Protein Alignment Nhe3 and slc9a8

DIOPT Version :10

• Sequence 1: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_001184191.1
• Gene: slc9a8 / 100216016
• XenbaseID: XB-GENE-484705
• Length: 576
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 179/596 - (30%)
• Similarity: 299/596 - (50%)
• Gaps: 125/596 - (20%)

  Fly    36 QSLDLLVFVFLLAL--TVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEP 98
            ||..:.:|..||.|  .::.:.|...:|:.:|.|:...|..|:::||:|:.           :|.
 Frog    51 QSSGMSIFFSLLVLGICIILVHLLIKYRLHFLPESVAVVSLGILMGAVIKI-----------IES 104

  Fly    99 QGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFN 163
            |.:..:.                                         |.|:     |.|..||.
 Frog   105 QKLANWK-----------------------------------------EEEM-----FRPNTFFL 123

  Fly   164 IILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMY--GCVKLMPKYLSSSFTFL 226
            ::||||||.:||||.|..||:|:|:|..||:.||.:|||::||.:|  |...::.|     .|..
 Frog   124 VLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFIVGGGIYFLGQADVIYK-----LTMT 183

  Fly   227 DSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQ--NYGEHYSNTG 289
            ||..||:|||..||:..:||||.|.||..|..||.|||:|||||:|||:...:  |.| :.::..
 Frog   184 DSFAFGSLISAVDPVATIAIFNALNVDPVLNMLVFGESILNDAVSIVLTNTAEGLNRG-NMADVS 247

  Fly   290 EFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEA 354
            .::|  ||::|:.|..:|..|..:|...|.::||:.|...:|..|.||..:.::.:|..:.|:|.
 Frog   248 SWQT--FLQALAYFLKMFFGSAALGTLTGLISALVLKHLDLRKTPSLEFGMMIIFAYLPYGLSEG 310

  Fly   355 TELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDA 419
            ..|:|::|:||.||..:|||::|||..::...:|....:.|:.|..:|:::|:|:|:|| |.|:.
 Frog   311 ISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFMCETCVFAFLGLSIFSFP-HKFEI 374

  Fly   420 GFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVS--DE 482
            .|:|...:...:|||||::|||:|||..|..||:....::::|:|||||:.:||::...:.  ::
 Frog   375 SFVIWCIVLVLLGRAVNIFPLSYLLNFFRDHKITPKMMYIMWFSGLRGAIPYALSLHLELEPIEK 439

  Fly   483 RQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDD------ETEQLNNYQVHSVYNSMDNSH 541
            ||.:.|.|.:||:||::|.||....|:..    :.::|      ..:.:|..:...:.|::::.|
 Frog   440 RQLIGTTTIIIVLFTILILGGGTMPLIRL----IDIEDSKARRRSKKDVNLSKTEKMGNTIESEH 500

  Fly   542 PQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGN 606
                                  ||..|:...:            |...|:.|     :...:|
 Frog   501 ----------------------LSELTEEEYE------------AQYIRQHN-----LKGFMW-- 524

  Fly   607 FDTKYMKPLLT 617
            .|.||:.|..|
 Frog   525 LDAKYLNPFFT 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe3	NP_723202.2	Na_H_Exchanger	155..>531	CDD:470090	146/387 (38%)
slc9a8	NP_001184191.1	Na_H_Exchanger	59..>483	CDD:470090	161/493 (33%)