Protein Alignment Nhe3 and Slc9a4

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001400246.1
• Gene: Slc9a4 / 24785
• RGDID: 3721
• Length: 797
• Species: Rattus norvegicus
• Alignment Length: 574
• Identity: 144/574 - (25%)
• Similarity: 259/574 - (45%)
• Gaps: 105/574 - (18%)

  Fly    17 SATDTDIALDAKATLNHRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWL-HETGLAVIYGLIVGA 80
            |::|.|..:.. ..|::....:...|.:::|..::..|....:||:..| .|:.|.:|.|.:||:
  Rat    49 SSSDPDERISV-FELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGS 112

  Fly    81 IIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDV 145
            ||  .||                 ..|.||
  Rat   113 II--FGT-----------------HHKSPP----------------------------------- 123

  Fly   146 DENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYG 210
                     ..|..::|..:||||:..:||.:..:.||.|:|:||.:|.:|..::||.||..:|.
  Rat   124 ---------VMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYF 179

  Fly   211 CVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLS 275
            ..::....| .....|.:|.||:|||..||:.:||:|.:.||:..||.::.||::|||.:::||.
  Rat   180 ICQIKAFGL-GDINLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLY 243

  Fly   276 GAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESAL 340
            ..:..:.:.: ...:.|....|...:.|..:....:..|...|.::|.:|:||  ::...:|..:
  Rat   244 NILIAFTKMH-KFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFT--QNISAIEPLI 305

  Fly   341 FVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYI 405
            ..:.||.::|.||...|:|::|:..|.:....|...|:|:.|....|...::|:.::|..||.::
  Rat   306 VFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFM 370

  Fly   406 GVSMFTFPKHH-FDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAM 469
            |||  |..|:| ::..|:........|.||::|:.|.::.|..|....|...|.::|::|:|||.
  Rat   371 GVS--TVGKNHEWNWAFVCFTLAFCQIWRAISVFTLFYVSNQFRTFPFSIKDQLIIFYSGVRGAG 433

  Fly   470 SFALAIRNTVS--DERQTMLTATSLIVIFTVVIQGGAANFLLNWLKI------------------ 514
            ||:||....:|  ..::..:|||.::..|||..||.....|:.:|.:
  Rat   434 SFSLAFLLPLSLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHIRLM 498

  Fly   515 ---PVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRLS 565
               ..|::|...|.::|||...:...|:.       ||:.:.   :.||:.:.|
  Rat   499 DHLKAGIEDVCGQWSHYQVRDKFKKFDHR-------YLRKIL---IRRNQPKSS 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	114/399 (29%)
Slc9a4	NP_001400246.1	b_cpa1	63..621	CDD:273294	140/559 (25%)