Protein Alignment Nhe3 and Slc9a6

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_036017816.1
• Gene: Slc9a6 / 236794
• MGIID: 2443511
• Length: 732
• Species: Mus musculus
• Alignment Length: 700
• Identity: 336/700 - (48%)
• Similarity: 429/700 - (61%)
• Gaps: 82/700 - (11%)

  Fly    18 ATDTDIALDAKATLNHRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAII 82
            |.|.:|..:.:|..:||..|.:||:|:.||.||:||||||||.|..:|||||||:||||:||.::
Mouse    53 AMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVL 117

  Fly    83 RY---AGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQV-- 142
            ||   ..:....|.:..|.|..||        ||.    ||.:.        |.|.|..:|::
Mouse   118 RYGIHVPSDVNNVTLSCEVQSSPT--------TLL----VNVSG--------KFYEYTLKGEISS 162

  Fly   143 ---HDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLI 204
               ::|.:||:..|.||||||||||:|||||||||||||:::||||||:||.:|.:||.:|.|:|
Mouse   163 HELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVI 227

  Fly   205 GGFMYGCVKLM--PKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLN 267
            |..|||||.||  ...|:..|.|.|.|.|||::|.|||:|:||||::|:|||.||||:.||||||
Mouse   228 GSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLN 292

  Fly   268 DAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRD 332
            ||||||||.:|..|.....|:..|:.||..:|:..|..||..|..:|||.|.:|||:||||::|:
Mouse   293 DAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLRE 357

  Fly   333 FPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLA 397
            |.|||:.||.|||:||||||||...|||||||||||.||||||||||.:|:.||||:||||||||
Mouse   358 FQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLA 422

  Fly   398 ENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFF 462
            |||||||:|:::|||..|.|:..|::.|||...:|||.|:||||.|||:.|:.||.:|||||:.|
Mouse   423 ENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMF 487

  Fly   463 AGLRGAMSFALAIRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPV-----GVDDE- 521
            |||||||:||||||:|.:..||.|.:.|.|||.|||.:.||....:|:.|.|..     |..||
Mouse   488 AGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRYYARLWGYRDEL 552

  Fly   522 TEQLNNYQVHSVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGA 586
            |..|...:.||::...|.                                  ..||.....||..
Mouse   553 THGLYPQEAHSLFGETDR----------------------------------VGVDSDQEHLGVP 583

  Fly   587 SGGRRRNSHEKAILARIWGNFDTKYMKPLLTHSRPTLLETLPVCCNPIARLLTTTQ------QLT 645
            ...||....|.|.|.|:|.|||..|:|||||||.|.|..|||.||.||||.||:.|      ||.
Mouse   584 DNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLK 648

  Fly   646 QDGSEFRRVDSDSDICIDNDTGNGLSQDGSGAAP----GVGRRNSLSRSV 691
            .|.|:....|.|..:...:.|.|  ::..:.:||    |....::|.|.:
Mouse   649 DDDSDLILNDGDISLTYGDSTVN--TESATASAPRRFMGNSSEDALDREL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	229/383 (60%)
Slc9a6	XP_036017816.1	Na_H_Exchanger	94..>540	CDD:470090	257/465 (55%)