Protein Alignment cort and CDC20

DIOPT Version :10

• Sequence 1: NP_523494.1
• Gene: cort / 33937
• FlyBaseID: FBgn0000351
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_011399.1
• Gene: CDC20 / 852762
• SGDID: S000003084
• Length: 610
• Species: Saccharomyces cerevisiae
• Alignment Length: 537
• Identity: 92/537 - (17%)
• Similarity: 180/537 - (33%)
• Gaps: 171/537 - (31%)

  Fly    14 NSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQ---------EVSYVGERFIP-------NRFE 62
            ::|.||.:.:.:..........|:.. |.||..|         :.:...:|:||       |:.:
Yeast    96 DAKKDKATFSAYSSRSYPTIGSESVV-SQTSLSQPTTSREVDEQFTVAADRYIPILQGASQNKVD 159

  Fly    63 RENIEFNLKYIGKRKERDILETGVTLTASYWRQSG---FISNINRTFGIG-ERRLFQFSSQQGTR 123
            .|.:            .:.|........|:.|...   |..|:....|:. .:|:.|:..:....
Yeast   160 PETL------------HEALPPPNASPISHLRAQTKIVFKQNVAEACGLDMNKRILQYMPEPPKC 212

  Fly   124 SRVVDNDSADSDWPCNPRARPYAIQNATH--------------------------EMPGICSPVD 162
            |.:              |.:.|.::..||                          :.||......
Yeast   213 SSL--------------RQKSYIMKKRTHYSYQQEQKIPDLIKLRKINTNPERILDAPGFQDDFY 263

  Fly   163 YNMMDWSSGGMVAMSSGQDVMLWR-NLDESTMVFSVESPT--SLKYSPDGKHLAIGCMDRNYPVL 224
            .|::.||...::|::....:.||. ...:.:::...|:.|  |:.:|.|..|::||..|.|   .
Yeast   264 LNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDFENTTICSVTWSDDDCHISIGKEDGN---T 325

  Fly   225 DLWEVRSPTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVIIVLAMPTLNTLMQLREHR 289
            ::|:|.:                  :|.|.....|..|..|         ::..|:||:
Yeast   326 EIWDVET------------------MSLIRTMRSGLGVRIG---------SLSWLDTLI------ 357

  Fly   290 HTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPA-- 352
                           |:....|:|.|.|..:|        :.||..|...|||...::.:|..
Yeast   358 ---------------ATGSRSGEIQINDVRIK--------QHIVSTWAEHTGEVCGLSYKSDGLQ 399

  Fly   353 --------SIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILV- 408
                    ::.|::  .|..:..:.::.....:|.|::...:..:|.:...:.|..:.....:.
Yeast   400 LASGGNDNTVMIWD--TRTSLPQFSKKTHTAAVKALSWCPYSPNILASGGGQTDKHIHFWNSITG 462

  Fly   409 --LASLNRVVDLMSHQDRGTLFLMWNPDGTK----------IATGG-LDDTFSLWNFFPTYKREA 460
              :.|:|....:.|        |.|....|.          :|||| .::..|::|:...:|...
Yeast   463 ARVGSINTGSQVSS--------LHWGQSHTSTNGGMMNKEIVATGGNPENAISVYNYETKFKVAE 519

  Fly   461 ILRKQEQKAKDKCSSLS 477
            ::...|  |:..||.||
Yeast   520 VVHAHE--ARICCSQLS 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_523494.1	WD40	<168..451	CDD:441893	55/309 (18%)
		WD40 repeat	201..244	CDD:293791	11/44 (25%)
		WD40 repeat	251..287	CDD:293791	8/35 (23%)
		WD40 repeat	292..326	CDD:293791	6/33 (18%)
		WD40 repeat	334..369	CDD:293791	7/44 (16%)
		WD40 repeat	377..419	CDD:293791	6/44 (14%)
		WD40 repeat	427..466	CDD:293791	10/49 (20%)
CDC20	NP_011399.1	WD40 repeat	265..301	CDD:293791	6/35 (17%)
		WD40	<280..554	CDD:441893	60/326 (18%)
		WD40 repeat	304..340	CDD:293791	12/56 (21%)
		WD40 repeat	348..381	CDD:293791	12/70 (17%)
		WD40 repeat	388..422	CDD:293791	3/35 (9%)
		WD40 repeat	430..476	CDD:293791	6/45 (13%)
		WD40 repeat	528..562	CDD:293791	4/7 (57%)