Protein Alignment Nhe3 and nhx-4

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001024562.1
• Gene: nhx-4 / 180964
• WormBaseID: WBGene00003732
• Length: 749
• Species: Caenorhabditis elegans
• Alignment Length: 753
• Identity: 182/753 - (24%)
• Similarity: 292/753 - (38%)
• Gaps: 186/753 - (24%)

  Fly    17 SATDTDIALDAKA------------TLNHRIQSLDL--------LVFVFLLALTVLTIWLFKHHR 61
            :.::||.::||:.            ...|.:..:.:        |.||||:.|..|.     ...
 Worm    58 NTSETDESMDAEGEWVQSAPPEEIEEAKHLLDPVHVDFEHTHKPLAFVFLIILVTLA-----KPT 117

  Fly    62 VSW-----LHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQ 121
            :.|     |.|:.:.::||:::...::        ..|:::|
 Worm   118 LHWPVLRKLPESVVLMLYGVLMATAVK--------ALMRIDP----------------------- 151

  Fly   122 TNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNL 186
                              ||:              |..:||.|:||.|:..||.|::||.|...|
 Worm   152 ------------------GQL--------------DTFMFFMILLPAIVNDAGLSMQKKEFTIAL 184

  Fly   187 GAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSSSFT--FLDSLYFGALISPTDPLTILAIFND 249
            ..||.||:|||.:.|.|:...|||...:.      ||.  ||....|..|||..||:::|:.|.:
 Worm   185 PKILLFAVVGTVVHALLLAATMYGIEPIF------SFKPGFLHLFVFATLISAVDPVSVLSTFAE 243

  Fly   250 LRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFET-TAFLRS-LSDFFSIFLLSLM 312
            |.|..:|:.|:.|||:.||||.|||.....|..:....:.|..| |:.:.| :..|..:....|:
 Worm   244 LDVKKSLFILIFGESLCNDAVTIVLYRTSINVIKTSDASDEMLTITSVVGSCVVQFMIVCGFGLL 308

  Fly   313 IGAAMGCLTALMTK--FTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTY 375
            .||.:|.....:.|  .....:.|:.:    :...|..:||||....:|::|.:.|....::|..
 Worm   309 CGAVVGFAGVFIMKNMVGHQMNQPIFQ----LFCPYLAYLLAETGHYSGILASILCAAIMSYYMA 369

  Fly   376 NNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPL 440
            .|:..:.........:..:.|:|:.||.|:|||:.:: .|.||..||.....|..:.|.:....|
 Worm   370 ANMCVEMEFAAFTFSKTGSSLSESCIFFYLGVSLVSY-NHEFDFYFIAVTVFCCTLYRFLVTCTL 433

  Fly   441 SWLLNI--KRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDER----QTMLTATSLIVIF-TV 498
            |...|:  ..|.:|....|.::..||:|||:.|.|.   .:.|||    :.....|:|.:|| |.
 Worm   434 SAFYNLFASEKNRIPFTDQLVVTHAGIRGAVCFGLV---QIIDERIIPAKPYFVTTTLAMIFVTS 495

  Fly   499 VIQGGAANFLLNWLKIPVGVDDETEQ-----------LNNYQVHSVYNSMDNSHPQTSDGYLQDV 552
            ::||....|::..||||  .||.|:|           ||:..:.....| :|::..|.:.:
 Worm   496 ILQGCTIKFVMKCLKIP--GDDGTKQKDPKALRWLTHLNDKYIKKFLVS-ENTYLPTDETF---- 553

  Fly   553 EGGGVNRN-------KMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTK 610
                  ||       ...|..|..::.|....|........|.||      ..|....:||.:.:
 Worm   554 ------RNLGLPKAVSTALRIGERSHTDLQRHGEVSHTPAPSVGR------PTIAPFDFGNMEEE 606

  Fly   611 YMKPLLTHSRPTLLETLPVCCNPIARLLT-------------TTQQLTQDGSEFRRVDSDSDICI 662
            ..:...|..|           .|:||..|             |...||...|..:|...|.....
 Worm   607 NNRLPSTGRR-----------TPVARSQTRYSRHFIYAIPNETDNYLTCPVSASKRPPFDPSQVY 660

  Fly   663 DNDTGNGLSQDGSGAAPGVGRR-NSLSRS--VHLNEAN 697
            .:.  |.:|..|...|....|| ||:|.:  :.|.:.|
 Worm   661 QHQ--NTISNPGDDRARCYNRRHNSMSGADEMELKQLN 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	123/399 (31%)
nhx-4	NP_001024562.1	b_cpa1	94..637	CDD:273294	160/654 (24%)