Protein Alignment Nhe3 and Slc9a9

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_808577.3
• Gene: Slc9a9 / 331004
• MGIID: 2679732
• Length: 644
• Species: Mus musculus
• Alignment Length: 674
• Identity: 309/674 - (45%)
• Similarity: 405/674 - (60%)
• Gaps: 108/674 - (16%)

  Fly    37 SLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGV 101
            :::||.|.|||.||:|||||||:||..:|||||.|::||||:|.|:|||.....:....|...|.
Mouse    21 AVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGN 85

  Fly   102 PTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQV--HDVDE---NEIDLKATFDPEVF 161
            ..:|    |.||.    ||.|:        :.|.|.::.::  |::..   |.|..|.|||||:|
Mouse    86 LFFS----PSTLL----VNITD--------QVYEYKYQREINQHNISPHQGNAILEKMTFDPEIF 134

  Fly   162 FNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLM---PKYLSSSF 223
            ||::||||||:|||||||::||:|||:|||:|.:||.:|..:||..|||.||.|   .:..|..|
Mouse   135 FNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDF 199

  Fly   224 TFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNT 288
            .|.|.|:||:|:|.|||:|:||||::|.||.:||.|:.|||||||||||||:.:|..|... .|.
Mouse   200 HFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENP 263

  Fly   289 GEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAE 353
            ..|:|.||.:|:.:|..||..|..:|:|...:|||:||||::|:||:||:.||.|:|:|.||.||
Mouse   264 NAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAE 328

  Fly   354 ATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFD 418
            |..|||:|||||||:.||||||||||.||:.||||:||.:||||||.||.|:|:::|||..|.|:
Mouse   329 AAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFN 393

  Fly   419 AGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDER 483
            |.||:.||:...:.||.|:||||:|||:.||.||..|||||:.|:|||||::||||||||.|..:
Mouse   394 ALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPK 458

  Fly   484 QTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGY 548
            |.|.|.|.|:|.|||.:.||....:|.||:|.||||                 :|.|
Mouse   459 QMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVD-----------------LDES-------- 498

  Fly   549 LQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMK 613
            |::........||:      |.|:                    ...|.|.|.|:|..||.||:|
Mouse   499 LKEEPSSQQEANKL------DKNM--------------------TKTESAQLFRMWYGFDHKYLK 537

  Fly   614 PLLTHSRPTLLETLPVCCNPIARLLTTTQ----QLTQDGSEFRRVDSDSDICIDND--------- 665
            |:||||.|.|..|||..|.|::||||:.|    ||.:|..|          ||.|.
Mouse   538 PILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVE----------CIVNQDELAMNYQE 592

  Fly   666 ---------TGNGLSQDGSGAAPG 680
                     |...|.|..||..||
Mouse   593 QSPSPSSPTTKLALDQKSSGQTPG 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	214/378 (57%)
Slc9a9	NP_808577.3	Na_H_Exchanger	12..541	CDD:470090	279/587 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..644		7/27 (26%)