Protein Alignment Nhe3 and Slc9a3

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_038956774.1
• Gene: Slc9a3 / 24784
• RGDID: 3720
• Length: 864
• Species: Rattus norvegicus
• Alignment Length: 600
• Identity: 150/600 - (25%)
• Similarity: 257/600 - (42%)
• Gaps: 146/600 - (24%)

  Fly    33 HRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVE 97
            |.:|...::....|:|.....::...|...|.:.|:.|.::.||::|.|:..|...|:.
  Rat    47 HHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASF------ 105

  Fly    98 PQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFF 162
                                                                     |..|.:||
  Rat   106 ---------------------------------------------------------TLTPTLFF 113

  Fly   163 NIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSS-----S 222
            ..:||||:..|||.:..:.||.|||.||.:|::||..:|...|..:||.      :||.     .
  Rat   114 FYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGV------FLSGLMGELK 172

  Fly   223 FTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSN 287
            ...||.|.||:||:..||:.:||:|.::.|:..|:.:|.|||:|||||.:||    .|..|.:..
  Rat   173 IGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVL----YNVFESFVT 233

  Fly   288 TGEFETTAF--LRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTR-VRDFPLLESALFVLMSYSTF 349
            .|....|..  ::.:..||.:.|...::|.....|.:|:|:||: ||   ::|.....::||.::
  Rat   234 LGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVR---IIEPGFVFVISYLSY 295

  Fly   350 LLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPK 414
            |.:|...|:.::|:.|||||...|...|:||.|....:...::|...||..||.::|:|......
  Rat   296 LTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVI 360

  Fly   415 HHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTV 479
            ..::..|::...:..::.||:.|...:|:||..|..::.|..|.::.:.|||||:::||.:   :
  Rat   361 WTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVV---L 422

  Fly   480 SDER----QTMLTATSLIVI-FTVVIQGGAANFLLNWLKIPVGVDDE---TEQLNNYQVHSVYNS 536
            .||:    :.:..:|:|||: |||:.||.....|:.|||:......|   .|:|:......:.::
  Rat   423 LDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSA 487

  Fly   537 MDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILA 601
            :::...|....||:|.
  Rat   488 IEDISGQIGHNYLRDK------------------------------------------------- 503

  Fly   602 RIWGNFDTKYMKPLL 616
              |.|||.|::..:|
  Rat   504 --WSNFDRKFLSKVL 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	126/391 (32%)
Slc9a3	XP_038956774.1	b_cpa1	45..644	CDD:273294	149/599 (25%)