Protein Alignment Nhe3 and slc9a5

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_002931737.2
• Gene: slc9a5 / 100497776
• XenbaseID: XB-GENE-484916
• Length: 887
• Species: Xenopus tropicalis
• Alignment Length: 627
• Identity: 169/627 - (26%)
• Similarity: 263/627 - (41%)
• Gaps: 138/627 - (22%)

  Fly     9 LCVL------APGCSATDTDIALDAKAT-------LNHRIQSLDLLVFVFLLALTVLTIWLFKHH 60
            ||||      ||..|.|.|:...||...       ..|.:|: ..||.|::|..::..|......
 Frog     3 LCVLLLSFLPAPLVSGTPTEYREDAAPEGFQVVRWEWHTVQA-PYLVAVWILVASLAKIVFHLSR 66

  Fly    61 RVSW-LHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNG 124
            :|:. :.|:.|.:|.||.:|.|:
 Frog    67 KVTTVVPESCLLIILGLALGGIV------------------------------------------ 89

  Fly   125 TKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAI 189
                     .|...|.|..            .:|.:||..:||||:..:||.:..:.||.|:|||
 Frog    90 ---------LAIAQRAQFQ------------LEPNMFFLFLLPPIVLDSGYFMPSRLFFDNIGAI 133

  Fly   190 LTFAIVGTTLSAFLIGGFMYG--CVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRV 252
            |.:|:|||..::|..|..::|  .|.||...:::.  .:|.|.||:|||..||:.:||:|.::.|
 Frog   134 LMYAVVGTIWNSFATGAALWGVKLVGLMDSQVNAG--LMDFLLFGSLISAVDPVAVLAVFEEVHV 196

  Fly   253 DVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAM 317
            :..|:.:|.|||:|||||.:||.....::.|  ......:...:|:.:..||.:.:....||...
 Frog   197 NETLFIIVFGESLLNDAVTVVLYKVFNSFVE--MGPENVKPMDYLKGVGSFFVVSIGGTAIGLVF 259

  Fly   318 GCLTALMTKFT-RVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSED 381
            ..|.||:|:|| |||   ::|.....|:.|...|.||...|:.::||.|||:|...|...|:|..
 Frog   260 AFLLALITRFTKRVR---IIEPLFIFLIVYLAHLTAEMVSLSSILAVTFCGLCCKKYVEANISNK 321

  Fly   382 SRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNI 446
            ||...|...:.|...:|..||.::|:|.....|..:|...:::..|.....|||.|...:.:||.
 Frog   322 SRTTVKYTMKTLASSSETIIFIFLGISAVDTSKWMWDTALVLSTLIFILTFRAVGVILQTCVLNR 386

  Fly   447 KRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSD-ERQTMLTATSLIVI-FTVVIQGGAANFLL 509
            .|...:....|.::.:.|||||::|||.|....|. :.:....||:::|: |||:.||.....|:
 Frog   387 FRLLPLDKIDQVVMSYGGLRGAVAFALVILLDGSKVKAKDYFVATTIVVVFFTVMFQGLTIKPLV 451

  Fly   510 NWLKIPVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDT 574
            .|||:. ..|.....||           :..|....|..:..||
 Frog   452 KWLKVK-RCDHHKPTLN-----------EELHEHAFDHIMAAVE--------------------- 483

  Fly   575 PVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPLL 616
            .:.|.:|         ..:..:|      |..||.||:...|
 Frog   484 DIVGHHG---------YHHWRDK------WEQFDKKYLSQWL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	127/380 (33%)
slc9a5	XP_002931737.2	Na_H_Exchanger	38..626	CDD:470090	158/592 (27%)