Protein Alignment Nhe3 and SLC9A6

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001425671.1
• Gene: SLC9A6 / 10479
• HGNCID: 11079
• Length: 731
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 344/721 - (47%)
• Similarity: 440/721 - (61%)
• Gaps: 85/721 - (11%)

  Fly     1 MLLIVG-FALCVLAPG----CSATDTDIALDAKATLNHRIQSLDLLVFVFLLALTVLTIWLFKHH 60
            :||.|| |.....:.|    ..|.|.:|..:.:|..:||..|.:||:|:.||.||:||||||||.
Human    30 LLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHR 94

  Fly    61 RVSWLHETGLAVIYGLIVGAIIRY---AGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQT 122
            |..:|||||||:||||:||.::||   ..:....|.:..|.|..||        ||.    ||.:
Human    95 RARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPT--------TLL----VNVS 147

  Fly   123 NGTKPPEGIKTYAYVFRGQV-----HDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYF 182
            .        |.|.|:.:|::     ::|.:||:..|.||||||||||:|||||||||||||:::|
Human   148 G--------KFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHF 204

  Fly   183 FRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLM--PKYLSSSFTFLDSLYFGALISPTDPLTILA 245
            |||||:||.:|.:||.:|.|:||..|||||.||  ...|:..|.|.|.|.|||::|.|||:|:||
Human   205 FRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLA 269

  Fly   246 IFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLS 310
            ||::|:|||.||||:.||||||||||||||.:|..|.....|:..|:.||..:|:..|..||..|
Human   270 IFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGS 334

  Fly   311 LMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTY 375
            ..:|||.|.:|||:||||::|:|.|||:.||.|||:||||||||...|||||||||||.||||||
Human   335 FAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTY 399

  Fly   376 NNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPL 440
            ||||.:|:.||||:|||||||||||||||:|:::|||..|.|:..|::.||:...:|||.|:|||
Human   400 NNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPL 464

  Fly   441 SWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDERQTMLTATSLIVIFTVVIQGGAA 505
            |.|||:.|:.||.:|||||:.||||||||:||||||:|.:..||.|.:.|.|||.|||.:.||..
Human   465 SLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGT 529

  Fly   506 NFLLNWLKIPV-----GVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRLS 565
            ..:|:.|.|..     |..||..       |.:|       ||.:..                |.
Human   530 TAMLSCLHIRYCARLWGYRDELR-------HGLY-------PQGTHS----------------LF 564

  Fly   566 GGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPLLTHSRPTLLETLPVC 630
            |.||.   ..||.....||.....||....|.|.|.|:|.|||..|:|||||||.|.|..|||.|
Human   565 GETDR---VGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPAC 626

  Fly   631 CNPIARLLTTTQ------QLTQDGSEFRRVDSDSDICIDNDTGNGLSQDGSGAAP----GVGRRN 685
            |.||||.||:.|      ||..|.|:....|.|..:...:.|.|  ::..:.:||    |....:
Human   627 CGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVN--TEPATSSAPRRFMGNSSED 689

  Fly   686 SLSRSV 691
            :|.|.:
Human   690 ALDREL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	226/382 (59%)
SLC9A6	NP_001425671.1	None