Protein Alignment Nhe3 and slc9a3

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_031759667.1
• Gene: slc9a3 / 100492870
• XenbaseID: XB-GENE-6468280
• Length: 814
• Species: Xenopus tropicalis
• Alignment Length: 535
• Identity: 142/535 - (26%)
• Similarity: 247/535 - (46%)
• Gaps: 95/535 - (17%)

  Fly    33 HRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVE 97
            |.:|...::....|:|.....::...|...:.:.|:.|.::.||::|.|:..|...|:.
 Frog    35 HHVQDPYIIAVWILVASLAKIVFHISHKVTTVVPESCLLIVLGLLLGGIVWAADHIASF------ 93

  Fly    98 PQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFF 162
                                                                     |..|.|||
 Frog    94 ---------------------------------------------------------TLTPTVFF 101

  Fly   163 NIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSSSFTFLD 227
            ..:||||:..|||.:..:.||.|||.||.:|::||..:|...|..:||.      ||:....:||
 Frog   102 FYLLPPIVLDAGYFMPNRLFFENLGTILLYAVIGTIWNAATTGLSLYGV------YLTGIMGYLD 160

  Fly   228 -----SLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSN 287
                 .|.||:||:..||:.:||:|.::.|:..|:.:|.|||:|||||.:||    .|..:.:..
 Frog   161 IGVLEFLLFGSLIAAVDPVAVLAVFEEVHVNDVLFIIVFGESLLNDAVTVVL----YNVFDSFVA 221

  Fly   288 TGEFETTA--FLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTR-VRDFPLLESALFVLMSYSTF 349
            .|....||  .::.:..||.:.:...:||.|...:.:|:|:||: ||   ::|.....::||.::
 Frog   222 IGGANVTAEDCVKGVVSFFVVSIGGTLIGIAFAYILSLVTRFTKHVR---IIEPGFIFIISYLSY 283

  Fly   350 LLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPK 414
            |.:|...|:.::|:.||||....|...|:||.|....:...::|...||..:|.::|:|......
 Frog   284 LTSEMLSLSAILAITFCGIFCQKYVKANISEQSATTVRYTMKMLASGAETIVFMFLGISAVNPHI 348

  Fly   415 HHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAI---R 476
            ..::..||:...:..::.|.:.|...:|:||..|..::....|.::.:.|||||::|||..   .
 Frog   349 WTWNTAFILLTLVFISVYRVIGVVLQTWILNRYRMVQLEIIDQVVMSYGGLRGAVAFALVALLDE 413

  Fly   477 NTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHS-----VYNS 536
            |.|. |:...::.|.::|.|||:.||.....|:.|||  |...:..|:..|.::||     :.::
 Frog   414 NRVK-EKNLFVSTTIIVVYFTVIFQGLTIKPLVQWLK--VKRSEHRERKLNEKLHSRAFDHICSA 475

  Fly   537 MDNSHPQTSDGYLQD 551
            :::...|....|::|
 Frog   476 IEDVSGQIGHNYIRD 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	124/386 (32%)
slc9a3	XP_031759667.1	b_cpa1	33..632	CDD:273294	142/535 (27%)