Protein Alignment Nhe3 and nhx-9

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001023628.1
• Gene: nhx-9 / 178126
• WormBaseID: WBGene00003736
• Length: 667
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 174/718 - (24%)
• Similarity: 276/718 - (38%)
• Gaps: 209/718 - (29%)

  Fly    51 VLTIWLFKHHRV-----------SWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTY 104
            |:|:||......           .|..::.|.:|.||.:|.|:.....|.
 Worm    43 VITVWLLIASLAKILFNLMKPISKWCPDSSLLIIVGLALGWILHQTSLSG--------------- 92

  Fly   105 SDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPI 169
                                                             ||.|...||..:||||
 Worm    93 -------------------------------------------------ATLDSHTFFLYLLPPI 108

  Fly   170 IFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKY--LSSSFTFLDSLYFG 232
            ||.|||.:..:..|.|..::|.|::.||..:.|.|||.:.    ||.:|  .:.|||..:.|.|.
 Worm   109 IFDAGYFMPNRALFENFDSVLVFSVFGTIWNTFAIGGSLL----LMAQYDLFTMSFTTFEILVFS 169

  Fly   233 ALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFL 297
            ||||..||:.::|:|.::.|:..|:..|.||::.||.|.:||....:::....|     |..:.|
 Worm   170 ALISAVDPVAVIAVFEEIHVNEFLFINVFGEALFNDGVTVVLYQMFKSFALIGS-----ENLSVL 229

  Fly   298 RSLSDFFSIFLLSLMIGAAMGCLTA----LMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELT 358
            ...:...|.|:::|. |||:|.:.|    |.||:|  .|..:|......::.|..:|.||...|:
 Worm   230 DYATGGLSFFVVALG-GAAVGIIFAIAASLTTKYT--YDVRILAPVFIFVLPYMAYLTAEMVSLS 291

  Fly   359 GVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFI- 422
            .::|:..||:....|...|:::.:....|...::|...:|..||.::|:|..: .:||||..||
 Worm   292 SIIAIAICGMLMKQYIKGNVTQAAANSVKYFTKMLAQSSETVIFMFLGLSTIS-SQHHFDLYFIC 355

  Fly   423 ITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDERQTM- 486
            .|.|.| .|.||:.:....::||..|..|.....|.::.:.|||||:::.|.:....|...:.|
 Worm   356 ATLFFC-LIYRAIGIVVQCYILNRFRAKKFEMVDQFIMSYGGLRGAIAYGLVVSIPASITAKPMF 419

  Fly   487 LTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQD 551
            :|||..::.|||.:||.....|:|:|||     .:.|:.:...|.||||.           ||.
 Worm   420 ITATIAVIYFTVFLQGITIRPLVNFLKI-----KKKEERDPTMVESVYNK-----------YLD- 467

  Fly   552 VEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNS---------HEK---------- 597
                      ..:||..|      :.|..|.........|.|:         |:|
 Worm   468 ----------YMMSGVED------IAGQKGHYTFIENFERFNAKVIKPVLMRHQKRESFDASSIV 516

  Fly   598 ----------AI-LARIWGNFDTKYMKPLLTHSRPTLLETLPVCCNPIARLLTTT---------- 641
                      || ||::..|...|.::.:.:..|     ..|:..:.|:...|.|
 Worm   517 RAYEKITLEDAIKLAKVKNNIQNKRLERIKSKGR-----VAPILPDKISNQKTMTPKDLQLKRFM 576

  Fly   642 ---------------------QQLTQDGSEFRRVDSDSDICIDNDTGNGLSQDGSGAAPGVGRRN 685
                                 .::.:...:...||...||           ||...|.  ||.|:
 Worm   577 ESGENIDSLYTLFSDLLDRKLHEMNRPSVQITDVDGQDDI-----------QDDYMAE--VGSRS 628

  Fly   686 SLS 688
            :||
 Worm   629 NLS 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	122/383 (32%)
nhx-9	NP_001023628.1	Na_H_Exchanger	34..531	CDD:470090	153/598 (26%)