DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cort and CDH1

DIOPT Version :9

Sequence 1:	NP_001260144.1	Gene:	cort / 33937	FlyBaseID:	FBgn0000351	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_011512.1	Gene:	CDH1 / 852881	SGDID:	S000002971	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	607	Identity:	128/607 - (21%)
Similarity:	207/607 - (34%)	Gaps:	189/607 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVEMSVCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYV-GERFIPNRFEREN 65
            |:..:...||.|.|:..:.|..|...      ...|:..|..|:....|.| |:|:||:   |.:
Yeast     8 FMNNTPSSSPLKGSESKRVSKRPISS------SSSASLLSSPSRRSRPSTVYGDRYIPS---RTD 63

  Fly    66 IEFN----------------------LKYIGKRKERDILETGVTL-------------------- 88
            |:||                      ::|   :|||...||..||
Yeast    64 IDFNSIVSISSMASVPALNPSSTEDQVEY---QKERQAHETYNTLLKNELFGEMLSKDTVGSESS 125

  Fly    89 ------TASYWRQSGFISNINR--------------TFGIGE----------RRLFQFSSQQGTR 123
                  |....|.:....|..|              ..|:.|          |||  |:|||...
Yeast   126 IDRIKNTRPSTRGNVHAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTPRRL--FTSQQDEI 188

  Fly   124 SRVVDND-----------------SA---------DSDWPCNPRAR----------------PYA 146
            :|...|.                 ||         ||..|..|.::                ||.
Yeast   189 TRPSSNSVRGASLLTYQQRKGRRLSAASLLQSQFFDSMSPVRPDSKQLLLSPGKQFRQIAKVPYR 253

  Fly   147 IQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLW-RNLDESTMVFSVESP-TSLKYSPDG 209
            :.:|    |.:.....|:::||||..::|::.|:.:.|. .|..:...:...|:. |||.:...|
Yeast   254 VLDA----PSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAG 314

  Fly   210 KHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGYI---SCIEWSHDGKEVICGTQCGVI 271
            .|||:|..:....:.|           |..||......|:|   :|:.|::  ..:..|::...|
Yeast   315 SHLAVGQANGLVEIYD-----------VMKRKCIRTLSGHIDRVACLSWNN--HVLTSGSRDHRI 366

  Fly   272 ----IVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSI 332
                :.:..|...|   :..|...|..:|:.......||...|..:.:::...|..:|..|....
Yeast   367 LHRDVRMPDPFFET---IESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKA 428

  Fly   333 ---VFDWHPWTGEDLA----VAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELL 390
               ...|.|.....||    .|:|   .:.|:|:.....::..   |....|..:.:||.|.||:
Yeast   429 AVKAMAWSPHKRGVLATGGGTADR---RLKIWNVNTSIKMSDI---DSGSQICNMVWSKNTNELV 487

  Fly   391 V-NVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFP 454
            . :...:.:..|..|.     |::.:..|..|..| .|.|..:.|||.:.:|..|:|...|..|
Yeast   488 TSHGYSKYNLTLWDCN-----SMDPIAILKGHSFR-VLHLTLSNDGTTVVSGAGDETLRYWKLF- 545

  Fly   455 TYKREAILRKQEQKAKDKCSSL 476
                      .:.|||.:.:||
Yeast   546 ----------DKPKAKVQPNSL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_001260144.1	WD40	<166..453	CDD:225201	68/303 (22%)
		WD40	166..451	CDD:295369	67/301 (22%)
		WD40 repeat	201..244	CDD:293791	12/42 (29%)
		WD40 repeat	251..287	CDD:293791	6/39 (15%)
		WD40 repeat	292..326	CDD:293791	6/33 (18%)
		WD40 repeat	334..369	CDD:293791	8/38 (21%)
		WD40 repeat	377..419	CDD:293791	9/42 (21%)
		WD40 repeat	427..466	CDD:293791	10/38 (26%)
CDH1	NP_011512.1	WD40	269..543	CDD:421866	67/301 (22%)
		WD40 repeat	269..300	CDD:293791	8/30 (27%)
		WD40 repeat	305..342	CDD:293791	12/47 (26%)
		WD40 repeat	348..383	CDD:293791	6/39 (15%)
		WD40 repeat	388..424	CDD:293791	7/35 (20%)
		WD40 repeat	431..467	CDD:293791	8/38 (21%)
		WD40 repeat	474..512	CDD:293791	9/42 (21%)
		WD40 repeat	518..544	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810