Protein Alignment Nhe3 and SLC9A8

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_011527038.1
• Gene: SLC9A8 / 23315
• HGNCID: 20728
• Length: 630
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 178/638 - (27%)
• Similarity: 299/638 - (46%)
• Gaps: 160/638 - (25%)

  Fly    36 QSLDLLVF--VFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEP 98
            ||..:.:|  :.:||:.::.:.|...:|:.:|.|:...|..|:::||:|:
Human    56 QSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIK--------------- 105

  Fly    99 QGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFN 163
                         .:.|:...|.                        .|.|:     |.|.:||.
Human   106 -------------IIEFKKLANW------------------------KEEEM-----FRPNMFFL 128

  Fly   164 IILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIG--------GFMYGCVKLMPKYL- 219
            ::||||||.:||||.|..||:|:|:|..||:.||.:|||::|        ||.:.||.:...::
Human   129 LLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFIL 193

  Fly   220 ----SSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQN 280
                .|.....||..||:|||..||:..:||||.|.||..|..||.|||:|||||:|||:...:.
Human   194 QADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTEEK 258

  Fly   281 YG----------------------------------EHYSNTGEFETTAFLRSLSDFFSIFLLSL 311
            |.                                  ::.|:...::|  ||::|..|..:|..|.
Human   259 YAPGSCCHLSLVIRIIPGFEEVYFINDHLQTEGLTRKNMSDVSGWQT--FLQALDYFLKMFFGSA 321

  Fly   312 MIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYN 376
            .:|...|.::||:.|...:|..|.||..:.::.:|..:.|||...|:|::|:||.||..:|||::
Human   322 ALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHH 386

  Fly   377 NLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLS 441
            |||..::...:|....:.||.|..:|:::|:|:|:|| |.|:..|:|...:....|||||::|||
Human   387 NLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEISFVIWCIVLVLFGRAVNIFPLS 450

  Fly   442 WLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVS--DERQTMLTATSLIVIFTVVIQGGA 504
            :|||..|..||:.....:::|:|||||:.:||::...:.  ::||.:.|.|.:||:||:::.||:
Human   451 YLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGS 515

  Fly   505 ANFLLNWLKIPVGVDDETEQLNNYQVH-----SVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRL 564
            ...|:..:.|.   |.:..:.|...|:     .:.|::::.|  .|:...::.|...:.|..::
Human   516 TMPLIRLMDIE---DAKAHRRNKKDVNLSKTEKMGNTVESEH--LSELTEEEYEAHYIRRQDLK- 574

  Fly   565 SGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPLLT 617
                                                ..:|  .|.||:.|..|
Human   575 ------------------------------------GFVW--LDAKYLNPFFT 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	148/424 (35%)
SLC9A8	XP_011527038.1	Na_H_Exchanger	64..591	CDD:470090	175/630 (28%)