Protein Alignment Nhe3 and slc9a2

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_004911848.1
• Gene: slc9a2 / 101732511
• XenbaseID: XB-GENE-22069122
• Length: 791
• Species: Xenopus tropicalis
• Alignment Length: 598
• Identity: 154/598 - (25%)
• Similarity: 263/598 - (43%)
• Gaps: 145/598 - (24%)

  Fly    39 DLLVFVFLLALTVLTIWLF-KHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVP 102
            ::.:::.|.:|..:...|: |.|.:  :.|:.|.::.||::|.|:
 Frog    72 EITLWILLASLAKIGFHLYQKLHTI--VPESCLLILVGLVLGGIM-------------------- 114

  Fly   103 TYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILP 167
                          :.||:    |.|..:||                         :|||..:||
 Frog   115 --------------FGVNE----KSPPAMKT-------------------------DVFFLYLLP 136

  Fly   168 PIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSSSFTFLDSLYFG 232
            ||:..|||.|..:.||.|.|.|..:|:|||..:|..||..::|..:: ..:..::.:.|..|.||
 Frog   137 PIVLDAGYFLPTRPFFDNAGTIFWYAVVGTLWNAIGIGISLFGICQI-EAFGLTNISLLQCLLFG 200

  Fly   233 ALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFL 297
            :|||..||:.:||:|.::.|:..||.||.|||:|||||.:||....:::.|..:    .||:...
 Frog   201 SLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCEMKT----IETSDVF 261

  Fly   298 RSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVA 362
            ..::..|.:.:....||...|.:.|..|:||  |:..::|.....|.||.::|.||...|:|:||
 Frog   262 SGIAILFLVGIGGFFIGIIFGFVAAFTTRFT--RNIRVIEPLFVFLYSYLSYLTAEMFHLSGIVA 324

  Fly   363 VLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFI-ITAF 426
            :..|.:....|...|:|:.|....|...::|:.::|..||.::|||. ....|.::..|: .|.|
 Frog   325 ITTCAVSMKKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVST-VGQNHEWNWAFVCFTLF 388

  Fly   427 ICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALA--IRNTVSDERQTMLTA 489
            .| ...||..|:.|:.|:|..|...::...|.::.:.|||||:.|||.  :.::|...:...:||
 Frog   389 FC-LFWRAAGVFILTQLINFFRTIPLTMKDQFIIAYGGLRGAICFALVFLLPDSVFPRKNLFITA 452

  Fly   490 TSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQDVEG 554
            ..:::.|||.|||.....|:.:|.:...  |:.:|:.:.::||              .:|..|:.
 Frog   453 VIVVIFFTVFIQGITIRPLVEFLNVKRA--DKKQQIISEEIHS--------------RFLDHVKA 501

  Fly   555 GGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGN---------FDTK 610
            |                    |:...|.                     ||:         ||.|
 Frog   502 G--------------------VEDICGH---------------------WGHNYCKDKFKKFDEK 525

  Fly   611 YMKPLL-THSRPT 622
            :::.|| ..:.||
 Frog   526 FLRKLLIKENEPT 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	121/378 (32%)
slc9a2	XP_004911848.1	b_cpa1	63..618	CDD:273294	154/598 (26%)