Protein Alignment Nhe3 and slc9a4

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: XP_002934548.2
• Gene: slc9a4 / 100491047
• XenbaseID: XB-GENE-485883
• Length: 755
• Species: Xenopus tropicalis
• Alignment Length: 654
• Identity: 152/654 - (23%)
• Similarity: 293/654 - (44%)
• Gaps: 113/654 - (17%)

  Fly     1 MLLIVGFALCVLAPGCSATDTDIALDAKA---------TLNHRIQSLDLLVFVFLLALTVLTIWL 56
            |||::..|:.....|...| |...:||.:         ::|:.:..:...:.::::..:...|..
 Frog     1 MLLMLLMAMASTGAGTKGT-TSSPVDASSEESARTYVFSVNYDLVQIPYEITLWIILASYAKIGF 64

  Fly    57 FKHHRV-SWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVN 120
            ..:||: ..:.|:.:.::.|||||.|| :|
 Frog    65 HLYHRLPKIMPESCILIVIGLIVGGII-FA----------------------------------- 93

  Fly   121 QTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRN 185
             |:...|| .::|                         :::|..:||||:...||.|..:.||.|
 Frog    94 -TDHKSPP-AMRT-------------------------DIYFLYLLPPIVLEGGYFLPTRPFFEN 131

  Fly   186 LGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDL 250
            :|.|:.::::||.::||.||..:||..:: ..:..:..|.|.:|.:|:|||..||:.:|.:|.::
 Frog   132 IGTIICWSVLGTLINAFGIGFSLYGICQI-EAFKLTDVTLLQNLMYGSLISAVDPVAVLTVFEEI 195

  Fly   251 RVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGA 315
            .|:..||.::.|||:|||.:.:||.....::.:.:: ....|.......:..|..:.:..::.|.
 Frog   196 SVNEQLYMIIFGESLLNDGLTVVLYNIFISFTQMHT-FESIEPADVFAGIGRFLLVGIGGVVFGI 259

  Fly   316 AMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSE 380
            ..|.|:|.:|:||  ::...:|..:..:.||.::|.|||..|:|::|:..|.:....|...|:|:
 Frog   260 IFGFLSAFITRFT--KNISSIEPLIVFMFSYLSYLSAEAFYLSGILAMTACAMTMKKYVEENISK 322

  Fly   381 DSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHH-FDAGFIITAFICAAIGRAVNVYPLSWLL 444
            :|....|...::|:.|:|..||.::|||  |..|:| ::..|:....:...|.|.::|:.|..::
 Frog   323 NSSTTIKYFMKMLSSLSETLIFVFMGVS--TVGKNHSWNWAFVSFTLLFCLIWRTLSVFLLFPII 385

  Fly   445 NIKRKPKISTNFQHMLFFAGLRGAMSFALA--IRNTVSDERQTMLTATSLIVIFTVVIQGGAANF 507
            |..|..:.:...|.::.::|||||.||:|.  :...:...::..:|:|.:::..||..:|.....
 Frog   386 NHYRTIRFTLKDQLIIAYSGLRGASSFSLVFLLPILLFPRKEMFITSTIVVIYVTVFFKGMTVGP 450

  Fly   508 LLNWLKI---------------------PVGVDDETEQLNNYQVHSVYNSMDNSHPQTSDGYLQD 551
            |:.:|.:                     ..|:.|......:||:...||.:||...:.:  .::|
 Frog   451 LVRYLNVKRTNRKETINEEIHTRLMDHLKTGIADICGIWGHYQMRQKYNQIDNKFLRRA--LIRD 513

  Fly   552 VEGGGVNRNKMRL-SGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPL 615
                  |:.|..: |......|...:..|...:|..........:.:|.:|....:.|...||.|
 Frog   514 ------NQPKSSIVSLHKKLELKQAIKMTKFGMGRDISLTSLQPYSRAYIANALSSEDVAQMKHL 572

  Fly   616 LTHS 619
            ||:|
 Frog   573 LTNS 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	106/399 (27%)
slc9a4	XP_002934548.2	b_cpa1	41..592	CDD:273294	142/613 (23%)