..:   .||.          .|||      ||:|:......
  Fly   516 -----------PGKKRRARGSGRNAAE---EGGR----------RNGS------GRKRSKSISLS 550

  Fly   600 LARIW---------------------------GNFDTKYMKPLLTHSRPTLLETLPVCCNPIARL 637
            ..|.|                           |..|.||..|..|  |....:.|..|.:.:|
  Fly   551 KTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPFFT--RRFNSQELHECKSQMA-- 611

  Fly   638 LTTTQQLTQDGSEFRRVDS-DSDICIDNDTGNGLSQDGS 675
                 .||....:..||.. |||   ::|...||:...|
  Fly   612 -----DLTNKWYQAIRVSPLDSD---ESDEEIGLAASTS 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	150/379 (40%)
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	182/604 (30%)